Approaches Towards Better Immunosuppressive Agents
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
Several classes of compounds are applied in clinics due to their immunosuppressive properties in transplantology and the treatment of autoimmune diseases. Derivatives of mycophenolic acid, corticosteroids and chemotherapeutics bearing heterocyclic moieties like methotrexate, azathioprine, mizoribine, and ruxolitinib are active substances with investigated mechanisms of action. However, improved synthetic approaches of known drugs and novel derivatives are still being reported to attempt better accessibility and therapeutic properties. In this review article, we present the synthesis of the designed chemical structures based on recent literature reports concerning novel compounds as promising immunosuppressive drugs. Moreover, some of the discussed derivers revealed also other types of activities with prospective medicinal potential.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Current topics in medicinal chemistry - (2024) vom: 29. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Walczak, Juliusz [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-proliferative activity |
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| Anmerkungen: |
Date Revised 01.04.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.2174/0115680266292661240322072908 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Several classes of compounds are applied in clinics due to their immunosuppressive properties in transplantology and the treatment of autoimmune diseases. Derivatives of mycophenolic acid, corticosteroids and chemotherapeutics bearing heterocyclic moieties like methotrexate, azathioprine, mizoribine, and ruxolitinib are active substances with investigated mechanisms of action. However, improved synthetic approaches of known drugs and novel derivatives are still being reported to attempt better accessibility and therapeutic properties. In this review article, we present the synthesis of the designed chemical structures based on recent literature reports concerning novel compounds as promising immunosuppressive drugs. Moreover, some of the discussed derivers revealed also other types of activities with prospective medicinal potential | ||
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