The outcomes and biliary complications of a staged biliary reconstruction in living donor liver transplantation : a propensity score matched analysis
Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved..
BACKGROUND: Uncontrolled massive bleeding and bowel edema are critical issues during liver transplantation. Temporal intra-abdominal packing with staged biliary reconstruction (SBR) yields acceptable outcomes in deceased donor liver transplantation; however, data on living donor liver transplantation (LDLT) are scarce.
METHODS: A retrospective analysis of 1269 patients who underwent LDLT was performed. After one-to-two propensity score matching, patients who underwent LDLT with SBR were compared with those who underwent LDLT with one-stage biliary reconstruction (OSBR). The primary outcomes were graft survival (GS) and overall survival (OS), and the secondary outcomes were postoperative biliary complications.
RESULTS: There were 55 and 110 patients in the SBR and OSBR groups, respectively. The median blood loss was 6500 mL in the SBR and 4875 mL in the OSBR group. Patients receiving SBR-LDLT had higher incidence of sepsis (69.0% vs. 43.6%; P < 0.01) and intra-abdominal infections (60.0% vs. 30.9%; P < 0.01). Biliary complication rates (14.5% vs. 19.1%; P = 0.47) and 1-and 5-year GS (87.27%, 74.60% vs. 83.64%, 72.71%; P = 0.98) and OS (89.09%, 78.44% vs. 84.55%, 73.70%; P = 0.752) rates were comparable between the two groups.
CONCLUSIONS: SBR could serve as a life-saving procedure for patients undergoing complex critical LDLT, with GS, OS, and biliary outcomes comparable to those of OSBR.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
HPB : the official journal of the International Hepato Pancreato Biliary Association - (2024) vom: 20. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hou, Teng-Yuan [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 31.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.hpb.2024.03.1160 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM37045927X |
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| 100 | 1 | |a Hou, Teng-Yuan |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The outcomes and biliary complications of a staged biliary reconstruction in living donor liver transplantation |b a propensity score matched analysis |
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| 500 | |a Date Revised 31.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a BACKGROUND: Uncontrolled massive bleeding and bowel edema are critical issues during liver transplantation. Temporal intra-abdominal packing with staged biliary reconstruction (SBR) yields acceptable outcomes in deceased donor liver transplantation; however, data on living donor liver transplantation (LDLT) are scarce | ||
| 520 | |a METHODS: A retrospective analysis of 1269 patients who underwent LDLT was performed. After one-to-two propensity score matching, patients who underwent LDLT with SBR were compared with those who underwent LDLT with one-stage biliary reconstruction (OSBR). The primary outcomes were graft survival (GS) and overall survival (OS), and the secondary outcomes were postoperative biliary complications | ||
| 520 | |a RESULTS: There were 55 and 110 patients in the SBR and OSBR groups, respectively. The median blood loss was 6500 mL in the SBR and 4875 mL in the OSBR group. Patients receiving SBR-LDLT had higher incidence of sepsis (69.0% vs. 43.6%; P < 0.01) and intra-abdominal infections (60.0% vs. 30.9%; P < 0.01). Biliary complication rates (14.5% vs. 19.1%; P = 0.47) and 1-and 5-year GS (87.27%, 74.60% vs. 83.64%, 72.71%; P = 0.98) and OS (89.09%, 78.44% vs. 84.55%, 73.70%; P = 0.752) rates were comparable between the two groups | ||
| 520 | |a CONCLUSIONS: SBR could serve as a life-saving procedure for patients undergoing complex critical LDLT, with GS, OS, and biliary outcomes comparable to those of OSBR | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Komorowski, Andrzej L |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Tsan-Shiun |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Yu-Cheng |e verfasserin |4 aut | |
| 700 | 1 | |a Sng, Yi-Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Yeh, Cheng-Hsi |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Wei-Feng |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Chih-Che |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Chih-Chi |e verfasserin |4 aut | |
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