Role of FoxO1 in Acne and Effect of Isotretinoin on FoxO1 Expression
Copyright: © 2024 Indian Dermatology Online Journal..
Background: Nodulocystic acne is a severe type of acne that is known to improve after treatment with isotretinoin. Melnik has hypothesized a unifying concept on the mechanism of acne pathogenesis involving altered expression of Forkhead box O transcription factor (FoxO1) and role of isotretinoin in improving acne via modulating this pathway.
Aim: To evaluate the pathway proposed by Melnik in acne pathogenesis by analysing the difference in the expression of FoxO1, peroxisome proliferator-activated receptor (PPARγ), and androgen receptor (AR) between acne patients and non-acne controls and the effect of treatment with isotretinoin on change in expression of these genes in acne patients.
Results: The gene expression of FoxO1 was non significantly higher in acne patients as compared to controls. After treatment with isotretinoin, a significant decrease in FoxO1 expression in acne patients at mRNA (P = 0.05) level was observed. There was a significant decrease in grade 3 positivity of FoxO1 at protein level (P = 0.0009). A decrease in androgen receptor positivity (P = 0.055) at protein level was also observed.
Conclusion: Reduction in FoxO1 expression appears to be an important mechanism of action of isotretinoin in acne.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Indian dermatology online journal - 15(2024), 2 vom: 05. März, Seite 252-254 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kamboj, Parul [VerfasserIn] |
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| Links: |
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| Themen: |
Acne |
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| Anmerkungen: |
Date Revised 30.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.4103/idoj.idoj_455_23 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370403460 |
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| 500 | |a Date Revised 30.03.2024 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright: © 2024 Indian Dermatology Online Journal. | ||
| 520 | |a Background: Nodulocystic acne is a severe type of acne that is known to improve after treatment with isotretinoin. Melnik has hypothesized a unifying concept on the mechanism of acne pathogenesis involving altered expression of Forkhead box O transcription factor (FoxO1) and role of isotretinoin in improving acne via modulating this pathway | ||
| 520 | |a Aim: To evaluate the pathway proposed by Melnik in acne pathogenesis by analysing the difference in the expression of FoxO1, peroxisome proliferator-activated receptor (PPARγ), and androgen receptor (AR) between acne patients and non-acne controls and the effect of treatment with isotretinoin on change in expression of these genes in acne patients | ||
| 520 | |a Results: The gene expression of FoxO1 was non significantly higher in acne patients as compared to controls. After treatment with isotretinoin, a significant decrease in FoxO1 expression in acne patients at mRNA (P = 0.05) level was observed. There was a significant decrease in grade 3 positivity of FoxO1 at protein level (P = 0.0009). A decrease in androgen receptor positivity (P = 0.055) at protein level was also observed | ||
| 520 | |a Conclusion: Reduction in FoxO1 expression appears to be an important mechanism of action of isotretinoin in acne | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acne | |
| 650 | 4 | |a FoxO1 | |
| 650 | 4 | |a androgen receptor | |
| 650 | 4 | |a isotretinoin | |
| 650 | 4 | |a peroxisome proliferator-activated receptor | |
| 700 | 1 | |a Khullar, Geeti |e verfasserin |4 aut | |
| 700 | 1 | |a Handa, Sanjeev |e verfasserin |4 aut | |
| 700 | 1 | |a Pal, Arnab |e verfasserin |4 aut | |
| 700 | 1 | |a Saikia, Uma Nahar |e verfasserin |4 aut | |
| 700 | 1 | |a De, Dipankar |e verfasserin |4 aut | |
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