Exacerbated gastrointestinal symptoms and long COVID in IBD patients with SARS-CoV-2 infection : A multi-center study from taiwan
Copyright © 2024 Formosan Medical Association. Published by Elsevier B.V. All rights reserved..
BACKGROUND/PURPOSE: Limited studies have addressed the exacerbation of symptoms and long COVID in inflammatory bowel disease (IBD) patients following non-severe COVID-19 infection, particularly with post-COVID-19 vaccination. We aim to investigate factors associated with exacerbated gastrointestinal symptoms (EGS) and long COVID in IBD patients with non-severe COVID-19, which is most common situation in daily practice.
METHODS: This is an observational study by multiple centers in Taiwan from May 2020 to March 2023. We collected clinical manifestation, data, and medication information from IBD patients with non-severe COVID-19. EGS was defined as increased frequency of diarrhea, bloody stool, and abdomen pain within 14 days after SARS-COV-2 infection. Long COVID was defined following the guidelines of the World Health Organization.
RESULTS: Out of 90 patients, most of them (88.9%) received at least standard two doses of COVID-19 vaccination and the majority (87.8%) were mild diseases of COVID-19.30% of patients experienced EGS during COVID-19 with higher ESR levels serving as a predictive factor (Odds ratio: 3.6, 95% confidence interval: 1.2-10.5, P = 0.02). 38.1% of those patients developed long COVID. The patients who experienced EGS during COVID-19 and with a history of longer IBD duration showed a significant association with long COVID (p = 0.03 and p = 0.02).
CONCLUSIONS: Our study revealed that EGS and long COVID occurred in one third of IBD patients with non-severe COVID-19, even though most of them had received the standard plus booster vaccination. We identified associated factors for EGS and long COVID, emphasizing the importance of post-COVID-19 follow-up in IBD patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Journal of the Formosan Medical Association = Taiwan yi zhi - (2024) vom: 28. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tsai, Tsung-Yu [VerfasserIn] |
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| Links: |
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| Themen: |
Exacerbated GI-Related symptoms |
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| Anmerkungen: |
Date Revised 29.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.jfma.2024.03.016 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370428188 |
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| 100 | 1 | |a Tsai, Tsung-Yu |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Exacerbated gastrointestinal symptoms and long COVID in IBD patients with SARS-CoV-2 infection |b A multi-center study from taiwan |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2024 Formosan Medical Association. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND/PURPOSE: Limited studies have addressed the exacerbation of symptoms and long COVID in inflammatory bowel disease (IBD) patients following non-severe COVID-19 infection, particularly with post-COVID-19 vaccination. We aim to investigate factors associated with exacerbated gastrointestinal symptoms (EGS) and long COVID in IBD patients with non-severe COVID-19, which is most common situation in daily practice | ||
| 520 | |a METHODS: This is an observational study by multiple centers in Taiwan from May 2020 to March 2023. We collected clinical manifestation, data, and medication information from IBD patients with non-severe COVID-19. EGS was defined as increased frequency of diarrhea, bloody stool, and abdomen pain within 14 days after SARS-COV-2 infection. Long COVID was defined following the guidelines of the World Health Organization | ||
| 520 | |a RESULTS: Out of 90 patients, most of them (88.9%) received at least standard two doses of COVID-19 vaccination and the majority (87.8%) were mild diseases of COVID-19.30% of patients experienced EGS during COVID-19 with higher ESR levels serving as a predictive factor (Odds ratio: 3.6, 95% confidence interval: 1.2-10.5, P = 0.02). 38.1% of those patients developed long COVID. The patients who experienced EGS during COVID-19 and with a history of longer IBD duration showed a significant association with long COVID (p = 0.03 and p = 0.02) | ||
| 520 | |a CONCLUSIONS: Our study revealed that EGS and long COVID occurred in one third of IBD patients with non-severe COVID-19, even though most of them had received the standard plus booster vaccination. We identified associated factors for EGS and long COVID, emphasizing the importance of post-COVID-19 follow-up in IBD patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Exacerbated GI-Related symptoms | |
| 650 | 4 | |a Inflammatory bowel disease | |
| 650 | 4 | |a Long COVID | |
| 700 | 1 | |a Wu, Jia-Feng |e verfasserin |4 aut | |
| 700 | 1 | |a Weng, Meng-Tzu |e verfasserin |4 aut | |
| 700 | 1 | |a Chuang, Chiao-Hsiung |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Tien-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Tai, Wei-Chen |e verfasserin |4 aut | |
| 700 | 1 | |a Tai, Chi-Ming |e verfasserin |4 aut | |
| 700 | 1 | |a Chung, Chen-Shuan |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Chih-Cheng |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Ching-Pin |e verfasserin |4 aut | |
| 700 | 1 | |a Tsai, Yuan-Yao |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Shu-Chen |e verfasserin |4 aut | |
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