FERONIA-mediated TIR1/AFB2 oxidation stimulates auxin signalling in Arabidopsis
Copyright © 2024 The Author. Published by Elsevier Inc. All rights reserved..
The phytohormone auxin plays a pivotal role in governing plant growth and development. While the TRANSPORT INHIBITOR RESPONSE1/AUXIN SIGNALING F-BOX (TIR1/AFBs) receptors function in both the nucleus and cytoplasm, the mechanism governing the distribution of TIR1/AFBs between these small cellular compartments remains unknown. In this study, we demonstrate that auxin-mediated oxidation of TIR1/AFB2 is essential for their targeting to the nucleus. Our findings reveal that small active molecules, reactive oxygen species (ROS) and nitric oxide (NO), are indispensable for the nucleo-cytoplasmic distribution of TIR1/AFB2 in trichoblasts and root hairs. This process is regulated by the FERONIA receptor kinase-NADPH oxidase signaling pathway. ROS and NO initiate oxidative modifications in TIR1C140/516 and AFB2C135/511, facilitating their subsequent nuclear import. The oxidized forms of TIR1C140/516 and AFB2C135/511 play a crucial role in enhancing the functionality of TIR1 and AFB2 in transcriptional auxin responses. In summary, our study unveils a novel mechanism through which auxin stimulates the transportation of TIR1/AFB2 from the cytoplasm to the nucleus, orchestrated by the FERONIA-ROS signaling pathway.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Molecular plant - (2024) vom: 04. Apr. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lu, Baiyan [VerfasserIn] |
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| Links: |
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| Themen: |
FERONIA |
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| Anmerkungen: |
Date Revised 06.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.molp.2024.04.002 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370705335 |
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| 520 | |a Copyright © 2024 The Author. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a The phytohormone auxin plays a pivotal role in governing plant growth and development. While the TRANSPORT INHIBITOR RESPONSE1/AUXIN SIGNALING F-BOX (TIR1/AFBs) receptors function in both the nucleus and cytoplasm, the mechanism governing the distribution of TIR1/AFBs between these small cellular compartments remains unknown. In this study, we demonstrate that auxin-mediated oxidation of TIR1/AFB2 is essential for their targeting to the nucleus. Our findings reveal that small active molecules, reactive oxygen species (ROS) and nitric oxide (NO), are indispensable for the nucleo-cytoplasmic distribution of TIR1/AFB2 in trichoblasts and root hairs. This process is regulated by the FERONIA receptor kinase-NADPH oxidase signaling pathway. ROS and NO initiate oxidative modifications in TIR1C140/516 and AFB2C135/511, facilitating their subsequent nuclear import. The oxidized forms of TIR1C140/516 and AFB2C135/511 play a crucial role in enhancing the functionality of TIR1 and AFB2 in transcriptional auxin responses. In summary, our study unveils a novel mechanism through which auxin stimulates the transportation of TIR1/AFB2 from the cytoplasm to the nucleus, orchestrated by the FERONIA-ROS signaling pathway | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a FERONIA | |
| 650 | 4 | |a TIR1/AFBs | |
| 650 | 4 | |a nucleo-cytoplasmic distribution | |
| 650 | 4 | |a oxidative modification | |
| 650 | 4 | |a root hair development | |
| 700 | 1 | |a Wang, Shengnan |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Hanqian |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Kaixing |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yilin |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Minmin |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Yanshu |e verfasserin |4 aut | |
| 700 | 1 | |a Peng, Chao |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Chao |e verfasserin |4 aut | |
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