Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approaches
Molecule interacting with CasL 1 (MICAL1) is a crucial protein involved in cell motility, axon guidance, cytoskeletal dynamics, and gene transcription. This pan-cancer study analyzed MICAL1 across 33 cancer types using bioinformatics and experiments. Dysregulated expression, diagnostic potential, and prognostic value were assessed. Associations with tumor characteristics, immune factors, and drug sensitivity were explored. Enrichment analysis revealed MICAL1's involvement in metastasis, angiogenesis, metabolism, and immune pathways. Functional experiments demonstrated its impact on renal carcinoma cells. These findings position MICAL1 as a potential biomarker and therapeutic target in specific cancers, warranting further investigation into its role in cancer pathogenesis.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
|---|---|
| Enthalten in: |
Cell adhesion & migration - 18(2024), 1 vom: 30. Apr., Seite 1-17 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Li, Canxuan [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Bioinformatics |
|---|
| Anmerkungen: |
Date Completed 01.04.2024 Date Revised 03.04.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1080/19336918.2024.2335682 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM370450426 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM370450426 | ||
| 003 | DE-627 | ||
| 005 | 20240403235857.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240331s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/19336918.2024.2335682 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1363.xml |
| 035 | |a (DE-627)NLM370450426 | ||
| 035 | |a (NLM)38555517 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Li, Canxuan |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approaches |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 01.04.2024 | ||
| 500 | |a Date Revised 03.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Molecule interacting with CasL 1 (MICAL1) is a crucial protein involved in cell motility, axon guidance, cytoskeletal dynamics, and gene transcription. This pan-cancer study analyzed MICAL1 across 33 cancer types using bioinformatics and experiments. Dysregulated expression, diagnostic potential, and prognostic value were assessed. Associations with tumor characteristics, immune factors, and drug sensitivity were explored. Enrichment analysis revealed MICAL1's involvement in metastasis, angiogenesis, metabolism, and immune pathways. Functional experiments demonstrated its impact on renal carcinoma cells. These findings position MICAL1 as a potential biomarker and therapeutic target in specific cancers, warranting further investigation into its role in cancer pathogenesis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bioinformatics | |
| 650 | 4 | |a MICAL1 | |
| 650 | 4 | |a immune pathways | |
| 650 | 4 | |a pan-cancer | |
| 650 | 4 | |a tumor immune microenvironment | |
| 650 | 7 | |a MICAL1 protein, human |2 NLM | |
| 650 | 7 | |a EC 1.- |2 NLM | |
| 650 | 7 | |a Calponins |2 NLM | |
| 650 | 7 | |a Mixed Function Oxygenases |2 NLM | |
| 650 | 7 | |a EC 1.- |2 NLM | |
| 650 | 7 | |a Microfilament Proteins |2 NLM | |
| 700 | 1 | |a Xiao, Yunfei |e verfasserin |4 aut | |
| 700 | 1 | |a Kong, Jianqiu |e verfasserin |4 aut | |
| 700 | 1 | |a Lai, Cong |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Zhiliang |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Zhuohang |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Weibin |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cell adhesion & migration |d 2007 |g 18(2024), 1 vom: 30. Apr., Seite 1-17 |w (DE-627)NLM186856768 |x 1933-6926 |7 nnns |
| 773 | 1 | 8 | |g volume:18 |g year:2024 |g number:1 |g day:30 |g month:04 |g pages:1-17 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/19336918.2024.2335682 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 18 |j 2024 |e 1 |b 30 |c 04 |h 1-17 | ||