New Development in Amyloidosis Research Based on Supersaturation : Biological Factors to Induce/Inhibit the Amyloid Fibril Formation
Amyloid fibril formation is a general property of proteins and peptides. It is a physicochemical phenomenon similar to crystallization, in which amyloid precursor proteins exceeding solubility precipitate through the breakdown of supersaturation. Using the ultrasonication-forced amyloid fibril inducer HANABI, we have discovered that serum albumin acts as an inhibitor in dialysis-related amyloidosis. Exploring the factors that induce or inhibit amyloid fibril formation using HANABI can lead to the development of early diagnosis and prevention methods for amyloidosis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:76 |
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| Enthalten in: |
Brain and nerve = Shinkei kenkyu no shinpo - 76(2024), 4 vom: 08. Apr., Seite 391-397 |
| Sprache: |
Japanisch |
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| Beteiligte Personen: |
Yamaguchi, Keiichi [VerfasserIn] |
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| Links: |
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| Themen: |
Amyloid |
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| Anmerkungen: |
Date Completed 10.04.2024 Date Revised 10.04.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.11477/mf.1416202616 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370786297 |
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| 520 | |a Amyloid fibril formation is a general property of proteins and peptides. It is a physicochemical phenomenon similar to crystallization, in which amyloid precursor proteins exceeding solubility precipitate through the breakdown of supersaturation. Using the ultrasonication-forced amyloid fibril inducer HANABI, we have discovered that serum albumin acts as an inhibitor in dialysis-related amyloidosis. Exploring the factors that induce or inhibit amyloid fibril formation using HANABI can lead to the development of early diagnosis and prevention methods for amyloidosis | ||
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