The epidemiology of fungal infections in transplant patients
Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved..
Transplant patients, including solid-organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients, are exposed to various types of complications, particularly rejection. To prevent these outcomes, transplant recipients commonly receive long-term immunosuppressive regimens that in turn make them more susceptible to a wide array of infectious diseases, notably those caused by opportunistic pathogens. Among these, invasive fungal infections (IFIs) remain a major cause of mortality and morbidity in both SOT and HSCT recipients. Despite the continuing improvement in early diagnostics and treatments of IFIs, the management of these infections in transplant patients is still complicated. Here, we provide an overview concerning the most recent trends in the epidemiology of IFIs in SOT and HSCT recipients by describing the prominent yeasts and molds species involved, the timing of post-transplant IFIs and the risk factors associated with their occurrence in these particularly weak populations. We also give special emphasis into basic research advances in the field that recently suggested a role of the global and long-term prophylactic regimen in orchestrating various biological disturbances in the organism and conditioning the emergence of the most adapted fungal strains to the particular physiological profiles of transplant patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Biomedical journal - (2024) vom: 03. Apr., Seite 100719 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mahmoud, Dorra Elhaj [VerfasserIn] |
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| Anmerkungen: |
Date Revised 05.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.bj.2024.100719 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370694643 |
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| 520 | |a Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a Transplant patients, including solid-organ transplant (SOT) and hematopoietic stem cell transplant (HSCT) recipients, are exposed to various types of complications, particularly rejection. To prevent these outcomes, transplant recipients commonly receive long-term immunosuppressive regimens that in turn make them more susceptible to a wide array of infectious diseases, notably those caused by opportunistic pathogens. Among these, invasive fungal infections (IFIs) remain a major cause of mortality and morbidity in both SOT and HSCT recipients. Despite the continuing improvement in early diagnostics and treatments of IFIs, the management of these infections in transplant patients is still complicated. Here, we provide an overview concerning the most recent trends in the epidemiology of IFIs in SOT and HSCT recipients by describing the prominent yeasts and molds species involved, the timing of post-transplant IFIs and the risk factors associated with their occurrence in these particularly weak populations. We also give special emphasis into basic research advances in the field that recently suggested a role of the global and long-term prophylactic regimen in orchestrating various biological disturbances in the organism and conditioning the emergence of the most adapted fungal strains to the particular physiological profiles of transplant patients | ||
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| 700 | 1 | |a Morio, Florent |e verfasserin |4 aut | |
| 700 | 1 | |a Briard, Benoit |e verfasserin |4 aut | |
| 700 | 1 | |a Vigneau, Cécile |e verfasserin |4 aut | |
| 700 | 1 | |a Desoubeaux, Guillaume |e verfasserin |4 aut | |
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| 700 | 1 | |a Gal, Soléne LE |e verfasserin |4 aut | |
| 700 | 1 | |a Papon, Nicolas |e verfasserin |4 aut | |
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