Osteoporotic fracture risk in women with breast cancer treated with aromatase inhibitors : a health insurance claims database study in Japan
BACKGROUND: Hormone therapy with aromatase inhibitors (AIs) for estrogen receptor-dependent breast cancer may expose patients to an increased osteoporosis risk. This study was performed to estimate fracture risk in women with breast cancer to whom AIs were prescribed in Japan.
METHODS: This retrospective study used data from the Japanese Medical Data Vision database. Women with breast cancer prescribed AIs over a 12-month period were identified and matched to women not prescribed AIs using a propensity score. Fracture rates were estimated by a cumulative incidence function and compared using a cause-specific Cox hazard model. The proportion of women undergoing bone density tests was retrieved.
RESULTS: For all fractures sites combined, cumulative fracture incidence at 10 years was 0.19 [95%CI: 0.16-0.22] in women prescribed AIs and 0.18 [95%CI: 0.15-0.21] without AIs. AI prescription was not associated with any changes in risk (adjusted hazard ratio: 1.08 [95%CI: 0.99-1.17] p = 0.08). Women prescribed AI more frequently underwent bone density testing (31.9% [95% CI: 31.2%; 32.6%] versus 2.2% [95% CI: 2.0%; 2.4%]).
CONCLUSIONS: The anticipated association between AI exposure and osteoporotic fracture risk in Japanese women with breast cancer was not seen clearly.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Expert opinion on pharmacotherapy - 25(2024), 3 vom: 08. Feb., Seite 325-334 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Taguchi, Tetsuya [VerfasserIn] |
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| Links: |
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| Themen: |
Antineoplastic Agents, Hormonal |
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| Anmerkungen: |
Date Completed 25.04.2024 Date Revised 25.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/14656566.2024.2340712 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370778928 |
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| 500 | |a Date Revised 25.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Hormone therapy with aromatase inhibitors (AIs) for estrogen receptor-dependent breast cancer may expose patients to an increased osteoporosis risk. This study was performed to estimate fracture risk in women with breast cancer to whom AIs were prescribed in Japan | ||
| 520 | |a METHODS: This retrospective study used data from the Japanese Medical Data Vision database. Women with breast cancer prescribed AIs over a 12-month period were identified and matched to women not prescribed AIs using a propensity score. Fracture rates were estimated by a cumulative incidence function and compared using a cause-specific Cox hazard model. The proportion of women undergoing bone density tests was retrieved | ||
| 520 | |a RESULTS: For all fractures sites combined, cumulative fracture incidence at 10 years was 0.19 [95%CI: 0.16-0.22] in women prescribed AIs and 0.18 [95%CI: 0.15-0.21] without AIs. AI prescription was not associated with any changes in risk (adjusted hazard ratio: 1.08 [95%CI: 0.99-1.17] p = 0.08). Women prescribed AI more frequently underwent bone density testing (31.9% [95% CI: 31.2%; 32.6%] versus 2.2% [95% CI: 2.0%; 2.4%]) | ||
| 520 | |a CONCLUSIONS: The anticipated association between AI exposure and osteoporotic fracture risk in Japanese women with breast cancer was not seen clearly | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Aromatase inhibitors | |
| 650 | 4 | |a Japan | |
| 650 | 4 | |a breast cancer | |
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a fracture risk | |
| 650 | 4 | |a osteoporosis | |
| 650 | 7 | |a Aromatase Inhibitors |2 NLM | |
| 650 | 7 | |a Antineoplastic Agents, Hormonal |2 NLM | |
| 700 | 1 | |a Matsushima, Hisashi |e verfasserin |4 aut | |
| 700 | 1 | |a Kodama, Sho |e verfasserin |4 aut | |
| 700 | 1 | |a Okubo, Naoki |e verfasserin |4 aut | |
| 700 | 1 | |a Ito, Tetsuo |e verfasserin |4 aut | |
| 700 | 1 | |a Ludwikowska, Maja |e verfasserin |4 aut | |
| 700 | 1 | |a Fukumoto, Seiji |e verfasserin |4 aut | |
| 700 | 1 | |a Matsumoto, Toshio |e verfasserin |4 aut | |
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