Correlation of SARS-CoV-2 in Wastewater and Individual Testing Results in a Jail, Atlanta, Georgia, USA
Institution-level wastewater-based surveillance was implemented during the COVID-19 pandemic, including in carceral facilities. We examined the relationship between COVID-19 diagnostic test results of residents in a jail in Atlanta, Georgia, USA (average population ≈2,700), and quantitative reverse transcription PCR signal for SARS-CoV-2 in weekly wastewater samples collected during October 2021‒May 2022. The jail offered residents rapid antigen testing at entry and periodic mass screenings by reverse transcription PCR of self-collected nasal swab specimens. We aggregated individual test data, calculated the Spearman correlation coefficient, and performed logistic regression to examine the relationship between strength of SARS-CoV-2 PCR signal (cycle threshold value) in wastewater and percentage of jail population that tested positive for COVID-19. Of 13,745 nasal specimens collected, 3.9% were COVID-positive (range 0%-29.5% per week). We observed a strong inverse correlation between diagnostic test positivity and cycle threshold value (r = -0.67; p<0.01). Wastewater-based surveillance represents an effective strategy for jailwide surveillance of COVID-19.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Emerging infectious diseases - 30(2024), 13 vom: 01. Apr., Seite S21-S27 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Saber, Lindsay B [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 03.04.2024 Date Revised 04.04.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.3201/eid3013.230775 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM370511360 |
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| 520 | |a Institution-level wastewater-based surveillance was implemented during the COVID-19 pandemic, including in carceral facilities. We examined the relationship between COVID-19 diagnostic test results of residents in a jail in Atlanta, Georgia, USA (average population ≈2,700), and quantitative reverse transcription PCR signal for SARS-CoV-2 in weekly wastewater samples collected during October 2021‒May 2022. The jail offered residents rapid antigen testing at entry and periodic mass screenings by reverse transcription PCR of self-collected nasal swab specimens. We aggregated individual test data, calculated the Spearman correlation coefficient, and performed logistic regression to examine the relationship between strength of SARS-CoV-2 PCR signal (cycle threshold value) in wastewater and percentage of jail population that tested positive for COVID-19. Of 13,745 nasal specimens collected, 3.9% were COVID-positive (range 0%-29.5% per week). We observed a strong inverse correlation between diagnostic test positivity and cycle threshold value (r = -0.67; p<0.01). Wastewater-based surveillance represents an effective strategy for jailwide surveillance of COVID-19 | ||
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| 650 | 4 | |a respiratory infections | |
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| 700 | 1 | |a Kennedy, Shanika S |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Yixin |e verfasserin |4 aut | |
| 700 | 1 | |a Moore, Kyler N |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yuke |e verfasserin |4 aut | |
| 700 | 1 | |a Hilton, Stephen P |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Tylis Y |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Pengbo |e verfasserin |4 aut | |
| 700 | 1 | |a Phillips, Victoria L |e verfasserin |4 aut | |
| 700 | 1 | |a Akiyama, Matthew J |e verfasserin |4 aut | |
| 700 | 1 | |a Moe, Christine L |e verfasserin |4 aut | |
| 700 | 1 | |a Spaulding, Anne C |e verfasserin |4 aut | |
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