Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19
INTRODUCTION: Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT.
PATIENTS AND METHODS: This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison. Outcome analyses were adjusted for age and sex.
RESULTS: We included 70 patients with COVID-CVT from 23 hospitals in 15 countries and 206 controls from 14 hospitals in 13 countries. The proportion of women was smaller in the COVID-CVT group (50% vs 68%, p < 0.01). A higher proportion of COVID-CVT patients presented with altered mental state (44% vs 25%, p < 0.01), the median thrombus load was higher in COVID-CVT patients (3 [IQR 2-4] vs 2 [1-3], p < 0.01) and the length of hospital stay was longer compared to controls (11 days [IQR 7-20] vs 8 [4-15], p = 0.02). In-hospital mortality did not differ (5/67 [7%, 95% CI 3-16] vs 7/206 [3%, 2-7], aOR 2.6 [95% CI 0.7-9]), nor did the frequency of functional independence after 6 months (modified Rankin Scale 0-2; 45/58 [78%, 95% CI 65-86] vs 161/185 [87%, 81-91], aOR 0.5 [95% CI 0.2-1.02]).
CONCLUSION: In contrast to previous studies, the in-hospital mortality rate and functional outcomes during follow-up did not differ between COVID-CVT patients and the pre-COVID-19 controls.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
European stroke journal - (2024) vom: 04. Apr., Seite 23969873241241885 |
| Sprache: |
Englisch |
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Date Revised 04.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1177/23969873241241885 |
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| PPN (Katalog-ID): |
NLM370622227 |
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| 100 | 1 | |a Scutelnic, Adrian |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19 |
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| 500 | |a Date Revised 04.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a INTRODUCTION: Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT | ||
| 520 | |a PATIENTS AND METHODS: This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison. Outcome analyses were adjusted for age and sex | ||
| 520 | |a RESULTS: We included 70 patients with COVID-CVT from 23 hospitals in 15 countries and 206 controls from 14 hospitals in 13 countries. The proportion of women was smaller in the COVID-CVT group (50% vs 68%, p < 0.01). A higher proportion of COVID-CVT patients presented with altered mental state (44% vs 25%, p < 0.01), the median thrombus load was higher in COVID-CVT patients (3 [IQR 2-4] vs 2 [1-3], p < 0.01) and the length of hospital stay was longer compared to controls (11 days [IQR 7-20] vs 8 [4-15], p = 0.02). In-hospital mortality did not differ (5/67 [7%, 95% CI 3-16] vs 7/206 [3%, 2-7], aOR 2.6 [95% CI 0.7-9]), nor did the frequency of functional independence after 6 months (modified Rankin Scale 0-2; 45/58 [78%, 95% CI 65-86] vs 161/185 [87%, 81-91], aOR 0.5 [95% CI 0.2-1.02]) | ||
| 520 | |a CONCLUSION: In contrast to previous studies, the in-hospital mortality rate and functional outcomes during follow-up did not differ between COVID-CVT patients and the pre-COVID-19 controls | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Cerebral venous thrombosis | |
| 650 | 4 | |a stroke | |
| 700 | 1 | |a van de Munckhof, Anita |e verfasserin |4 aut | |
| 700 | 1 | |a Miraclin, Angel T |e verfasserin |4 aut | |
| 700 | 1 | |a Aaron, Sanjith |e verfasserin |4 aut | |
| 700 | 1 | |a Hameed, Sajid |e verfasserin |4 aut | |
| 700 | 1 | |a Wasay, Mohammad |e verfasserin |4 aut | |
| 700 | 1 | |a Grosu, Oxana |e verfasserin |4 aut | |
| 700 | 1 | |a Krzywicka, Katarzyna |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez van Kammen, Mayte |e verfasserin |4 aut | |
| 700 | 1 | |a Lindgren, Erik |e verfasserin |4 aut | |
| 700 | 1 | |a Moreira, Tiago |e verfasserin |4 aut | |
| 700 | 1 | |a Acampora, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Negro, Alberto |e verfasserin |4 aut | |
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