Extended blood stage sensitivity profiles of Plasmodium cynomolgi to doxycycline and tafenoquine, as a model for Plasmodium vivax
Testing Plasmodium vivax antimicrobial sensitivity is limited to ex vivo schizont maturation assays, which preclude determining the IC50s of delayed action antimalarials such as doxycycline. Using Plasmodium cynomolgi as a model for P. vivax, we determined the physiologically significant delayed death effect induced by doxycycline [IC50(96 h), 1,401 ± 607 nM]. As expected, IC50(96 h) to chloroquine (20.4 nM), piperaquine (12.6 µM), and tafenoquine (1,424 nM) were not affected by extended exposure.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Antimicrobial agents and chemotherapy - (2024) vom: 08. Apr., Seite e0028024 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Christensen, Peter [VerfasserIn] |
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| Links: |
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| Themen: |
Antimalarial agents |
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| Anmerkungen: |
Date Revised 08.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1128/aac.00280-24 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370768094 |
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| 245 | 1 | 0 | |a Extended blood stage sensitivity profiles of Plasmodium cynomolgi to doxycycline and tafenoquine, as a model for Plasmodium vivax |
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| 520 | |a Testing Plasmodium vivax antimicrobial sensitivity is limited to ex vivo schizont maturation assays, which preclude determining the IC50s of delayed action antimalarials such as doxycycline. Using Plasmodium cynomolgi as a model for P. vivax, we determined the physiologically significant delayed death effect induced by doxycycline [IC50(96 h), 1,401 ± 607 nM]. As expected, IC50(96 h) to chloroquine (20.4 nM), piperaquine (12.6 µM), and tafenoquine (1,424 nM) were not affected by extended exposure | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Plasmodium cynomolgi | |
| 650 | 4 | |a Plasmodium vivax | |
| 650 | 4 | |a antimalarial agents | |
| 650 | 4 | |a chloroquine | |
| 650 | 4 | |a doxycycline | |
| 650 | 4 | |a tafenoquine | |
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| 700 | 1 | |a Suwanarusk, Rossarin |e verfasserin |4 aut | |
| 700 | 1 | |a Chua, Adeline Chiew Yen |e verfasserin |4 aut | |
| 700 | 1 | |a Kaneko, Osamu |e verfasserin |4 aut | |
| 700 | 1 | |a Kyle, Dennis E |e verfasserin |4 aut | |
| 700 | 1 | |a Aung, Htin Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Matheson, Jessica |e verfasserin |4 aut | |
| 700 | 1 | |a Bifani, Pablo |e verfasserin |4 aut | |
| 700 | 1 | |a Rénia, Laurent |e verfasserin |4 aut | |
| 700 | 1 | |a Cook, Gregory M |e verfasserin |4 aut | |
| 700 | 1 | |a Snounou, Georges |e verfasserin |4 aut | |
| 700 | 1 | |a Russell, Bruce |e verfasserin |4 aut | |
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