Multimorbidity of Allergic Diseases Is Associated With Functional Gastrointestinal Disorders in a Young Japanese Population
Background/Aims: Although certain allergic diseases have been reported to be associated with the prevalence of functional dyspepsia (FD) and irritable bowel syndrome (IBS), it is unclear whether the presence of multiple allergic diseases further increases the prevalence of FD and IBS. The aim of this study is to determine this issue in young people.
Methods: A cohort of 8923 Japanese university students was enrolled and diagnoses of FD and IBS were confirmed using Rome III criteria. Allergic disorders diagnosed at medical institutions were obtained by means of a self-administered questionnaire.
Results: The prevalence of FD, IBS, and their overlap was found to be 1.9%, 6.5%, and 1.1%, respectively. Pollen allergy was independently positively correlated with FD, IBS, and overlap of FD and IBS. Allergic rhinitis was positively linked to IBS. Drug allergy was positively associated with FD. The presence of multiple allergic diseases was positively correlated with FD and IBS (FD: adjusted OR for 2 allergic diseases: 1.95 [95% CI, 1.24-2.98], P for trend = 0.003; and IBS: adjusted OR for 1 allergic disease: 1.40 [95% CI, 1.15-1.69], 2 allergic diseases 1.47 [95% CI, 1.12-1.91], and 3 or more allergic diseases: 2.22 [95% CI, 1.45-3.28], P for trend = 0.001). Additionally, the concomitant existence of multiple allergic diseases was also demonstrated to have a trend that correlated with the overlap of FD and IBS (P for trend = 0.018).
Conclusion: Allergic disease multimorbidity is positively correlated with the prevalence of FD and IBS in a young population.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Journal of neurogastroenterology and motility - 30(2024), 2 vom: 30. Apr., Seite 229-235 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yamamoto, Yasunori [VerfasserIn] |
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| Links: |
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| Themen: |
Allergy |
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| Anmerkungen: |
Date Revised 10.04.2024 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.5056/jnm23015 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370657934 |
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| 100 | 1 | |a Yamamoto, Yasunori |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Multimorbidity of Allergic Diseases Is Associated With Functional Gastrointestinal Disorders in a Young Japanese Population |
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| 500 | |a Date Revised 10.04.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Background/Aims: Although certain allergic diseases have been reported to be associated with the prevalence of functional dyspepsia (FD) and irritable bowel syndrome (IBS), it is unclear whether the presence of multiple allergic diseases further increases the prevalence of FD and IBS. The aim of this study is to determine this issue in young people | ||
| 520 | |a Methods: A cohort of 8923 Japanese university students was enrolled and diagnoses of FD and IBS were confirmed using Rome III criteria. Allergic disorders diagnosed at medical institutions were obtained by means of a self-administered questionnaire | ||
| 520 | |a Results: The prevalence of FD, IBS, and their overlap was found to be 1.9%, 6.5%, and 1.1%, respectively. Pollen allergy was independently positively correlated with FD, IBS, and overlap of FD and IBS. Allergic rhinitis was positively linked to IBS. Drug allergy was positively associated with FD. The presence of multiple allergic diseases was positively correlated with FD and IBS (FD: adjusted OR for 2 allergic diseases: 1.95 [95% CI, 1.24-2.98], P for trend = 0.003; and IBS: adjusted OR for 1 allergic disease: 1.40 [95% CI, 1.15-1.69], 2 allergic diseases 1.47 [95% CI, 1.12-1.91], and 3 or more allergic diseases: 2.22 [95% CI, 1.45-3.28], P for trend = 0.001). Additionally, the concomitant existence of multiple allergic diseases was also demonstrated to have a trend that correlated with the overlap of FD and IBS (P for trend = 0.018) | ||
| 520 | |a Conclusion: Allergic disease multimorbidity is positively correlated with the prevalence of FD and IBS in a young population | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Allergy | |
| 650 | 4 | |a Gastrointestinal diseases | |
| 650 | 4 | |a Irritable bowel syndrome | |
| 700 | 1 | |a Furukawa, Shinya |e verfasserin |4 aut | |
| 700 | 1 | |a Miyake, Teruki |e verfasserin |4 aut | |
| 700 | 1 | |a Watanabe, Junichi |e verfasserin |4 aut | |
| 700 | 1 | |a Nakamura, Yukihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Taguchi, Yoshihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Yamamoto, Tetsuya |e verfasserin |4 aut | |
| 700 | 1 | |a Kato, Aki |e verfasserin |4 aut | |
| 700 | 1 | |a Kusumoto, Katsunori |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshida, Osamu |e verfasserin |4 aut | |
| 700 | 1 | |a Takeshita, Eiji |e verfasserin |4 aut | |
| 700 | 1 | |a Ikeda, Yoshio |e verfasserin |4 aut | |
| 700 | 1 | |a Yamamoto, Naofumi |e verfasserin |4 aut | |
| 700 | 1 | |a Saeki, Yuka |e verfasserin |4 aut | |
| 700 | 1 | |a Yamaguchi, Osamu |e verfasserin |4 aut | |
| 700 | 1 | |a Hiasa, Yoichi |e verfasserin |4 aut | |
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