Expression landscape of cancer-FOXP3 and its prognostic value in pancreatic adenocarcinoma
Copyright © 2024 Elsevier B.V. All rights reserved..
FOXP3, a key identifier of Treg, has also been identified in tumor cells, which is referred to as cancer-FOXP3 (c-FOXP3). Human c-FOXP3 undergoes multiple alternative splicing events, generating several isoforms, like c-FOXP3FL and c-FOXP3Δ3. Previous research on c-FOXP3 often ignore its cellular source (immune or tumor cells) and isoform expression patterns, which may obscure our understanding of its clinical significance. Our immunohistochemistry investigations which conducted across 18 tumors using validated c-FOXP3 antibodies revealed distinct expression landscapes for c-FOXP3 and its variants, with the majority of tumors exhibited a predominantly expression of c-FOXP3Δ3. In pancreatic ductal adenocarcinoma (PDAC), we further discovered a potential link between nuclear c-FOXP3Δ3 in tumor cells and poor prognosis. Overexpression of c-FOXP3Δ3 in tumor cells was associated with metastasis. This work elucidates the expression pattern of c-FOXP3 in pan-cancer and indicates its potential as a prognostic biomarker in clinical settings, offering new perspectives for its clinical application.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:590 |
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| Enthalten in: |
Cancer letters - 590(2024) vom: 28. Mai, Seite 216838 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gong, Ruining [VerfasserIn] |
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| Links: |
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| Themen: |
Antibodies |
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| Anmerkungen: |
Date Completed 02.05.2024 Date Revised 02.05.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.canlet.2024.216838 |
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NLM370505425 |
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| 520 | |a FOXP3, a key identifier of Treg, has also been identified in tumor cells, which is referred to as cancer-FOXP3 (c-FOXP3). Human c-FOXP3 undergoes multiple alternative splicing events, generating several isoforms, like c-FOXP3FL and c-FOXP3Δ3. Previous research on c-FOXP3 often ignore its cellular source (immune or tumor cells) and isoform expression patterns, which may obscure our understanding of its clinical significance. Our immunohistochemistry investigations which conducted across 18 tumors using validated c-FOXP3 antibodies revealed distinct expression landscapes for c-FOXP3 and its variants, with the majority of tumors exhibited a predominantly expression of c-FOXP3Δ3. In pancreatic ductal adenocarcinoma (PDAC), we further discovered a potential link between nuclear c-FOXP3Δ3 in tumor cells and poor prognosis. Overexpression of c-FOXP3Δ3 in tumor cells was associated with metastasis. This work elucidates the expression pattern of c-FOXP3 in pan-cancer and indicates its potential as a prognostic biomarker in clinical settings, offering new perspectives for its clinical application | ||
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| 650 | 4 | |a Antibodies | |
| 650 | 4 | |a Cancer-FOXP3 | |
| 650 | 4 | |a Pan-cancer | |
| 650 | 4 | |a Prognosis | |
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| 700 | 1 | |a Wang, Jia |e verfasserin |4 aut | |
| 700 | 1 | |a Xing, Yihai |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jigang |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Xianghan |e verfasserin |4 aut | |
| 700 | 1 | |a Lei, Ke |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Qian |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Chenyang |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Sainan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yuxing |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Hongxia |e verfasserin |4 aut | |
| 700 | 1 | |a Ren, He |e verfasserin |4 aut | |
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