Expression and influence of KATP in umbilical artery smooth muscle cells of patients with hypertensive disorders of pregnancy
© 2024. The Author(s)..
The objective of this study is to investigate the expression and influence of adenosine triphosphate-sensitive potassium channel (KATP) in human umbilical arterial smooth muscle cells (HUASMCs) of patients with hypertensive disorders of pregnancy (HDP). Western blotting was used to detect the protein expression levels of KATP inwardly rectifying potassium channel (Kir)6.1 and sulphonylurea receptor (SUR)2B subunits in HUASMCs from patients with normal parturients (NP), gestational hypertension (GH), chronic hypertension (CH), preeclampsia (PE) and chronic hypertension with superimposed preeclampsia (CHSP), respectively. There was no significant difference in the protein expression of Kir6.1 subunit in NP group, GH group, CH group, PE group and CHSP group (P > 0.05). The protein expression of SUR2B subunit was gradually decreased in NP group, GH group, CH group, PE group and CHSP group, with statistically significant difference among the groups (P < 0.05). The altered expression level of KATP SUR2B subunit may be involved in the pathogenesis of HDP. The severity of HDP may be related to the degree of decrease of SUR2B subunit.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Scientific reports - 14(2024), 1 vom: 29. März, Seite 7517 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yin, Benlan [VerfasserIn] |
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| Links: |
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| Themen: |
8L70Q75FXE |
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| Anmerkungen: |
Date Completed 01.04.2024 Date Revised 02.04.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41598-024-57885-3 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370430077 |
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| 245 | 1 | 0 | |a Expression and influence of KATP in umbilical artery smooth muscle cells of patients with hypertensive disorders of pregnancy |
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| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024. The Author(s). | ||
| 520 | |a The objective of this study is to investigate the expression and influence of adenosine triphosphate-sensitive potassium channel (KATP) in human umbilical arterial smooth muscle cells (HUASMCs) of patients with hypertensive disorders of pregnancy (HDP). Western blotting was used to detect the protein expression levels of KATP inwardly rectifying potassium channel (Kir)6.1 and sulphonylurea receptor (SUR)2B subunits in HUASMCs from patients with normal parturients (NP), gestational hypertension (GH), chronic hypertension (CH), preeclampsia (PE) and chronic hypertension with superimposed preeclampsia (CHSP), respectively. There was no significant difference in the protein expression of Kir6.1 subunit in NP group, GH group, CH group, PE group and CHSP group (P > 0.05). The protein expression of SUR2B subunit was gradually decreased in NP group, GH group, CH group, PE group and CHSP group, with statistically significant difference among the groups (P < 0.05). The altered expression level of KATP SUR2B subunit may be involved in the pathogenesis of HDP. The severity of HDP may be related to the degree of decrease of SUR2B subunit | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Hypertensive disorders | |
| 650 | 4 | |a KATP | |
| 650 | 4 | |a Pregnancy | |
| 650 | 4 | |a Umbilical artery | |
| 650 | 7 | |a Sulfonylurea Receptors |2 NLM | |
| 650 | 7 | |a Adenosine Triphosphate |2 NLM | |
| 650 | 7 | |a 8L70Q75FXE |2 NLM | |
| 650 | 7 | |a KATP Channels |2 NLM | |
| 700 | 1 | |a Yu, Xiaotong |e verfasserin |4 aut | |
| 700 | 1 | |a Fu, Xiaodong |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Xiyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Xiao, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Linli |e verfasserin |4 aut | |
| 700 | 1 | |a Nie, Yunying |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yujiao |e verfasserin |4 aut | |
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