Phyto-fabrication of Moringa oleifera peel-sourced silver nanoparticles : A promising approach for combating hepatic cancer by targeting proinflammatory cytokines and mitigating cytokine storms
© 2024 Wiley‐VCH GmbH..
Hepatocellular carcinoma (HCC) arises from precancerous nodules, leading to liver damage and inflammation, which triggers the release of proinflammatory cytokines. Dysregulation of these cytokines can escalate into a cytokine storm, causing severe organ damage. Interestingly, Moringa oleifera (M. oleifera) fruit peel, previously discarded as waste, contains an abundance of essential biomolecules and high nutritional value. This study focuses on the eco-friendly synthesis of silver nanoparticles infused with M. oleifera peel extract biomolecules and their impact on regulating proinflammatory cytokines, as well as their potential anticancer effects against Wistar rats. The freshly synthesized nanoformulation underwent comprehensive characterization, followed by antihepatic cancer evaluation using a diethyl nitrosamine-induced model (at a dose of 200 mg kg-1 BW). The study demonstrates a significant reduction in proinflammatory cytokines such as tumor necrosis factor-α, interleukin-6, interleukin-1β, and nuclear factor kappa beta (NF-kB). Furthermore, it confirms that the newly biosynthesized silver nanoparticles exhibit additional potential against hepatic cancer due to their capped biomolecules.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Chemistry & biodiversity - (2024) vom: 07. Apr., Seite e202400059 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sameem, Shahnawaz [VerfasserIn] |
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| Links: |
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| Themen: |
Hepatic carcinoma |
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| Anmerkungen: |
Date Revised 07.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1002/cbdv.202400059 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Hepatocellular carcinoma (HCC) arises from precancerous nodules, leading to liver damage and inflammation, which triggers the release of proinflammatory cytokines. Dysregulation of these cytokines can escalate into a cytokine storm, causing severe organ damage. Interestingly, Moringa oleifera (M. oleifera) fruit peel, previously discarded as waste, contains an abundance of essential biomolecules and high nutritional value. This study focuses on the eco-friendly synthesis of silver nanoparticles infused with M. oleifera peel extract biomolecules and their impact on regulating proinflammatory cytokines, as well as their potential anticancer effects against Wistar rats. The freshly synthesized nanoformulation underwent comprehensive characterization, followed by antihepatic cancer evaluation using a diethyl nitrosamine-induced model (at a dose of 200 mg kg-1 BW). The study demonstrates a significant reduction in proinflammatory cytokines such as tumor necrosis factor-α, interleukin-6, interleukin-1β, and nuclear factor kappa beta (NF-kB). Furthermore, it confirms that the newly biosynthesized silver nanoparticles exhibit additional potential against hepatic cancer due to their capped biomolecules | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Hepatic carcinoma | |
| 650 | 4 | |a Moringa oleifera | |
| 650 | 4 | |a Phytofabrication | |
| 650 | 4 | |a Silver nanoparticles | |
| 700 | 1 | |a Dwivedi, Vivek |e verfasserin |4 aut | |
| 700 | 1 | |a Kumar, Vikas |e verfasserin |4 aut | |
| 700 | 1 | |a Dwivedi, Ashish R |e verfasserin |4 aut | |
| 700 | 1 | |a Pathak, Prateek |e verfasserin |4 aut | |
| 700 | 1 | |a Singh, Bhupendra |e verfasserin |4 aut | |
| 700 | 1 | |a Bhat, Mashooq Ahmad |e verfasserin |4 aut | |
| 700 | 1 | |a Verma, Amita |e verfasserin |4 aut | |
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