Ultra-processed food consumption and mortality among patients with stages I-III colorectal cancer : a prospective cohort study
© 2024 The Author(s)..
Background: Ultra-processed foods (UPFs) are emerging as a risk factor for colorectal cancer (CRC), yet how post-diagnostic UPF intake may impact CRC prognosis remains unexplored.
Methods: Data collected from food frequency questionnaires were used to estimate intakes of total UPFs and UPF subgroups (serving/d) at least 6 months but less than 4 years post-diagnosis among 2498 patients diagnosed with stages I-III CRC within the Nurses' Health Study and Health Professionals Follow-up Study during 1980-2016. Hazard ratios (HR) and 95% confidence intervals (CIs) of all-cause, CRC- and cardiovascular disease (CVD)-specific mortality in association with UPF consumption were estimated using an inverse probability weighted multivariable Cox proportional hazards regression model, adjusted for confounders.
Findings: The mean (SD) age of patients at diagnosis was 68.5 (9.4) years. A total of 1661 deaths were documented, including 321 from CRC and 335 from CVD. Compared to those in the lowest quintile (median = 3.6 servings/d), patients in the highest quintile (median = 10 servings/d) of post-diagnostic UPF intake had higher CVD mortality (HR = 1.65, 95% CI = 1.13-2.40) but not CRC or all-cause mortality. Among UPF subgroups, higher consumption of fats/condiments/sauces was associated with a higher risk of CVD-specific mortality (highest vs. lowest quintile of intake, HR = 1.96, 95% CI = 1.41-2.73), and higher intake of ice cream/sherbet was associated with an increased risk of CRC-specific mortality (highest vs. lowest quintile, HR = 1.86, 95% CI: 1.33-2.61). No statistically significant association was found between UPF subgroups and overall mortality.
Interpretation: Higher post-diagnostic intake of total UPFs and fats/condiments/sauces in CRC survivors is associated with higher CVD mortality, and higher ice cream/sherbet intake is linked to higher CRC mortality.
Funding: US National Institutes of Health and the American Cancer Society.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:71 |
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| Enthalten in: |
EClinicalMedicine - 71(2024) vom: 13. Apr., Seite 102572 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hang, Dong [VerfasserIn] |
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| Links: |
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| Themen: |
Colorectal cancer survivorship |
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| Anmerkungen: |
Date Revised 05.04.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.eclinm.2024.102572 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370615018 |
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| 245 | 1 | 0 | |a Ultra-processed food consumption and mortality among patients with stages I-III colorectal cancer |b a prospective cohort study |
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| 500 | |a Date Revised 05.04.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2024 The Author(s). | ||
| 520 | |a Background: Ultra-processed foods (UPFs) are emerging as a risk factor for colorectal cancer (CRC), yet how post-diagnostic UPF intake may impact CRC prognosis remains unexplored | ||
| 520 | |a Methods: Data collected from food frequency questionnaires were used to estimate intakes of total UPFs and UPF subgroups (serving/d) at least 6 months but less than 4 years post-diagnosis among 2498 patients diagnosed with stages I-III CRC within the Nurses' Health Study and Health Professionals Follow-up Study during 1980-2016. Hazard ratios (HR) and 95% confidence intervals (CIs) of all-cause, CRC- and cardiovascular disease (CVD)-specific mortality in association with UPF consumption were estimated using an inverse probability weighted multivariable Cox proportional hazards regression model, adjusted for confounders | ||
| 520 | |a Findings: The mean (SD) age of patients at diagnosis was 68.5 (9.4) years. A total of 1661 deaths were documented, including 321 from CRC and 335 from CVD. Compared to those in the lowest quintile (median = 3.6 servings/d), patients in the highest quintile (median = 10 servings/d) of post-diagnostic UPF intake had higher CVD mortality (HR = 1.65, 95% CI = 1.13-2.40) but not CRC or all-cause mortality. Among UPF subgroups, higher consumption of fats/condiments/sauces was associated with a higher risk of CVD-specific mortality (highest vs. lowest quintile of intake, HR = 1.96, 95% CI = 1.41-2.73), and higher intake of ice cream/sherbet was associated with an increased risk of CRC-specific mortality (highest vs. lowest quintile, HR = 1.86, 95% CI: 1.33-2.61). No statistically significant association was found between UPF subgroups and overall mortality | ||
| 520 | |a Interpretation: Higher post-diagnostic intake of total UPFs and fats/condiments/sauces in CRC survivors is associated with higher CVD mortality, and higher ice cream/sherbet intake is linked to higher CRC mortality | ||
| 520 | |a Funding: US National Institutes of Health and the American Cancer Society | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Colorectal cancer survivorship | |
| 650 | 4 | |a Longitudinal analysis | |
| 650 | 4 | |a Patient care | |
| 650 | 4 | |a Post-diagnostic dietary intake | |
| 700 | 1 | |a Du, Mengxi |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Lu |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Kai |e verfasserin |4 aut | |
| 700 | 1 | |a Fang, Zhe |e verfasserin |4 aut | |
| 700 | 1 | |a Khandpur, Neha |e verfasserin |4 aut | |
| 700 | 1 | |a Rossato, Sinara Laurini |e verfasserin |4 aut | |
| 700 | 1 | |a Steele, Eurídice Martínez |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, Andrew T |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Frank B |e verfasserin |4 aut | |
| 700 | 1 | |a Meyerhardt, Jeffrey A |e verfasserin |4 aut | |
| 700 | 1 | |a Mozaffarian, Dariush |e verfasserin |4 aut | |
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| 700 | 1 | |a Sun, Qi |e verfasserin |4 aut | |
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| 700 | 1 | |a Zhang, Fang Fang |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Mingyang |e verfasserin |4 aut | |
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