Myocardial Injury by COVID-19 Infection Assessed by Cardiovascular Magnetic Resonance Imaging - A Prospective Multicenter Study
BACKGROUND: This prospective multicenter study assessed the prevalence of myocardial injury in patients with COVID-19 using cardiac magnetic resonance imaging (CMR).Methods and Results: We prospectively screened 505 patients with moderate to severe COVID-19 disease from 7 hospitals in Japan. Of these patients, 31 (mean [±SD] age 63.5±10.4 years, 23 [74%] male) suspected of myocardial injury, based on elevated serum troponin or B-type natriuretic peptide concentrations either upon admission or 3 months after discharge, underwent CMR 3 months after discharge. The primary endpoint was the presence of myocardial injury, defined by any of the following: (1) contrast enhancement in the left or right ventricle myocardium on late gadolinium enhancement CMR; (2) left or right ventricular dysfunction (defined as <50% and <45%, respectively); and (3) pericardial thickening on contrast enhancement. The mean (±SD) duration between diagnosis and CMR was 117±16 days. The primary endpoint was observed in 13 of 31 individuals (42%), with 8 (26%) satisfying the modified Lake Louise Criteria for the diagnosis of acute myocarditis.
CONCLUSIONS: This study revealed a high incidence of myocardial injury identified by CMR in patients with moderate to severe COVID-19 and abnormal findings for cardiac biomarkers.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Circulation journal : official journal of the Japanese Circulation Society - (2024) vom: 29. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kato, Shingo [VerfasserIn] |
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| Links: |
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| Themen: |
COVID-19 |
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| Anmerkungen: |
Date Revised 31.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1253/circj.CJ-23-0729 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370458192 |
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| 520 | |a BACKGROUND: This prospective multicenter study assessed the prevalence of myocardial injury in patients with COVID-19 using cardiac magnetic resonance imaging (CMR).Methods and Results: We prospectively screened 505 patients with moderate to severe COVID-19 disease from 7 hospitals in Japan. Of these patients, 31 (mean [±SD] age 63.5±10.4 years, 23 [74%] male) suspected of myocardial injury, based on elevated serum troponin or B-type natriuretic peptide concentrations either upon admission or 3 months after discharge, underwent CMR 3 months after discharge. The primary endpoint was the presence of myocardial injury, defined by any of the following: (1) contrast enhancement in the left or right ventricle myocardium on late gadolinium enhancement CMR; (2) left or right ventricular dysfunction (defined as <50% and <45%, respectively); and (3) pericardial thickening on contrast enhancement. The mean (±SD) duration between diagnosis and CMR was 117±16 days. The primary endpoint was observed in 13 of 31 individuals (42%), with 8 (26%) satisfying the modified Lake Louise Criteria for the diagnosis of acute myocarditis | ||
| 520 | |a CONCLUSIONS: This study revealed a high incidence of myocardial injury identified by CMR in patients with moderate to severe COVID-19 and abnormal findings for cardiac biomarkers | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Cardiac magnetic resonance imaging | |
| 650 | 4 | |a Myocardial injury | |
| 650 | 4 | |a Myocarditis | |
| 700 | 1 | |a Kitai, Takeshi |e verfasserin |4 aut | |
| 700 | 1 | |a Utsunomiya, Daisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Azuma, Mai |e verfasserin |4 aut | |
| 700 | 1 | |a Fukui, Kazuki |e verfasserin |4 aut | |
| 700 | 1 | |a Hagiwara, Eri |e verfasserin |4 aut | |
| 700 | 1 | |a Ogura, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Ishibashi, Yuki |e verfasserin |4 aut | |
| 700 | 1 | |a Okada, Taiji |e verfasserin |4 aut | |
| 700 | 1 | |a Kitakata, Hiroki |e verfasserin |4 aut | |
| 700 | 1 | |a Shiraishi, Yasuyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Torii, Shunsuke |e verfasserin |4 aut | |
| 700 | 1 | |a Ohashi, Koichi |e verfasserin |4 aut | |
| 700 | 1 | |a Takamatsu, Kazufumi |e verfasserin |4 aut | |
| 700 | 1 | |a Yokoyama, Akihito |e verfasserin |4 aut | |
| 700 | 1 | |a Hirata, Ken-Ichi |e verfasserin |4 aut | |
| 700 | 1 | |a Matsue, Yuya |e verfasserin |4 aut | |
| 700 | 1 | |a Node, Koichi |e verfasserin |4 aut | |
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