Electroacupuncture can Modify Stress, Low-Grade Inflammation in the Duodenum, and Damage to the Intestinal Barrier in Rats with Functional Dyspepsia through the CRF Signaling Pathway
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: In the domain of functional gastrointestinal disorders, Functional Dyspepsia(FD) stands out due to its widespread occurrence internationally. Historically, electroacupuncture(EA) has been employed as a therapeutic modality for FD, demonstrating notableclinical efficacy.
OBJECTIVES: This research aimed to delve into the impact of EA on stress responses, minor duodenalinflammatory processes, and the integrity of the intestinal barrier within FD-affected rodentmodels while also elucidating the underlying mechanisms.
METHODS: Thirty-six male Wistar rats were evenly distributed into three cohorts: a normal, amodeled FD, and an EA treatment group. The FD condition in the rats, barring those in thenormal, was induced through a series of multifactorial procedures. For the EA cohort, the ratsreceived electroacupuncture at the acupoints RN12 (Zhongwan) and ST36 (Zusanli) for 20minutes daily over a span of one week. The gastric residue rate (GRR), intestinal propulsion rate(IPR), and changes in emotional state were measured in each group of rats. Additionally, serumlevels of corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), andcorticosterone (CORT) were detected, and the duodenal inflammatory condition and intestinalmucosal barrier status were observed through staining and fluorescence. The expression levelsof Claudin-1, Junctional Adhesion Molecule 1 (JAM-1), Corticotropin-Releasing Factor (CRF),and Corticotropin-Releasing Factor Receptor 1 (CRF-R1) were also detected.
RESULTS: The study demonstrated that EA had a positive effect on body weight and food intake,GRR, and IPR in FD rats. Additionally, the EA group showed a decrease in serum levels ofCRH, ACTH, and CORT, as well as a decrease in the number of duodenal mast cells and tryptasecontent. Furthermore, the expression of tight junction proteins Claudin-1 and JAM-1 wasincreased in the EA group compared to the model group. EA also reduced the levels of CRF andCRF-R1 in the hypothalamus and duodenum.
CONCLUSION: EA has been shown to improve the stress state of FD rats, inhibit the activation ofmast cells in the duodenum, and reduce low-grade inflammatory response and damage to the intestinalmucosal barrier. It is believed that EA achieves these effects by modulating the expressionof CRF and its receptors in the brain-gut interaction pathway through the CRF signalingpathway. This provides a new approach to treating FD.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
|---|---|
| Enthalten in: |
Combinatorial chemistry & high throughput screening - (2024) vom: 08. Apr. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Liu, Tong [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
CRF signaling pathway |
|---|
| Anmerkungen: |
Date Revised 24.04.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.2174/0113862073306526240403063736 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM370805453 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM370805453 | ||
| 003 | DE-627 | ||
| 005 | 20240424232149.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240409s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2174/0113862073306526240403063736 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1385.xml |
| 035 | |a (DE-627)NLM370805453 | ||
| 035 | |a (NLM)38591200 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Liu, Tong |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Electroacupuncture can Modify Stress, Low-Grade Inflammation in the Duodenum, and Damage to the Intestinal Barrier in Rats with Functional Dyspepsia through the CRF Signaling Pathway |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 24.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: In the domain of functional gastrointestinal disorders, Functional Dyspepsia(FD) stands out due to its widespread occurrence internationally. Historically, electroacupuncture(EA) has been employed as a therapeutic modality for FD, demonstrating notableclinical efficacy | ||
| 520 | |a OBJECTIVES: This research aimed to delve into the impact of EA on stress responses, minor duodenalinflammatory processes, and the integrity of the intestinal barrier within FD-affected rodentmodels while also elucidating the underlying mechanisms | ||
| 520 | |a METHODS: Thirty-six male Wistar rats were evenly distributed into three cohorts: a normal, amodeled FD, and an EA treatment group. The FD condition in the rats, barring those in thenormal, was induced through a series of multifactorial procedures. For the EA cohort, the ratsreceived electroacupuncture at the acupoints RN12 (Zhongwan) and ST36 (Zusanli) for 20minutes daily over a span of one week. The gastric residue rate (GRR), intestinal propulsion rate(IPR), and changes in emotional state were measured in each group of rats. Additionally, serumlevels of corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), andcorticosterone (CORT) were detected, and the duodenal inflammatory condition and intestinalmucosal barrier status were observed through staining and fluorescence. The expression levelsof Claudin-1, Junctional Adhesion Molecule 1 (JAM-1), Corticotropin-Releasing Factor (CRF),and Corticotropin-Releasing Factor Receptor 1 (CRF-R1) were also detected | ||
| 520 | |a RESULTS: The study demonstrated that EA had a positive effect on body weight and food intake,GRR, and IPR in FD rats. Additionally, the EA group showed a decrease in serum levels ofCRH, ACTH, and CORT, as well as a decrease in the number of duodenal mast cells and tryptasecontent. Furthermore, the expression of tight junction proteins Claudin-1 and JAM-1 wasincreased in the EA group compared to the model group. EA also reduced the levels of CRF andCRF-R1 in the hypothalamus and duodenum | ||
| 520 | |a CONCLUSION: EA has been shown to improve the stress state of FD rats, inhibit the activation ofmast cells in the duodenum, and reduce low-grade inflammatory response and damage to the intestinalmucosal barrier. It is believed that EA achieves these effects by modulating the expressionof CRF and its receptors in the brain-gut interaction pathway through the CRF signalingpathway. This provides a new approach to treating FD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a CRF signaling pathway | |
| 650 | 4 | |a electroacupuncture | |
| 650 | 4 | |a functional dyspepsia | |
| 650 | 4 | |a low-grade inflammation | |
| 650 | 4 | |a stress | |
| 650 | 4 | |a intestinalbarrier. | |
| 700 | 1 | |a Wang, Haili |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Jiayi |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, Ruirui |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Lili |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Xurong |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Ailin |e verfasserin |4 aut | |
| 700 | 1 | |a Qi, Chenxi |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Zhaohui |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Combinatorial chemistry & high throughput screening |d 1998 |g (2024) vom: 08. Apr. |w (DE-627)NLM097489352 |x 1875-5402 |7 nnns |
| 773 | 1 | 8 | |g year:2024 |g day:08 |g month:04 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2174/0113862073306526240403063736 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2024 |b 08 |c 04 | ||