Physicochemical Evaluation and Pharmacological Screening of Fernando Adenophylla Steenis Fruits
© 2024 Wiley‐VCH GmbH..
The current study aimed to evaluate the physicochemical properties of Fernandoa adenophylla. Powder studies were carried out to estimate the quantitative physicochemical characteristics of the crude drug, including moisture content, ash content, and extractive values. Using a Soxhlet apparatus and different analytical grade solvents, 3 sample extracts of a crude drug were made. To evaluate the potentially toxic nature, an acute oral toxicity study was performed as per OECD guideline no. 423. Sample extracts were tested and analyzed by ANOVA for pharmacological potential (analgesic, antipyretic, and antidiabetic) using Wister-Albino rats. Where physicochemical analysis indicated purity, quality, and presence of organic/inorganic materials in crude drug extracts, no sign of mortality was found up to 2000 mg/kg of body weight of Fernandoa adenophyllas extracts. Analgesic activity was observed in all sample extracts, whereas only chloroform and ethanolic extracts expressed antipyretic and antidiabetic potential. Ethanolic extract was found to be most potent in pharmacological potential as 200mg/kg extract dose exhibited %age pain inhibition of 55.12% and reduced body temperature from 39.78±0.03°C to 37.22±0.02°C in hyperthermic rats. A decrease in blood glucose levels up to 57.88% was observed on the 21st day of the treatment with 500mg/kg ethanolic extract.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Chemistry & biodiversity - (2024) vom: 02. Apr., Seite e202301724 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hassan, Arham [VerfasserIn] |
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| Links: |
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| Themen: |
Acute oral toxicity |
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| Anmerkungen: |
Date Revised 02.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1002/cbdv.202301724 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370531515 |
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| 520 | |a © 2024 Wiley‐VCH GmbH. | ||
| 520 | |a The current study aimed to evaluate the physicochemical properties of Fernandoa adenophylla. Powder studies were carried out to estimate the quantitative physicochemical characteristics of the crude drug, including moisture content, ash content, and extractive values. Using a Soxhlet apparatus and different analytical grade solvents, 3 sample extracts of a crude drug were made. To evaluate the potentially toxic nature, an acute oral toxicity study was performed as per OECD guideline no. 423. Sample extracts were tested and analyzed by ANOVA for pharmacological potential (analgesic, antipyretic, and antidiabetic) using Wister-Albino rats. Where physicochemical analysis indicated purity, quality, and presence of organic/inorganic materials in crude drug extracts, no sign of mortality was found up to 2000 mg/kg of body weight of Fernandoa adenophyllas extracts. Analgesic activity was observed in all sample extracts, whereas only chloroform and ethanolic extracts expressed antipyretic and antidiabetic potential. Ethanolic extract was found to be most potent in pharmacological potential as 200mg/kg extract dose exhibited %age pain inhibition of 55.12% and reduced body temperature from 39.78±0.03°C to 37.22±0.02°C in hyperthermic rats. A decrease in blood glucose levels up to 57.88% was observed on the 21st day of the treatment with 500mg/kg ethanolic extract | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Analgesic | |
| 650 | 4 | |a Antipyretic | |
| 650 | 4 | |a Fernandoa adenophylla | |
| 650 | 4 | |a Hypoglycemic | |
| 650 | 4 | |a acute oral toxicity | |
| 700 | 1 | |a Saeed, Muhammad Asad |e verfasserin |4 aut | |
| 700 | 1 | |a Zaman, Muhammad |e verfasserin |4 aut | |
| 700 | 1 | |a Aslam, Nazia |e verfasserin |4 aut | |
| 700 | 1 | |a Khan, Mahtab Ahmad |e verfasserin |4 aut | |
| 700 | 1 | |a Khan, Azmat Ali |e verfasserin |4 aut | |
| 700 | 1 | |a Alanazi, Amer M |e verfasserin |4 aut | |
| 700 | 1 | |a Kundu, Milton Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Barai, Hasi Rani |e verfasserin |4 aut | |
| 700 | 1 | |a Alexiou, Athanasios |e verfasserin |4 aut | |
| 700 | 1 | |a Papadakis, Marios |e verfasserin |4 aut | |
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