Regulation of Aging and Lifespan by White Adipose Tissue
Long-term caloric restriction (CR) is an effective intervention that improves whole-body metabolism, suppresses age-related pathophysiology, and extends lifespan. Although the beneficial effects of caloric restriction mediated by growth hormone/insulin-like growth factor-1 (GH/IGF-1) have been extensively studied, the mechanisms independent of GH/IGF-1 remain largely unknown. In this review, we focus on these GH/IGF-1-independent mechanisms, with a particular emphasis on the role of sterol regulatory element-binding protein 1c (SREBP-1c). CR increases the expression of SREBP-1c through the suppression of leptin signaling and enhances downstream factors involved in fatty acid synthesis in white adipose tissue (WAT). SREBP-1c also directly and indirectly increases the expression of peroxisome proliferator-activated receptor gamma coactivator-1 alpha, a master regulator of mitochondrial biogenesis, leading to an increase in the number of mitochondria. Furthermore, SREBP-1c elevates expression of mitochondrial intermediate peptidase, which contributes to improving mitochondrial quality through the processing of sirtuin 3 into its mature form. Thus, it appears that CR exerts beneficial effects by modulating mitochondrial quantity and quality in WAT in a GH/IGF-1 signal-independent manner.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:144 |
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| Enthalten in: |
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan - 144(2024), 4 vom: 01., Seite 411-417 |
| Sprache: |
Japanisch |
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| Beteiligte Personen: |
Fukuoh, Tomoyoshi [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 02.04.2024 Date Revised 02.04.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1248/yakushi.23-00165-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM370458389 |
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| 520 | |a Long-term caloric restriction (CR) is an effective intervention that improves whole-body metabolism, suppresses age-related pathophysiology, and extends lifespan. Although the beneficial effects of caloric restriction mediated by growth hormone/insulin-like growth factor-1 (GH/IGF-1) have been extensively studied, the mechanisms independent of GH/IGF-1 remain largely unknown. In this review, we focus on these GH/IGF-1-independent mechanisms, with a particular emphasis on the role of sterol regulatory element-binding protein 1c (SREBP-1c). CR increases the expression of SREBP-1c through the suppression of leptin signaling and enhances downstream factors involved in fatty acid synthesis in white adipose tissue (WAT). SREBP-1c also directly and indirectly increases the expression of peroxisome proliferator-activated receptor gamma coactivator-1 alpha, a master regulator of mitochondrial biogenesis, leading to an increase in the number of mitochondria. Furthermore, SREBP-1c elevates expression of mitochondrial intermediate peptidase, which contributes to improving mitochondrial quality through the processing of sirtuin 3 into its mature form. Thus, it appears that CR exerts beneficial effects by modulating mitochondrial quantity and quality in WAT in a GH/IGF-1 signal-independent manner | ||
| 650 | 4 | |a Review | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a aging | |
| 650 | 4 | |a caloric restriction | |
| 650 | 4 | |a fatty acid synthesis | |
| 650 | 4 | |a mitochondria | |
| 650 | 4 | |a sterol regulatory element-binding protein 1c (SREBP-1c) | |
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| 700 | 1 | |a Nozaki, Yuka |e verfasserin |4 aut | |
| 700 | 1 | |a Mizunoe, Yuhei |e verfasserin |4 aut | |
| 700 | 1 | |a Higami, Yoshikazu |e verfasserin |4 aut | |
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