Lower serum insulin-like growth factor 2 level in patients with bipolar disorder is associated with the severity of manic symptoms during manic episodes
Copyright © 2024 Ye, Zhao, Liu, Luo, Xiong, Zhan, Li, Wei, Chen and Yang..
Objective: Accumulating evidence has indicated that neurodevelopmental defects may underlie the pathophysiology of bipolar disorder (BD). Insulin-like growth factors (IGFs) are a family of neurotrophic factors that are essential for the survival and development of neurons. The present study aims to investigate whether IGF-2 signaling is implicated in the pathophysiological processes of BD.
Method: 50 healthy controls and 78 patients with BD, including 23 patients who diagnosed acute depressive episode and 55 patients who diagnosed acute manic episode, were recruited in this study. The 17-item Hamilton Depression Rating Scale (HAMD-17) and the Young Mania Rating Scale (YMRS) were used to assess the severity of the depressive and manic symptoms, respectively. The serum IGF-2 level was determined by an enzyme-linked immunosorbent assay (ELISA). The Kolmogorov-Smirnov and Mann-Whitney U tests were used for between-group comparisons and spearman analysis was used to analyze correlations.
Results: Patients with BD had lower serum IGF-2 levels (66.08 ± 21.22 ng/ml) when compared to healthy controls (88.72 ± 31.55 ng/ml). BD patients were divided into manic episode and depressive episode subgroups. We found that serum IGF-2 levels were reduced in both the mania and depression subgroups (mania: 67.19 ± 21.52 ng/ml, depression: 63.43 ± 20.67 ng/ml; P < 0.001), while no significant difference was observed between two groups (P > 0.05). Spearman correlation analyses revealed that the levels of serum IGF-2 were negatively correlated with the YMRS scores in BD patients (r = -0.522, P < 0.001). Furthermore, IGF-2 was found to be an independent contributor to the severity of symptoms in patients with manic episodes (B = -0.610, t = -5.299, P < 0.001).
Conclusion: Lower serum IGF-2 levels were found in BD patients and correlated with the severity of the manic symptoms in these patients during manic episodes. These results suggest that reduced IGF-2 levels might be involved in the pathophysiology of BD, and serum IGF-2 could be a peripheral biomarker for the evaluation of the severity of manic symptoms in BD patients.
| Errataetall: |
ErratumIn: Front Psychiatry. 2024 Apr 12;15:1408899. - PMID 38680781 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Frontiers in psychiatry - 15(2024) vom: 29., Seite 1354999 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ye, Shi-Yi [VerfasserIn] |
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| Links: |
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| Themen: |
Bipolar disorder |
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| Anmerkungen: |
Date Revised 29.04.2024 published: Electronic-eCollection ErratumIn: Front Psychiatry. 2024 Apr 12;15:1408899. - PMID 38680781 Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3389/fpsyt.2024.1354999 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370525272 |
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| 245 | 1 | 0 | |a Lower serum insulin-like growth factor 2 level in patients with bipolar disorder is associated with the severity of manic symptoms during manic episodes |
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| 500 | |a published: Electronic-eCollection | ||
| 500 | |a ErratumIn: Front Psychiatry. 2024 Apr 12;15:1408899. - PMID 38680781 | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2024 Ye, Zhao, Liu, Luo, Xiong, Zhan, Li, Wei, Chen and Yang. | ||
| 520 | |a Objective: Accumulating evidence has indicated that neurodevelopmental defects may underlie the pathophysiology of bipolar disorder (BD). Insulin-like growth factors (IGFs) are a family of neurotrophic factors that are essential for the survival and development of neurons. The present study aims to investigate whether IGF-2 signaling is implicated in the pathophysiological processes of BD | ||
| 520 | |a Method: 50 healthy controls and 78 patients with BD, including 23 patients who diagnosed acute depressive episode and 55 patients who diagnosed acute manic episode, were recruited in this study. The 17-item Hamilton Depression Rating Scale (HAMD-17) and the Young Mania Rating Scale (YMRS) were used to assess the severity of the depressive and manic symptoms, respectively. The serum IGF-2 level was determined by an enzyme-linked immunosorbent assay (ELISA). The Kolmogorov-Smirnov and Mann-Whitney U tests were used for between-group comparisons and spearman analysis was used to analyze correlations | ||
| 520 | |a Results: Patients with BD had lower serum IGF-2 levels (66.08 ± 21.22 ng/ml) when compared to healthy controls (88.72 ± 31.55 ng/ml). BD patients were divided into manic episode and depressive episode subgroups. We found that serum IGF-2 levels were reduced in both the mania and depression subgroups (mania: 67.19 ± 21.52 ng/ml, depression: 63.43 ± 20.67 ng/ml; P < 0.001), while no significant difference was observed between two groups (P > 0.05). Spearman correlation analyses revealed that the levels of serum IGF-2 were negatively correlated with the YMRS scores in BD patients (r = -0.522, P < 0.001). Furthermore, IGF-2 was found to be an independent contributor to the severity of symptoms in patients with manic episodes (B = -0.610, t = -5.299, P < 0.001) | ||
| 520 | |a Conclusion: Lower serum IGF-2 levels were found in BD patients and correlated with the severity of the manic symptoms in these patients during manic episodes. These results suggest that reduced IGF-2 levels might be involved in the pathophysiology of BD, and serum IGF-2 could be a peripheral biomarker for the evaluation of the severity of manic symptoms in BD patients | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a manic symptoms | |
| 650 | 4 | |a serum | |
| 650 | 4 | |a severity | |
| 700 | 1 | |a Zhao, Yin |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Zhao-Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Luo, Cui-Pin |e verfasserin |4 aut | |
| 700 | 1 | |a Xiong, Jian-Wen |e verfasserin |4 aut | |
| 700 | 1 | |a Zhan, Jin-Qiong |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yi-Heng |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Chun-Nuan |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Yuan-Jian |e verfasserin |4 aut | |
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