Details der Publikation - COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19

COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19 : a USIDNET Report

© 2024. The Author(s)..

BACKGROUND: The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI.

OBJECTIVE: To estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI.

METHODS: We built a secure registry database in conjunction with the US Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients. The registry opened on January 1, 2022, and closed on August 19, 2022.

RESULTS: Physicians entered data on 1245 patients from 24 countries. The most common diagnoses were antibody deficiencies (63.7%). At least one COVID-19 vaccine was administered to 806 patients (64.7%), and 216 patients received vaccination prior to the development of COVID-19. The most common vaccines administered were mRNA-based (84.0%). Seventeen patients were reported to seek outpatient clinic or emergency room care for a vaccine-related complication, and one patient was hospitalized for symptomatic anemia. Eight hundred twenty-three patients (66.1%) experienced COVID-19 infection. Of these, 156 patients required hospitalization (19.0%), 47 required ICU care (5.7%), and 28 died (3.4%). Rates of hospitalization (9.3% versus 24.4%, p < 0.001), ICU admission (2.8% versus 7.6%, p = 0.013), and death (2.3% versus 4.3%, p = 0.202) in patients who had COVID-19 were lower in patients who received vaccination prior to infection. In adjusted logistic regression analysis, not having at least one COVID-19 vaccine significantly increased the odds of hospitalization and ICU admission.

CONCLUSION: Vaccination for COVID-19 in the IEI population appears safe and attenuates COVID-19 severity.

Errataetall:	UpdateOf: Res Sq. 2023 Aug 19;:. - PMID 37645807
Medienart:	E-Artikel

Erscheinungsjahr:	2024
Erschienen:	2024

Enthalten in:	Zur Gesamtaufnahme - volume:44
Enthalten in:	Journal of clinical immunology - 44(2024), 4 vom: 05. Apr., Seite 86

Sprache:	Englisch

Beteiligte Personen:	McDonnell, John [VerfasserIn] Cousins, Kimberley [VerfasserIn] Younger, M Elizabeth M [VerfasserIn] Lane, Adam [VerfasserIn] Abolhassani, Hassan [VerfasserIn] Abraham, Roshini S [VerfasserIn] Al-Tamemi, Salem [VerfasserIn] Aldave-Becerra, Juan Carlos [VerfasserIn] Al-Faris, Eman Hesham [VerfasserIn] Alfaro-Murillo, Alberto [VerfasserIn] AlKhater, Suzan A [VerfasserIn] Alsaati, Nouf [VerfasserIn] Doss, Alexa Michelle Altman [VerfasserIn] Anderson, Melissa [VerfasserIn] Angarola, Ernestina [VerfasserIn] Ariue, Barbara [VerfasserIn] Arnold, Danielle E [VerfasserIn] Assa'ad, Amal H [VerfasserIn] Aytekin, Caner [VerfasserIn] Bank, Meaghan [VerfasserIn] Bergerson, Jenna R E [VerfasserIn] Bleesing, Jack [VerfasserIn] Boesing, John [VerfasserIn] Bouso, Carolina [VerfasserIn] Brodszki, Nicholas [VerfasserIn] Cabanillas, Diana [VerfasserIn] Cady, Carol [VerfasserIn] Callahan, Meghan A [VerfasserIn] Caorsi, Roberta [VerfasserIn] Carbone, Javier [VerfasserIn] Carrabba, Maria [VerfasserIn] Castagnoli, Riccardo [VerfasserIn] Catanzaro, Jason R [VerfasserIn] Chan, Samantha [VerfasserIn] Chandra, Sharat [VerfasserIn] Chapdelaine, Hugo [VerfasserIn] Chavoshzadeh, Zahra [VerfasserIn] Chong, Hey Jin [VerfasserIn] Connors, Lori [VerfasserIn] Consonni, Filippo [VerfasserIn] Correa-Jimenez, Oscar [VerfasserIn] Cunningham-Rundles, Charlotte [VerfasserIn] D'Astous-Gauthier, Katherine [VerfasserIn] Delmonte, Ottavia Maria [VerfasserIn] Demirdag, Yesim Yilmaz [VerfasserIn] Deshpande, Deepti R [VerfasserIn] Diaz-Cabrera, Natalie M [VerfasserIn] Dimitriades, Victoria R [VerfasserIn] El-Owaidy, Rasha [VerfasserIn] ElGhazali, Gehad [VerfasserIn] Al-Hammadi, Suleiman [VerfasserIn] Fabio, Giovanna [VerfasserIn] Faure, Astrid Schellnast [VerfasserIn] Feng, Jin [VerfasserIn] Fernandez, James M [VerfasserIn] Fill, Lauren [VerfasserIn] Franco, Guacira R [VerfasserIn] Frenck, Robert W [VerfasserIn] Fuleihan, Ramsay L [VerfasserIn] Giardino, Giuliana [VerfasserIn] Galant-Swafford, Jessica [VerfasserIn] Gambineri, Eleonora [VerfasserIn] Garabedian, Elizabeth K [VerfasserIn] Geerlinks, Ashley V [VerfasserIn] Goudouris, Ekaterini [VerfasserIn] Grecco, Octavio [VerfasserIn] Pan-Hammarström, Qiang [VerfasserIn] Khani, Hedieh Haji Khodaverdi [VerfasserIn] Hammarström, Lennart [VerfasserIn] Hartog, Nicholas L [VerfasserIn] Heimall, Jennifer [VerfasserIn] Hernandez-Molina, Gabriela [VerfasserIn] Horner, Caroline C [VerfasserIn] Hostoffer, Robert W [VerfasserIn] Hristova, Nataliya [VerfasserIn] Hsiao, Kuang-Chih [VerfasserIn] Ivankovich-Escoto, Gabriela [VerfasserIn] Jaber, Faris [VerfasserIn] Jalil, Maaz [VerfasserIn] Jamee, Mahnaz [VerfasserIn] Jean, Tiffany [VerfasserIn] Jeong, Stephanie [VerfasserIn] Jhaveri, Devi [VerfasserIn] Jordan, Michael B [VerfasserIn] Joshi, Avni Y [VerfasserIn] Kalkat, Amanpreet [VerfasserIn] Kanarek, Henry J [VerfasserIn] Kellner, Erinn S [VerfasserIn] Khojah, Amer [VerfasserIn] Khoury, Ruby [VerfasserIn] Kokron, Cristina M [VerfasserIn] Kumar, Ashish [VerfasserIn] Lecerf, Kelsey [VerfasserIn] Lehman, Heather K [VerfasserIn] Leiding, Jennifer W [VerfasserIn] Lesmana, Harry [VerfasserIn] Lim, Xin Rong [VerfasserIn] Lopes, Joao Pedro [VerfasserIn] López, Ana Laura [VerfasserIn] Tarquini, Lucia [VerfasserIn] et al [Sonstige Person]

Links:	Volltext

Themen:	COVID-19 Vaccines Immunization Immunodeficiency Journal Article Outcomes Viruses: respiratory diseases

Anmerkungen:	Date Completed 08.04.2024 Date Revised 15.04.2024 published: Electronic UpdateOf: Res Sq. 2023 Aug 19;:. - PMID 37645807 Citation Status MEDLINE

doi:	10.1007/s10875-023-01613-5

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	NLM370678036

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500			\|a UpdateOf: Res Sq. 2023 Aug 19;:. - PMID 37645807
500			\|a Citation Status MEDLINE
520			\|a © 2024. The Author(s).
520			\|a BACKGROUND: The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and whether vaccination attenuates infection severity in IEI
520			\|a OBJECTIVE: To estimate COVID-19 vaccination safety and examine effect on outcomes in patients with IEI
520			\|a METHODS: We built a secure registry database in conjunction with the US Immunodeficiency Network to examine vaccination frequency and indicators of safety and effectiveness in IEI patients. The registry opened on January 1, 2022, and closed on August 19, 2022
520			\|a RESULTS: Physicians entered data on 1245 patients from 24 countries. The most common diagnoses were antibody deficiencies (63.7%). At least one COVID-19 vaccine was administered to 806 patients (64.7%), and 216 patients received vaccination prior to the development of COVID-19. The most common vaccines administered were mRNA-based (84.0%). Seventeen patients were reported to seek outpatient clinic or emergency room care for a vaccine-related complication, and one patient was hospitalized for symptomatic anemia. Eight hundred twenty-three patients (66.1%) experienced COVID-19 infection. Of these, 156 patients required hospitalization (19.0%), 47 required ICU care (5.7%), and 28 died (3.4%). Rates of hospitalization (9.3% versus 24.4%, p < 0.001), ICU admission (2.8% versus 7.6%, p = 0.013), and death (2.3% versus 4.3%, p = 0.202) in patients who had COVID-19 were lower in patients who received vaccination prior to infection. In adjusted logistic regression analysis, not having at least one COVID-19 vaccine significantly increased the odds of hospitalization and ICU admission
520			\|a CONCLUSION: Vaccination for COVID-19 in the IEI population appears safe and attenuates COVID-19 severity
650		4	\|a Journal Article
650		4	\|a Immunization
650		4	\|a Immunodeficiency
650		4	\|a Outcomes
650		4	\|a Viruses: respiratory diseases
650		7	\|a COVID-19 Vaccines \|2 NLM
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700	1		\|a AlKhater, Suzan A \|e verfasserin \|4 aut
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700	1		\|a Doss, Alexa Michelle Altman \|e verfasserin \|4 aut
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700	1		\|a Angarola, Ernestina \|e verfasserin \|4 aut
700	1		\|a Ariue, Barbara \|e verfasserin \|4 aut
700	1		\|a Arnold, Danielle E \|e verfasserin \|4 aut
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700	1		\|a Bank, Meaghan \|e verfasserin \|4 aut
700	1		\|a Bergerson, Jenna R E \|e verfasserin \|4 aut
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700	1		\|a Cabanillas, Diana \|e verfasserin \|4 aut
700	1		\|a Cady, Carol \|e verfasserin \|4 aut
700	1		\|a Callahan, Meghan A \|e verfasserin \|4 aut
700	1		\|a Caorsi, Roberta \|e verfasserin \|4 aut
700	1		\|a Carbone, Javier \|e verfasserin \|4 aut
700	1		\|a Carrabba, Maria \|e verfasserin \|4 aut
700	1		\|a Castagnoli, Riccardo \|e verfasserin \|4 aut
700	1		\|a Catanzaro, Jason R \|e verfasserin \|4 aut
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700	1		\|a Chandra, Sharat \|e verfasserin \|4 aut
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700	1		\|a Chavoshzadeh, Zahra \|e verfasserin \|4 aut
700	1		\|a Chong, Hey Jin \|e verfasserin \|4 aut
700	1		\|a Connors, Lori \|e verfasserin \|4 aut
700	1		\|a Consonni, Filippo \|e verfasserin \|4 aut
700	1		\|a Correa-Jimenez, Oscar \|e verfasserin \|4 aut
700	1		\|a Cunningham-Rundles, Charlotte \|e verfasserin \|4 aut
700	1		\|a D'Astous-Gauthier, Katherine \|e verfasserin \|4 aut
700	1		\|a Delmonte, Ottavia Maria \|e verfasserin \|4 aut
700	1		\|a Demirdag, Yesim Yilmaz \|e verfasserin \|4 aut
700	1		\|a Deshpande, Deepti R \|e verfasserin \|4 aut
700	1		\|a Diaz-Cabrera, Natalie M \|e verfasserin \|4 aut
700	1		\|a Dimitriades, Victoria R \|e verfasserin \|4 aut
700	1		\|a El-Owaidy, Rasha \|e verfasserin \|4 aut
700	1		\|a ElGhazali, Gehad \|e verfasserin \|4 aut
700	1		\|a Al-Hammadi, Suleiman \|e verfasserin \|4 aut
700	1		\|a Fabio, Giovanna \|e verfasserin \|4 aut
700	1		\|a Faure, Astrid Schellnast \|e verfasserin \|4 aut
700	1		\|a Feng, Jin \|e verfasserin \|4 aut
700	1		\|a Fernandez, James M \|e verfasserin \|4 aut
700	1		\|a Fill, Lauren \|e verfasserin \|4 aut
700	1		\|a Franco, Guacira R \|e verfasserin \|4 aut
700	1		\|a Frenck, Robert W \|e verfasserin \|4 aut
700	1		\|a Fuleihan, Ramsay L \|e verfasserin \|4 aut
700	1		\|a Giardino, Giuliana \|e verfasserin \|4 aut
700	1		\|a Galant-Swafford, Jessica \|e verfasserin \|4 aut
700	1		\|a Gambineri, Eleonora \|e verfasserin \|4 aut
700	1		\|a Garabedian, Elizabeth K \|e verfasserin \|4 aut
700	1		\|a Geerlinks, Ashley V \|e verfasserin \|4 aut
700	1		\|a Goudouris, Ekaterini \|e verfasserin \|4 aut
700	1		\|a Grecco, Octavio \|e verfasserin \|4 aut
700	1		\|a Pan-Hammarström, Qiang \|e verfasserin \|4 aut
700	1		\|a Khani, Hedieh Haji Khodaverdi \|e verfasserin \|4 aut
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700	1		\|a Hartog, Nicholas L \|e verfasserin \|4 aut
700	1		\|a Heimall, Jennifer \|e verfasserin \|4 aut
700	1		\|a Hernandez-Molina, Gabriela \|e verfasserin \|4 aut
700	1		\|a Horner, Caroline C \|e verfasserin \|4 aut
700	1		\|a Hostoffer, Robert W \|e verfasserin \|4 aut
700	1		\|a Hristova, Nataliya \|e verfasserin \|4 aut
700	1		\|a Hsiao, Kuang-Chih \|e verfasserin \|4 aut
700	1		\|a Ivankovich-Escoto, Gabriela \|e verfasserin \|4 aut
700	1		\|a Jaber, Faris \|e verfasserin \|4 aut
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700	1		\|a Joshi, Avni Y \|e verfasserin \|4 aut
700	1		\|a Kalkat, Amanpreet \|e verfasserin \|4 aut
700	1		\|a Kanarek, Henry J \|e verfasserin \|4 aut
700	1		\|a Kellner, Erinn S \|e verfasserin \|4 aut
700	1		\|a Khojah, Amer \|e verfasserin \|4 aut
700	1		\|a Khoury, Ruby \|e verfasserin \|4 aut
700	1		\|a Kokron, Cristina M \|e verfasserin \|4 aut
700	1		\|a Kumar, Ashish \|e verfasserin \|4 aut
700	1		\|a Lecerf, Kelsey \|e verfasserin \|4 aut
700	1		\|a Lehman, Heather K \|e verfasserin \|4 aut
700	1		\|a Leiding, Jennifer W \|e verfasserin \|4 aut
700	1		\|a Lesmana, Harry \|e verfasserin \|4 aut
700	1		\|a Lim, Xin Rong \|e verfasserin \|4 aut
700	1		\|a Lopes, Joao Pedro \|e verfasserin \|4 aut
700	1		\|a López, Ana Laura \|e verfasserin \|4 aut
700	1		\|a Tarquini, Lucia \|e verfasserin \|4 aut
700	0		\|a et al \|4 oth
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COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19 : a USIDNET Report

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