Relapsing bronchopneumonia due to community-associated methicillin-resistant Staphylococcus aureus : a case report
© 2024. The Author(s)..
BACKGROUND: The emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has increased the incidence of community-onset MRSA infection. Respiratory tract infections caused by MRSA has been noted for their severity; however, repeated relapses that require extended antibiotic therapy are rare.
CASE PRESENTATION: We report a case of relapsing bronchopneumonia caused by CA-MRSA in a 56-year-old man. The patient responded to antibiotics, but repeatedly relapsed after stopping treatment. MRSA was consistently isolated from airway specimens during each relapse. Extended oral antibiotic treatment with trimethoprim/sulfamethoxazole (TMP/SMX) for 6 months achieved infection control. Whole-genome sequencing of the isolated strain revealed that the causative agent was sequence type (ST)1/staphylococcal cassette chromosome mec (SCCmec) type IVa, a clone that is rapidly increasing in Japan.
DISCUSSION AND CONCLUSIONS: This patient had an unusual course of MRSA bronchopneumonia with repeated relapses. Although the choice of antibiotics for long-term use in MRSA respiratory tract infections has not been well established, TMP/SMX was effective and well tolerated for long-term therapy in this case. The clinical course of infections related to the rapid emerging clone, ST1/SCCmec type IVa warrants further attention.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
BMC infectious diseases - 24(2024), 1 vom: 04. Apr., Seite 374 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shimada, Sho [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 08.04.2024 Date Revised 08.04.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12879-024-09268-2 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370653246 |
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| 520 | |a © 2024. The Author(s). | ||
| 520 | |a BACKGROUND: The emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has increased the incidence of community-onset MRSA infection. Respiratory tract infections caused by MRSA has been noted for their severity; however, repeated relapses that require extended antibiotic therapy are rare | ||
| 520 | |a CASE PRESENTATION: We report a case of relapsing bronchopneumonia caused by CA-MRSA in a 56-year-old man. The patient responded to antibiotics, but repeatedly relapsed after stopping treatment. MRSA was consistently isolated from airway specimens during each relapse. Extended oral antibiotic treatment with trimethoprim/sulfamethoxazole (TMP/SMX) for 6 months achieved infection control. Whole-genome sequencing of the isolated strain revealed that the causative agent was sequence type (ST)1/staphylococcal cassette chromosome mec (SCCmec) type IVa, a clone that is rapidly increasing in Japan | ||
| 520 | |a DISCUSSION AND CONCLUSIONS: This patient had an unusual course of MRSA bronchopneumonia with repeated relapses. Although the choice of antibiotics for long-term use in MRSA respiratory tract infections has not been well established, TMP/SMX was effective and well tolerated for long-term therapy in this case. The clinical course of infections related to the rapid emerging clone, ST1/SCCmec type IVa warrants further attention | ||
| 650 | 4 | |a Case Reports | |
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| 700 | 1 | |a Mitsumura, Takahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Komori, Kohji |e verfasserin |4 aut | |
| 700 | 1 | |a Yamana, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Iijima, Yuki |e verfasserin |4 aut | |
| 700 | 1 | |a Sakakibara, Rie |e verfasserin |4 aut | |
| 700 | 1 | |a Shibata, Sho |e verfasserin |4 aut | |
| 700 | 1 | |a Honda, Takayuki |e verfasserin |4 aut | |
| 700 | 1 | |a Shirai, Tsuyoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Okamoto, Tsukasa |e verfasserin |4 aut | |
| 700 | 1 | |a Furusawa, Haruhiko |e verfasserin |4 aut | |
| 700 | 1 | |a Tateishi, Tomoya |e verfasserin |4 aut | |
| 700 | 1 | |a Miyazaki, Yasunari |e verfasserin |4 aut | |
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