Polymorphic markers of several immune regulatory genes modulate the susceptibility for eczema and related phenotypes in children
2024 Translational Pediatrics. All rights reserved..
Background: Eczema is associated with multiple genes regulating epidermal barrier functions and immunological pathways. However, their epistatic interactions are not well studied. This cross-sectional study investigated the relationship between childhood eczema phenotypes and single-nucleotide polymorphisms (SNPs) of immune regulatory genes.
Methods: One thousand three hundred and twenty-nine Chinese eczematous children and 1,179 non-allergic controls were recruited. Nine SNPs of immune regulatory genes signal transducer and activator of transcription 3 (STAT3), interleukin-10 (IL10), transforming growth factor-beta 1 (TGFB1), and IL-6 receptor (IL6R) were genotyped by TaqMan genotyping assays. Logistic regression was used to analyze the associations between SNPs and eczema phenotypes. Generalized multifactor dimensionality reduction (GMDR) was used to examine epistatic interactions among these SNPs as well as those reported by our group [filaggrin (FLG) and 11q13] for eczema phenotypes.
Results: TGFB1_rs1800469 was found to be associated with eczema [odds ratio (OR), 0.82; 95% confidence interval (CI): 0.73-0.92; P=0.001], atopic eczema (OR, 0.83; 95% CI: 0.72-0.95; P=0.009) and allergic rhinitis (OR, 0.84; 95% CI: 0.74-0.95; P=0.005). We also found a trend between IL10_rs1800872 and increased total immunoglobulin E (IgE) levels (P=0.009). Epistatic interaction among IL10_rs3021094, TGFB1_rs1800469, IL6R_rs2228145, and STAT3_rs4796793 were found for total IgE [testing accuracy (TA), 0.551; cross-validation consistency (CVC), 10; P=0.014]. Mean log-transformed total IgE (logIgE) levels in high-risk cases, low-risk cases, high-risk controls, and low-risk controls were 2.75, 2.60, 1.90, and 1.81 respectively (P=0.019 for trend).
Conclusions: Functional TGFB1 polymorphism is associated with both eczema and allergic rhinitis, suggesting the role of TGF-β1 in allergy susceptibility. IL10 may be associated with increased total IgE levels. Interaction among immune regulatory genes modulates total IgE levels.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Translational pediatrics - 13(2024), 3 vom: 27. März, Seite 436-446 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kung, Charmaine Jeng Sum [VerfasserIn] |
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| Links: |
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| Themen: |
Eczema |
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| Anmerkungen: |
Date Revised 10.04.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.21037/tp-23-474 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370797272 |
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| 100 | 1 | |a Kung, Charmaine Jeng Sum |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Polymorphic markers of several immune regulatory genes modulate the susceptibility for eczema and related phenotypes in children |
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| 500 | |a published: Print-Electronic | ||
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| 520 | |a 2024 Translational Pediatrics. All rights reserved. | ||
| 520 | |a Background: Eczema is associated with multiple genes regulating epidermal barrier functions and immunological pathways. However, their epistatic interactions are not well studied. This cross-sectional study investigated the relationship between childhood eczema phenotypes and single-nucleotide polymorphisms (SNPs) of immune regulatory genes | ||
| 520 | |a Methods: One thousand three hundred and twenty-nine Chinese eczematous children and 1,179 non-allergic controls were recruited. Nine SNPs of immune regulatory genes signal transducer and activator of transcription 3 (STAT3), interleukin-10 (IL10), transforming growth factor-beta 1 (TGFB1), and IL-6 receptor (IL6R) were genotyped by TaqMan genotyping assays. Logistic regression was used to analyze the associations between SNPs and eczema phenotypes. Generalized multifactor dimensionality reduction (GMDR) was used to examine epistatic interactions among these SNPs as well as those reported by our group [filaggrin (FLG) and 11q13] for eczema phenotypes | ||
| 520 | |a Results: TGFB1_rs1800469 was found to be associated with eczema [odds ratio (OR), 0.82; 95% confidence interval (CI): 0.73-0.92; P=0.001], atopic eczema (OR, 0.83; 95% CI: 0.72-0.95; P=0.009) and allergic rhinitis (OR, 0.84; 95% CI: 0.74-0.95; P=0.005). We also found a trend between IL10_rs1800872 and increased total immunoglobulin E (IgE) levels (P=0.009). Epistatic interaction among IL10_rs3021094, TGFB1_rs1800469, IL6R_rs2228145, and STAT3_rs4796793 were found for total IgE [testing accuracy (TA), 0.551; cross-validation consistency (CVC), 10; P=0.014]. Mean log-transformed total IgE (logIgE) levels in high-risk cases, low-risk cases, high-risk controls, and low-risk controls were 2.75, 2.60, 1.90, and 1.81 respectively (P=0.019 for trend) | ||
| 520 | |a Conclusions: Functional TGFB1 polymorphism is associated with both eczema and allergic rhinitis, suggesting the role of TGF-β1 in allergy susceptibility. IL10 may be associated with increased total IgE levels. Interaction among immune regulatory genes modulates total IgE levels | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Eczema | |
| 650 | 4 | |a genetics | |
| 650 | 4 | |a regulatory cytokine | |
| 650 | 4 | |a rhinitis | |
| 650 | 4 | |a transforming growth factor-beta (TGF-β) | |
| 700 | 1 | |a Hon, Kam Lun |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Man Fung |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Nam Sze |e verfasserin |4 aut | |
| 700 | 1 | |a Ng, Gigi Wing Gi |e verfasserin |4 aut | |
| 700 | 1 | |a Leung, Christy Wing Man |e verfasserin |4 aut | |
| 700 | 1 | |a Leung, Ting Fan |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:13 |g year:2024 |g number:3 |g day:27 |g month:03 |g pages:436-446 |
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