Melatonin receptor structure and signaling
© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd..
Melatonin (5-methoxy-N-acetyltryptamine) binds with high affinity and specificity to membrane receptors. Several receptor subtypes exist in different species, of which the mammalian MT1 and MT2 receptors are the best-characterized. They are members of the G protein-coupled receptor superfamily, preferentially coupling to Gi/o proteins but also to other G proteins in a cell-context-depending manner. In this review, experts on melatonin receptors will summarize the current state of the field. We briefly report on the discovery and classification of melatonin receptors, then focus on the molecular structure of human MT1 and MT2 receptors and highlight the importance of molecular simulations to identify new ligands and to understand the structural dynamics of these receptors. We then describe the state-of-the-art of the intracellular signaling pathways activated by melatonin receptors and their complexes. Brief statements on the molecular toolbox available for melatonin receptor studies and future perspectives will round-up this review.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:76 |
|---|---|
| Enthalten in: |
Journal of pineal research - 76(2024), 3 vom: 14. Apr., Seite e12952 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Okamoto, Hiroyuki H [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 09.04.2024 Date Revised 09.04.2024 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1111/jpi.12952 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM370766520 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM370766520 | ||
| 003 | DE-627 | ||
| 005 | 20240409233046.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240408s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/jpi.12952 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1370.xml |
| 035 | |a (DE-627)NLM370766520 | ||
| 035 | |a (NLM)38587234 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Okamoto, Hiroyuki H |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Melatonin receptor structure and signaling |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 09.04.2024 | ||
| 500 | |a Date Revised 09.04.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. | ||
| 520 | |a Melatonin (5-methoxy-N-acetyltryptamine) binds with high affinity and specificity to membrane receptors. Several receptor subtypes exist in different species, of which the mammalian MT1 and MT2 receptors are the best-characterized. They are members of the G protein-coupled receptor superfamily, preferentially coupling to Gi/o proteins but also to other G proteins in a cell-context-depending manner. In this review, experts on melatonin receptors will summarize the current state of the field. We briefly report on the discovery and classification of melatonin receptors, then focus on the molecular structure of human MT1 and MT2 receptors and highlight the importance of molecular simulations to identify new ligands and to understand the structural dynamics of these receptors. We then describe the state-of-the-art of the intracellular signaling pathways activated by melatonin receptors and their complexes. Brief statements on the molecular toolbox available for melatonin receptor studies and future perspectives will round-up this review | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a G protein‐coupled receptors | |
| 650 | 4 | |a MT1 | |
| 650 | 4 | |a MT2 | |
| 650 | 4 | |a crystal structure | |
| 650 | 4 | |a melatonin | |
| 650 | 4 | |a melatonin receptors | |
| 650 | 4 | |a molecular modeling | |
| 650 | 4 | |a signaling | |
| 650 | 7 | |a Receptors, Melatonin |2 NLM | |
| 650 | 7 | |a Receptor, Melatonin, MT1 |2 NLM | |
| 650 | 7 | |a Receptor, Melatonin, MT2 |2 NLM | |
| 650 | 7 | |a Melatonin |2 NLM | |
| 650 | 7 | |a JL5DK93RCL |2 NLM | |
| 650 | 7 | |a Receptors, G-Protein-Coupled |2 NLM | |
| 700 | 1 | |a Cecon, Erika |e verfasserin |4 aut | |
| 700 | 1 | |a Nureki, Osamu |e verfasserin |4 aut | |
| 700 | 1 | |a Rivara, Silvia |e verfasserin |4 aut | |
| 700 | 1 | |a Jockers, Ralf |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of pineal research |d 1993 |g 76(2024), 3 vom: 14. Apr., Seite e12952 |w (DE-627)NLM012679038 |x 1600-079X |7 nnns |
| 773 | 1 | 8 | |g volume:76 |g year:2024 |g number:3 |g day:14 |g month:04 |g pages:e12952 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1111/jpi.12952 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 76 |j 2024 |e 3 |b 14 |c 04 |h e12952 | ||