Dnttip2 is essential for 18S rRNA processing and digestive organ development in zebrafish
Copyright © 2024 Elsevier Inc. All rights reserved..
Dnttip2 is one of the components of the small subunit (SSU) processome. In yeast, depletion of dnttip2 leads to an inefficient processing of pre-rRNA and a decrease in synthesis of the mature 18S rRNA. However, the biological roles of Dnttip2 in higher organisms are poorly defined. In this study, we demonstrate that dnttip2 is a maternal gene in zebrafish. Depletion of Dnttip2 leads to embryonic lethal with severe digestive organs hypoplasia. The loss of function of Dnttip2 also leads to partial defects in cleavage at the A0-site and E-site during 18S rRNA processing. In conclusion, Dnttip2 is essential for 18S rRNA processing and digestive organ development in zebrafish.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:709 |
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| Enthalten in: |
Biochemical and biophysical research communications - 709(2024) vom: 21. Apr., Seite 149838 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhou, Ru [VerfasserIn] |
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| Links: |
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| Themen: |
18S rRNA processing |
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| Anmerkungen: |
Date Completed 15.04.2024 Date Revised 15.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bbrc.2024.149838 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370543785 |
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| 520 | |a Dnttip2 is one of the components of the small subunit (SSU) processome. In yeast, depletion of dnttip2 leads to an inefficient processing of pre-rRNA and a decrease in synthesis of the mature 18S rRNA. However, the biological roles of Dnttip2 in higher organisms are poorly defined. In this study, we demonstrate that dnttip2 is a maternal gene in zebrafish. Depletion of Dnttip2 leads to embryonic lethal with severe digestive organs hypoplasia. The loss of function of Dnttip2 also leads to partial defects in cleavage at the A0-site and E-site during 18S rRNA processing. In conclusion, Dnttip2 is essential for 18S rRNA processing and digestive organ development in zebrafish | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 18S rRNA processing | |
| 650 | 4 | |a Digestive organ development | |
| 650 | 4 | |a Dnttip2 | |
| 650 | 4 | |a Zebrafish | |
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| 650 | 7 | |a Saccharomyces cerevisiae Proteins |2 NLM | |
| 650 | 7 | |a RNA Precursors |2 NLM | |
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| 700 | 1 | |a Zeng, Ni |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Baochun |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yayue |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Shuyi |e verfasserin |4 aut | |
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