EXPRESS : Clinical Outcomes and Clinico-Pathological Correlations in Children with MPO-ANCA-Associated Glomerulonephritis Showing Renal Arteritis
OBJECTIVE: The aim of this study was to evaluate the clinical features, pathological characteristics and prognosis in myeloperoxidase (MPO)-antineutrophil cytoplasmic antibodies-associated glomerulonephritis (AAGN) with renal arteritis.
METHODS: The study involved 97 children from five pediatric clinical centers with MPO-AAGN who exhibited distinct clinical features. The patients were divided into AAGN-A+ and AAGN-A-, based on the presence or absence of arteritis, and the disparities in clinical, histopathological characteristics, and prognosis between the two groups were evaluated.
RESULT: In contrast to the AAGN-A- group, the children in the AAGN-A+ group exhibited more pronounced clinical symptoms and renal pathological injury. Arteritis positively moderately correlated with the serum creatinine (Scr), IL-6 (interleukin-6), urinary neutrophil gelatinase-associated lipocalin (NGAL), negatively moderately correlated with serum complement C3. The renal survival rate in the AAGN-A+ group was significantly poorer than AAGN-A- group (χ2=4.278, P=0.039). Arteritis showed a good predictive value for end-stage kidney disease (ESKD), and C3 deposition and arteritis were independent risk factors for the development of ESKD in children with MPO-AAGN.
CONCLUSION: Arteritis is a significant pathological change observed in children with MPO-AAGN, and the formation of arteritis may be related to the inflammatory response and activation of the complement system.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Journal of investigative medicine : the official publication of the American Federation for Clinical Research - (2024) vom: 09. Apr., Seite 10815589241248073 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Pei [VerfasserIn] |
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| Links: |
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| Themen: |
Arteries |
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| Anmerkungen: |
Date Revised 09.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1177/10815589241248073 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370835573 |
|---|
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| 041 | |a eng | ||
| 100 | 1 | |a Zhang, Pei |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a EXPRESS |b Clinical Outcomes and Clinico-Pathological Correlations in Children with MPO-ANCA-Associated Glomerulonephritis Showing Renal Arteritis |
| 264 | 1 | |c 2024 | |
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| 500 | |a Date Revised 09.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a OBJECTIVE: The aim of this study was to evaluate the clinical features, pathological characteristics and prognosis in myeloperoxidase (MPO)-antineutrophil cytoplasmic antibodies-associated glomerulonephritis (AAGN) with renal arteritis | ||
| 520 | |a METHODS: The study involved 97 children from five pediatric clinical centers with MPO-AAGN who exhibited distinct clinical features. The patients were divided into AAGN-A+ and AAGN-A-, based on the presence or absence of arteritis, and the disparities in clinical, histopathological characteristics, and prognosis between the two groups were evaluated | ||
| 520 | |a RESULT: In contrast to the AAGN-A- group, the children in the AAGN-A+ group exhibited more pronounced clinical symptoms and renal pathological injury. Arteritis positively moderately correlated with the serum creatinine (Scr), IL-6 (interleukin-6), urinary neutrophil gelatinase-associated lipocalin (NGAL), negatively moderately correlated with serum complement C3. The renal survival rate in the AAGN-A+ group was significantly poorer than AAGN-A- group (χ2=4.278, P=0.039). Arteritis showed a good predictive value for end-stage kidney disease (ESKD), and C3 deposition and arteritis were independent risk factors for the development of ESKD in children with MPO-AAGN | ||
| 520 | |a CONCLUSION: Arteritis is a significant pathological change observed in children with MPO-AAGN, and the formation of arteritis may be related to the inflammatory response and activation of the complement system | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Arteries | |
| 650 | 4 | |a Kidney Diseases | |
| 650 | 4 | |a Kidney Failure, Chronic | |
| 700 | 1 | |a Yan, Shi-Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Hai-Peng |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Meng |e verfasserin |4 aut | |
| 700 | 1 | |a Kuang, Qian-Huining |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Kai-Li |e verfasserin |4 aut | |
| 700 | 1 | |a Fu, Meng-Zhen |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Chun-Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Zheng-Kun |e verfasserin |4 aut | |
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