X-Ray-Triggered CO-Release from Gold Nanocluster : All-in-One Nanoplatforms for Cancer Targeted Gas and Radio Synergistic Therapy
© 2024 Wiley‐VCH GmbH..
Glycolysis-dominant metabolic pathway in cancer cells can promote their therapeutic resistance against radiotherapy (RT). Carbon monoxide (CO) as a glycolysis inhibitor can enhance the efficiency of RT. Herein, an X-ray responsive CO-releasing nanocomposite (HAAuNC@CO) based on strong host-guest interactions between the radiosensitizer and CO donor for enhanced RT is developed. The encapsulated gold nanoclusters (CD-AuNCs) can effectively generate cytotoxic reactive oxygen species (ROS) under X-ray radiation, which not only directly inactivate cancer cells but also induce in situ CO gas generation from adamantane modified metal carbonyl (Ada-CO) for glycolysis inhibition. Both in vitro and in vivo results demonstrate that HA@AuNC@CO exhibits active targeting toward CD44 overexpressed cancer cells, along with excellent inhibition of glycolysis and efficient RT against cancer. This study offers a new strategy for the combination of gas therapy and RT in tumor treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Advanced materials (Deerfield Beach, Fla.) - (2024) vom: 04. Apr., Seite e2401017 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cao, Lei [VerfasserIn] |
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| Links: |
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| Themen: |
CO gas therapy |
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| Anmerkungen: |
Date Revised 10.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1002/adma.202401017 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370632087 |
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| 520 | |a Glycolysis-dominant metabolic pathway in cancer cells can promote their therapeutic resistance against radiotherapy (RT). Carbon monoxide (CO) as a glycolysis inhibitor can enhance the efficiency of RT. Herein, an X-ray responsive CO-releasing nanocomposite (HAAuNC@CO) based on strong host-guest interactions between the radiosensitizer and CO donor for enhanced RT is developed. The encapsulated gold nanoclusters (CD-AuNCs) can effectively generate cytotoxic reactive oxygen species (ROS) under X-ray radiation, which not only directly inactivate cancer cells but also induce in situ CO gas generation from adamantane modified metal carbonyl (Ada-CO) for glycolysis inhibition. Both in vitro and in vivo results demonstrate that HA@AuNC@CO exhibits active targeting toward CD44 overexpressed cancer cells, along with excellent inhibition of glycolysis and efficient RT against cancer. This study offers a new strategy for the combination of gas therapy and RT in tumor treatment | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a glycolysis inhibition | |
| 650 | 4 | |a gold nanocluster | |
| 650 | 4 | |a pancreatic cancer treatment | |
| 650 | 4 | |a radiotherapy | |
| 700 | 1 | |a Yang, Yating |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Yanlin |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Minghong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Tongtong |e verfasserin |4 aut | |
| 700 | 1 | |a Mu, Chuan |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Min |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Bin |e verfasserin |4 aut | |
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