Studies in Solid Solution Formation between Acetaminophen and Povidone and Mouth mouth-dissolving Strip Formulation
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
INTRODUCTION: This invention reports the solubilization of Acetaminophen (ACM) within the Povidone (PVP K30) in the solid state for the first time. First-generation solid dispersions (SDs) were attempted with a different ratio of PVP K:30:ACM. SDs prepared were transparent, suggesting a solid solution (SS) formation, which was a serendipitous discovery.
METHODS: A minimum ratio of 1.25:1 PVP K30: ACM was required to form stable SS, suggesting discontinuous SS. A computational complex prediction tool, Fourier Transform Infrared Spectroscopy (FTIR), and Differential scanning calorimetry (DSC) confirmed the SS formation.
RESULTS: The oral strip formulation was developed from the PVP K30: ACM SS using Polyvinyl alcohol as a film-former found to be optimum concerning physicochemical properties, offering rapid drug dissolution and taste masking. The developed strip is suitable for delivery of children's dose (100-150 mg).
CONCLUSION: The developed SS can also be formulated as tablets, capsules, and oral dissolving tablets to deliver adult doses with improved therapeutic benefits and patient compliance.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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Enthalten in: |
Current pharmaceutical design - (2024) vom: 28. März |
Sprache: |
Englisch |
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Beteiligte Personen: |
Shahiwala, Aliasgar [VerfasserIn] |
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Links: |
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Themen: |
Journal Article |
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Anmerkungen: |
Date Revised 29.03.2024 published: Print-Electronic Citation Status Publisher |
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doi: |
10.2174/0113816128297499240321034304 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM370405811 |
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520 | |a INTRODUCTION: This invention reports the solubilization of Acetaminophen (ACM) within the Povidone (PVP K30) in the solid state for the first time. First-generation solid dispersions (SDs) were attempted with a different ratio of PVP K:30:ACM. SDs prepared were transparent, suggesting a solid solution (SS) formation, which was a serendipitous discovery | ||
520 | |a METHODS: A minimum ratio of 1.25:1 PVP K30: ACM was required to form stable SS, suggesting discontinuous SS. A computational complex prediction tool, Fourier Transform Infrared Spectroscopy (FTIR), and Differential scanning calorimetry (DSC) confirmed the SS formation | ||
520 | |a RESULTS: The oral strip formulation was developed from the PVP K30: ACM SS using Polyvinyl alcohol as a film-former found to be optimum concerning physicochemical properties, offering rapid drug dissolution and taste masking. The developed strip is suitable for delivery of children's dose (100-150 mg) | ||
520 | |a CONCLUSION: The developed SS can also be formulated as tablets, capsules, and oral dissolving tablets to deliver adult doses with improved therapeutic benefits and patient compliance | ||
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