Comparing Essential Tremor with and without Soft Dystonic Signs and Tremor Combined with Dystonia : The TITAN Study
© 2024 International Parkinson and Movement Disorder Society..
BACKGROUND: Tremor disorders remain as clinical diagnoses and the rate of misdiagnosis between the commonest non-parkinsonian tremors is relatively high.
OBJECTIVES: To compare the clinical features of Essential Tremor without other features (pure ET), ET plus soft dystonic signs (ET + DS), and tremor combined with dystonia (TwD).
METHODS: We compared the clinical features of patients with pure ET, ET + DS, and TwD enrolled in The ITAlian tremor Network (TITAN). Linear regression models were performed to determine factors associated with health status and quality of life.
RESULTS: Three-hundred-eighty-three patients were included. Sex distribution was significantly different between the groups with males being more represented in pure ET and females in TwD. The initial site of tremor was different between the groups with about 40% of TwD having head tremor and ET + DS unilateral upper limb tremor at onset. This pattern mirrored the distribution of overt dystonia and soft dystonic signs at examination. Sensory trick, task-specificity, and position-dependence were more common, but not exclusive, to TwD. Pure ET patients showed the lowest degree of alcohol responsiveness and ET + DS the highest. Midline tremor was more commonly encountered and more severe in TwD than in the other groups. Regression analyses demonstrated that tremor severity, sex, age, and to a lesser degree the variable "group", independently predicted health status and quality of life, suggesting the existence of other determinants beyond tremor.
CONCLUSIONS: Pure ET and TwD manifest with a phenotypic overlap, which calls for the identification of diagnostic biomarkers. ET + DS shared features with both syndromes, suggesting intra-group heterogeneity.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
---|---|
Enthalten in: |
Movement disorders clinical practice - (2024) vom: 09. Apr. |
Sprache: |
Englisch |
---|
Links: |
---|
Themen: |
Dystonia |
---|
Anmerkungen: |
Date Revised 10.04.2024 published: Print-Electronic Citation Status Publisher |
---|
doi: |
10.1002/mdc3.14026 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM370841476 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM370841476 | ||
003 | DE-627 | ||
005 | 20240410233335.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240410s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1002/mdc3.14026 |2 doi | |
028 | 5 | 2 | |a pubmed24n1371.xml |
035 | |a (DE-627)NLM370841476 | ||
035 | |a (NLM)38594807 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Erro, Roberto |e verfasserin |4 aut | |
245 | 1 | 0 | |a Comparing Essential Tremor with and without Soft Dystonic Signs and Tremor Combined with Dystonia |b The TITAN Study |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 10.04.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status Publisher | ||
520 | |a © 2024 International Parkinson and Movement Disorder Society. | ||
520 | |a BACKGROUND: Tremor disorders remain as clinical diagnoses and the rate of misdiagnosis between the commonest non-parkinsonian tremors is relatively high | ||
520 | |a OBJECTIVES: To compare the clinical features of Essential Tremor without other features (pure ET), ET plus soft dystonic signs (ET + DS), and tremor combined with dystonia (TwD) | ||
520 | |a METHODS: We compared the clinical features of patients with pure ET, ET + DS, and TwD enrolled in The ITAlian tremor Network (TITAN). Linear regression models were performed to determine factors associated with health status and quality of life | ||
520 | |a RESULTS: Three-hundred-eighty-three patients were included. Sex distribution was significantly different between the groups with males being more represented in pure ET and females in TwD. The initial site of tremor was different between the groups with about 40% of TwD having head tremor and ET + DS unilateral upper limb tremor at onset. This pattern mirrored the distribution of overt dystonia and soft dystonic signs at examination. Sensory trick, task-specificity, and position-dependence were more common, but not exclusive, to TwD. Pure ET patients showed the lowest degree of alcohol responsiveness and ET + DS the highest. Midline tremor was more commonly encountered and more severe in TwD than in the other groups. Regression analyses demonstrated that tremor severity, sex, age, and to a lesser degree the variable "group", independently predicted health status and quality of life, suggesting the existence of other determinants beyond tremor | ||
520 | |a CONCLUSIONS: Pure ET and TwD manifest with a phenotypic overlap, which calls for the identification of diagnostic biomarkers. ET + DS shared features with both syndromes, suggesting intra-group heterogeneity | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a dystonia | |
650 | 4 | |a essential tremor plus | |
650 | 4 | |a gender | |
650 | 4 | |a quality of life | |
650 | 4 | |a soft signs | |
700 | 1 | |a Lazzeri, Giulia |e verfasserin |4 aut | |
700 | 1 | |a Terranova, Carmen |e verfasserin |4 aut | |
700 | 1 | |a Paparella, Giulia |e verfasserin |4 aut | |
700 | 1 | |a Gigante, Angelo Fabio |e verfasserin |4 aut | |
700 | 1 | |a De Micco, Rosa |e verfasserin |4 aut | |
700 | 1 | |a Magistrelli, Luca |e verfasserin |4 aut | |
700 | 1 | |a Di Biasio, Francesca |e verfasserin |4 aut | |
700 | 1 | |a Valentino, Francesca |e verfasserin |4 aut | |
700 | 1 | |a Moschella, Vincenzo |e verfasserin |4 aut | |
700 | 1 | |a Pilotto, Andrea |e verfasserin |4 aut | |
700 | 1 | |a Esposito, Marcello |e verfasserin |4 aut | |
700 | 1 | |a Olivola, Enrica |e verfasserin |4 aut | |
700 | 1 | |a Malaguti, Maria Chiara |e verfasserin |4 aut | |
700 | 1 | |a Ceravolo, Roberto |e verfasserin |4 aut | |
700 | 1 | |a Dallocchio, Carlo |e verfasserin |4 aut | |
700 | 1 | |a Spagnolo, Francesca |e verfasserin |4 aut | |
700 | 1 | |a Nicoletti, Alessandra |e verfasserin |4 aut | |
700 | 1 | |a De Rosa, Anna |e verfasserin |4 aut | |
700 | 1 | |a Di Giacopo, Raffaella |e verfasserin |4 aut | |
700 | 1 | |a Sorrentino, Cristiano |e verfasserin |4 aut | |
700 | 1 | |a Padovani, Alessandro |e verfasserin |4 aut | |
700 | 1 | |a Altavista, Maria Concetta |e verfasserin |4 aut | |
700 | 1 | |a Pacchetti, Claudio |e verfasserin |4 aut | |
700 | 1 | |a Marchese, Roberta |e verfasserin |4 aut | |
700 | 1 | |a Contaldi, Elena |e verfasserin |4 aut | |
700 | 1 | |a Tessitore, Alessandro |e verfasserin |4 aut | |
700 | 1 | |a Misceo, Salvatore |e verfasserin |4 aut | |
700 | 1 | |a Bologna, Matteo |e verfasserin |4 aut | |
700 | 1 | |a Rizzo, Vincenzo |e verfasserin |4 aut | |
700 | 1 | |a Franco, Giulia |e verfasserin |4 aut | |
700 | 1 | |a Barone, Paolo |e verfasserin |4 aut | |
700 | 0 | |a TITAN study group |e verfasserin |4 aut | |
700 | 1 | |a Angelini, Luca |e investigator |4 oth | |
700 | 1 | |a Aramini, Simone |e investigator |4 oth | |
700 | 1 | |a Bacchin, Ruggero |e investigator |4 oth | |
700 | 1 | |a Bertino, Salvatore |e investigator |4 oth | |
700 | 1 | |a Bianchi, Marta |e investigator |4 oth | |
700 | 1 | |a Castagna, Anna |e investigator |4 oth | |
700 | 1 | |a Colombatto, Federico |e investigator |4 oth | |
700 | 1 | |a Del Prete, Eleonora |e investigator |4 oth | |
700 | 1 | |a di Biase, Lazzaro |e investigator |4 oth | |
700 | 1 | |a Di Fonzo, Alessio |e investigator |4 oth | |
700 | 1 | |a Di Maggio, Giovanni |e investigator |4 oth | |
700 | 1 | |a Giglio, Augusta |e investigator |4 oth | |
700 | 1 | |a Giordano, Caterina |e investigator |4 oth | |
700 | 1 | |a Manzo, Nicoletta |e investigator |4 oth | |
700 | 1 | |a Modugno, Nicola |e investigator |4 oth | |
700 | 1 | |a Mostile, Giovanni |e investigator |4 oth | |
700 | 1 | |a Raglione, Laura Maria |e investigator |4 oth | |
700 | 1 | |a Russo, Maria |e investigator |4 oth | |
700 | 1 | |a Savorgnan, Giovanna |e investigator |4 oth | |
700 | 1 | |a Trinchillo, Assunta |e investigator |4 oth | |
700 | 1 | |a Volpe, Giampiero |e investigator |4 oth | |
700 | 1 | |a Zoccolella, Stefano |e investigator |4 oth | |
773 | 0 | 8 | |i Enthalten in |t Movement disorders clinical practice |d 2014 |g (2024) vom: 09. Apr. |w (DE-627)NLM23778761X |x 2330-1619 |7 nnns |
773 | 1 | 8 | |g year:2024 |g day:09 |g month:04 |
856 | 4 | 0 | |u http://dx.doi.org/10.1002/mdc3.14026 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |j 2024 |b 09 |c 04 |