Key HPI axis receptors facilitate light adaptive behavior in larval zebrafish
© 2024. The Author(s)..
The vertebrate stress response (SR) is mediated by the hypothalamic-pituitary-adrenal (HPA) axis and contributes to generating context appropriate physiological and behavioral changes. Although the HPA axis plays vital roles both in stressful and basal conditions, research has focused on the response under stress. To understand broader roles of the HPA axis in a changing environment, we characterized an adaptive behavior of larval zebrafish during ambient illumination changes. Genetic abrogation of glucocorticoid receptor (nr3c1) decreased basal locomotor activity in light and darkness. Some key HPI axis receptors (mc2r [ACTH receptor], nr3c1), but not nr3c2 (mineralocorticoid receptor), were required to adapt to light more efficiently but became dispensable when longer illumination was provided. Such light adaptation was more efficient in dimmer light. Our findings show that the HPI axis contributes to the SR, facilitating the phasic response and maintaining an adapted basal state, and that certain adaptations occur without HPI axis activity.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Scientific reports - 14(2024), 1 vom: 02. Apr., Seite 7759 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lee, Han B [VerfasserIn] |
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| Links: |
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| Themen: |
GAM (generalized additive models) |
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| Anmerkungen: |
Date Completed 04.04.2024 Date Revised 22.04.2024 published: Electronic UpdateOf: Res Sq. 2023 Sep 06;:. - PMID 37720015 Citation Status MEDLINE |
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| doi: |
10.1038/s41598-024-57707-6 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370550331 |
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| 245 | 1 | 0 | |a Key HPI axis receptors facilitate light adaptive behavior in larval zebrafish |
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| 500 | |a UpdateOf: Res Sq. 2023 Sep 06;:. - PMID 37720015 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024. The Author(s). | ||
| 520 | |a The vertebrate stress response (SR) is mediated by the hypothalamic-pituitary-adrenal (HPA) axis and contributes to generating context appropriate physiological and behavioral changes. Although the HPA axis plays vital roles both in stressful and basal conditions, research has focused on the response under stress. To understand broader roles of the HPA axis in a changing environment, we characterized an adaptive behavior of larval zebrafish during ambient illumination changes. Genetic abrogation of glucocorticoid receptor (nr3c1) decreased basal locomotor activity in light and darkness. Some key HPI axis receptors (mc2r [ACTH receptor], nr3c1), but not nr3c2 (mineralocorticoid receptor), were required to adapt to light more efficiently but became dispensable when longer illumination was provided. Such light adaptation was more efficient in dimmer light. Our findings show that the HPI axis contributes to the SR, facilitating the phasic response and maintaining an adapted basal state, and that certain adaptations occur without HPI axis activity | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a GAM (generalized additive models) | |
| 650 | 4 | |a GR (glucocorticoid receptor) | |
| 650 | 4 | |a Light adaptation | |
| 650 | 4 | |a Light assays | |
| 650 | 4 | |a Stress response | |
| 650 | 4 | |a Zebrafish | |
| 650 | 7 | |a Receptors, Glucocorticoid |2 NLM | |
| 700 | 1 | |a Shams, Soaleha |e verfasserin |4 aut | |
| 700 | 1 | |a Dang Thi, Viet Ha |e verfasserin |4 aut | |
| 700 | 1 | |a Boyum, Grace E |e verfasserin |4 aut | |
| 700 | 1 | |a Modhurima, Rodsy |e verfasserin |4 aut | |
| 700 | 1 | |a Hall, Emma M |e verfasserin |4 aut | |
| 700 | 1 | |a Green, Izzabella K |e verfasserin |4 aut | |
| 700 | 1 | |a Cervantes, Elizabeth M |e verfasserin |4 aut | |
| 700 | 1 | |a Miguez, Fernando E |e verfasserin |4 aut | |
| 700 | 1 | |a Clark, Karl J |e verfasserin |4 aut | |
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