Role of CD34-immunopositive Microvascular Density in Juvenile Nasopharyngeal Angiofibroma
© Association of Otolaryngologists of India 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law..
Objective: To assess the microvascular density (MVD) in juvenile nasopharyngeal angiofibroma (JNA) with CD34 immunostaining and evaluate its relationship with clinico-demographic features.
Methods: This prospective study included patients with JNA undergoing endoscopic excision. The histopathological specimen was stained using CD-34 antibodies to calculate MVD. MVD and clinico-demographic features were correlated.
Results: The study included 12 patients with a median age of 15.5 years. The mean MVD was 39 vessels/high power field (range 5 to 151 vessels). MVD was significantly associated only with the volume of tumour (r = 0.65, p = 0.02). The recurrence occurred in one patient with an MVD of 107. The median follow-up was 38 months.
Conclusion: MVD is significantly associated with tumour volume in JNA, which implies a robust role of angiogenesis in the pathology of the tumour. Also, higher MVD may be a risk factor for recurrence.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:76 |
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| Enthalten in: |
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India - 76(2024), 2 vom: 03. Apr., Seite 1503-1508 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jaiswal, Avinash Shekhar [VerfasserIn] |
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| Links: |
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| Themen: |
Angiofibroma |
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| Anmerkungen: |
Date Revised 04.04.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1007/s12070-023-04331-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370561724 |
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| 520 | |a © Association of Otolaryngologists of India 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. | ||
| 520 | |a Objective: To assess the microvascular density (MVD) in juvenile nasopharyngeal angiofibroma (JNA) with CD34 immunostaining and evaluate its relationship with clinico-demographic features | ||
| 520 | |a Methods: This prospective study included patients with JNA undergoing endoscopic excision. The histopathological specimen was stained using CD-34 antibodies to calculate MVD. MVD and clinico-demographic features were correlated | ||
| 520 | |a Results: The study included 12 patients with a median age of 15.5 years. The mean MVD was 39 vessels/high power field (range 5 to 151 vessels). MVD was significantly associated only with the volume of tumour (r = 0.65, p = 0.02). The recurrence occurred in one patient with an MVD of 107. The median follow-up was 38 months | ||
| 520 | |a Conclusion: MVD is significantly associated with tumour volume in JNA, which implies a robust role of angiogenesis in the pathology of the tumour. Also, higher MVD may be a risk factor for recurrence | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Angiofibroma | |
| 650 | 4 | |a Angiogenesis | |
| 650 | 4 | |a Microvascular density | |
| 650 | 4 | |a Pathology | |
| 650 | 4 | |a Volume | |
| 700 | 1 | |a Kumar, Rakesh |e verfasserin |4 aut | |
| 700 | 1 | |a Kakkar, Aanchal |e verfasserin |4 aut | |
| 700 | 1 | |a Kumar, Rajeev |e verfasserin |4 aut | |
| 700 | 1 | |a Verma, Hitesh |e verfasserin |4 aut | |
| 700 | 1 | |a Bhalla, Ashu Seith |e verfasserin |4 aut | |
| 700 | 1 | |a Kairo, Arvind Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Thakar, Alok |e verfasserin |4 aut | |
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