Therapeutic nuclear magnetic resonance and intermittent hypoxia trigger time dependent on/off effects in circadian clocks and confirm a central role of superoxide in cellular magnetic field effects
Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved..
Cellular magnetic field effects are assumed to base on coherent singlet-triplet interconversion of radical pairs that are sensitive to applied radiofrequency (RF) and weak magnetic fields (WEMFs), known as radical pair mechanism (RPM). As a leading model, the RPM explains how quantum effects can influence biochemical and cellular signalling. Consequently, radical pairs generate reactive oxygen species (ROS) that link the RPM to redox processes, such as the response to hypoxia and the circadian clock. Therapeutic nuclear magnetic resonance (tNMR) occupies a unique position in the RPM paradigm because of the used frequencies, which are far below the range of 0.1-100 MHz postulated for the RPM to occur. Nonetheless, tNMR was shown to induce RPM like effects, such as increased extracellular H2O2 levels and altered cellular bioenergetics. In this study we compared the impact of tNMR and intermittent hypoxia on the circadian clock, as well as the role of superoxide in tNMR induced ROS partitioning. We show that both, tNMR and intermittent hypoxia, exert on/off effects on cellular clocks that are dependent on the time of application (day versus night). In addition, our data provide further evidence that superoxide plays a central role in magnetic signal transduction. tNMR used in combination with scavengers, such as Vitamin C, led to strong ROS product redistributions. This discovery might represent the first indication of radical triads in biological systems.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:72 |
|---|---|
| Enthalten in: |
Redox biology - 72(2024) vom: 05. Apr., Seite 103152 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Thoeni, Viktoria [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Circadian clock |
|---|
| Anmerkungen: |
Date Revised 25.04.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1016/j.redox.2024.103152 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM370829697 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM370829697 | ||
| 003 | DE-627 | ||
| 005 | 20240425233638.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240410s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.redox.2024.103152 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1386.xml |
| 035 | |a (DE-627)NLM370829697 | ||
| 035 | |a (NLM)38593630 | ||
| 035 | |a (PII)S2213-2317(24)00128-9 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Thoeni, Viktoria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Therapeutic nuclear magnetic resonance and intermittent hypoxia trigger time dependent on/off effects in circadian clocks and confirm a central role of superoxide in cellular magnetic field effects |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 25.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a Cellular magnetic field effects are assumed to base on coherent singlet-triplet interconversion of radical pairs that are sensitive to applied radiofrequency (RF) and weak magnetic fields (WEMFs), known as radical pair mechanism (RPM). As a leading model, the RPM explains how quantum effects can influence biochemical and cellular signalling. Consequently, radical pairs generate reactive oxygen species (ROS) that link the RPM to redox processes, such as the response to hypoxia and the circadian clock. Therapeutic nuclear magnetic resonance (tNMR) occupies a unique position in the RPM paradigm because of the used frequencies, which are far below the range of 0.1-100 MHz postulated for the RPM to occur. Nonetheless, tNMR was shown to induce RPM like effects, such as increased extracellular H2O2 levels and altered cellular bioenergetics. In this study we compared the impact of tNMR and intermittent hypoxia on the circadian clock, as well as the role of superoxide in tNMR induced ROS partitioning. We show that both, tNMR and intermittent hypoxia, exert on/off effects on cellular clocks that are dependent on the time of application (day versus night). In addition, our data provide further evidence that superoxide plays a central role in magnetic signal transduction. tNMR used in combination with scavengers, such as Vitamin C, led to strong ROS product redistributions. This discovery might represent the first indication of radical triads in biological systems | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Circadian clock | |
| 650 | 4 | |a Intermittent hypoxia | |
| 650 | 4 | |a Magnetic field effects | |
| 650 | 4 | |a Reactive oxygen species | |
| 650 | 4 | |a Superoxide | |
| 700 | 1 | |a Dimova, Elitsa Y |e verfasserin |4 aut | |
| 700 | 1 | |a Kietzmann, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Usselman, Robert J |e verfasserin |4 aut | |
| 700 | 1 | |a Egg, Margit |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Redox biology |d 2013 |g 72(2024) vom: 05. Apr., Seite 103152 |w (DE-627)NLM22743725X |x 2213-2317 |7 nnns |
| 773 | 1 | 8 | |g volume:72 |g year:2024 |g day:05 |g month:04 |g pages:103152 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.redox.2024.103152 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 72 |j 2024 |b 05 |c 04 |h 103152 | ||