Association between hyperuricemia and ultrasound-detected hand synovitis
This article is protected by copyright. All rights reserved..
OBJECTIVE: Although hand synovitis is prevalent in the older population, the aetiology remains unclear. Hyperuricemia, a modifiable metabolic disorder, may serve as an underlying mechanism of hand synovitis, but little is known about their relationship. We assessed the association between hyperuricemia and hand synovitis in a large population-based sample.
METHODS: We performed a cross-sectional study in Longshan County, Hunan Province, China. Hyperuricemia was defined as a serum urate >420 μmol/L in men and >360 μmol/L in women. Ultrasound examinations were performed on both hands of 4,080 participants, and both grey-scale synovitis and Power Doppler signal (PDS) were assessed using semiquantitative scores (grades 0-3). We evaluated the association of hyperuricemia with hand grey-scale synovitis (grade ≥2) and PDS (grade ≥1), respectively, adjusting for age, sex and body mass index.
RESULTS: All required assessments for analysis were available on 3,286 participants. The prevalence of hand grey-scale synovitis was higher among participants with hyperuricemia (30.0%) than those with normouricemia (23.3%), with an adjusted odds ratio (aOR) of 1.28 (95% confidence interval [CI]:1.00-1.62). Participants with hyperuricemia also had higher prevalence of PDS (aOR=2.36, 95% CI:1.15-4.81). Furthermore, hyperuricemia positively associated, both at the hand and joint levels, with presence of grey-scale synovitis (aOR=1.27, 95% CI:1.00-1.60, and adjusted prevalence ratio [aPR]=1.26, 95% CI:1.10-1.44, respectively), and PDS (aOR=2.35, 95% CI:1.15-4.79, and aPR=2.34, 95% CI:1.28-4.30, respectively).
CONCLUSION: This population-based study provides more evidences for a positive association between hyperuricemia and prevalent hand synovitis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Arthritis care & research - (2024) vom: 03. Apr. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jiang, Ting [VerfasserIn] |
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Date Revised 04.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1002/acr.25342 |
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| PPN (Katalog-ID): |
NLM370603419 |
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| 245 | 1 | 0 | |a Association between hyperuricemia and ultrasound-detected hand synovitis |
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| 500 | |a published: Print-Electronic | ||
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| 520 | |a This article is protected by copyright. All rights reserved. | ||
| 520 | |a OBJECTIVE: Although hand synovitis is prevalent in the older population, the aetiology remains unclear. Hyperuricemia, a modifiable metabolic disorder, may serve as an underlying mechanism of hand synovitis, but little is known about their relationship. We assessed the association between hyperuricemia and hand synovitis in a large population-based sample | ||
| 520 | |a METHODS: We performed a cross-sectional study in Longshan County, Hunan Province, China. Hyperuricemia was defined as a serum urate >420 μmol/L in men and >360 μmol/L in women. Ultrasound examinations were performed on both hands of 4,080 participants, and both grey-scale synovitis and Power Doppler signal (PDS) were assessed using semiquantitative scores (grades 0-3). We evaluated the association of hyperuricemia with hand grey-scale synovitis (grade ≥2) and PDS (grade ≥1), respectively, adjusting for age, sex and body mass index | ||
| 520 | |a RESULTS: All required assessments for analysis were available on 3,286 participants. The prevalence of hand grey-scale synovitis was higher among participants with hyperuricemia (30.0%) than those with normouricemia (23.3%), with an adjusted odds ratio (aOR) of 1.28 (95% confidence interval [CI]:1.00-1.62). Participants with hyperuricemia also had higher prevalence of PDS (aOR=2.36, 95% CI:1.15-4.81). Furthermore, hyperuricemia positively associated, both at the hand and joint levels, with presence of grey-scale synovitis (aOR=1.27, 95% CI:1.00-1.60, and adjusted prevalence ratio [aPR]=1.26, 95% CI:1.10-1.44, respectively), and PDS (aOR=2.35, 95% CI:1.15-4.79, and aPR=2.34, 95% CI:1.28-4.30, respectively) | ||
| 520 | |a CONCLUSION: This population-based study provides more evidences for a positive association between hyperuricemia and prevalent hand synovitis | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Weng, Qianlin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yuqing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Weiya |e verfasserin |4 aut | |
| 700 | 1 | |a Doherty, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Sarmanova, Aliya |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Zidan |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Tuo |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Jiatian |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Ke |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yuqing |e verfasserin |4 aut | |
| 700 | 1 | |a Obotiba, Abasiama D |e verfasserin |4 aut | |
| 700 | 1 | |a Zeng, Chao |e verfasserin |4 aut | |
| 700 | 1 | |a Lei, Guanghua |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Jie |e verfasserin |4 aut | |
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