The hierarchical taxonomy of psychopathology in clinical high risk for psychosis : Validation and extension
The Hierarchical Taxonomy of Psychopathology (HiTOP) consortium's transdiagnostic dimensional model of psychopathology has considerable support; however, this model has been underresearched in individuals at clinical high risk for psychosis (CHR-P), a population that may advance the model. CHR-P individuals not only have attenuated psychotic symptoms that vary in severity, but also have many comorbid diagnoses and varied clinical outcomes, including disorders with uncertain relations to HiTOP (e.g., obsessive-compulsive disorder). The present study used self-report and interview data from North American Prodrome Longitudinal Study-3 (710 CHR, 96 controls) to replicate the HiTOP model and test specific hypotheses regarding disorders with uncertain relations to its dimensions. Additionally, the present study examined the HiTOP model in relation to childhood trauma, declines in social functioning, and development of full psychosis. Confirmatory factor analysis indicated that the HiTOP model's fit was nearly adequate (e.g., comparative fit index = .89), though several theory-relevant modifications were indicated. Additionally, specific tests were conducted to gain a more fine-grained perspective on how disorders with less clear prior evidence were related to the HiTOP model. Notable findings from these analyses include bipolar spectrum disorders relating to the psychosis super spectrum (i.e., .39 loading), and obsessive-compulsive disorder showing a complex pattern of loadings (e.g., internalizing and psychosis). The final model parsimoniously accounted for childhood trauma (e.g., super spectra rs = .22-.32), associations with current functioning, and predicted future conversion to a psychotic disorder (e.g., super spectra R² = .13). Overall, these results inform the HiTOP model and suggest its promise for CHR-P research. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:133 |
|---|---|
| Enthalten in: |
Journal of psychopathology and clinical science - 133(2024), 3 vom: 16. Apr., Seite 235-244 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Williams, Trevor F [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 16.04.2024 Date Revised 16.04.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1037/abn0000893 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM370361571 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM370361571 | ||
| 003 | DE-627 | ||
| 005 | 20240416232848.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240329s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1037/abn0000893 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1377.xml |
| 035 | |a (DE-627)NLM370361571 | ||
| 035 | |a (NLM)38546628 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Williams, Trevor F |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The hierarchical taxonomy of psychopathology in clinical high risk for psychosis |b Validation and extension |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 16.04.2024 | ||
| 500 | |a Date Revised 16.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The Hierarchical Taxonomy of Psychopathology (HiTOP) consortium's transdiagnostic dimensional model of psychopathology has considerable support; however, this model has been underresearched in individuals at clinical high risk for psychosis (CHR-P), a population that may advance the model. CHR-P individuals not only have attenuated psychotic symptoms that vary in severity, but also have many comorbid diagnoses and varied clinical outcomes, including disorders with uncertain relations to HiTOP (e.g., obsessive-compulsive disorder). The present study used self-report and interview data from North American Prodrome Longitudinal Study-3 (710 CHR, 96 controls) to replicate the HiTOP model and test specific hypotheses regarding disorders with uncertain relations to its dimensions. Additionally, the present study examined the HiTOP model in relation to childhood trauma, declines in social functioning, and development of full psychosis. Confirmatory factor analysis indicated that the HiTOP model's fit was nearly adequate (e.g., comparative fit index = .89), though several theory-relevant modifications were indicated. Additionally, specific tests were conducted to gain a more fine-grained perspective on how disorders with less clear prior evidence were related to the HiTOP model. Notable findings from these analyses include bipolar spectrum disorders relating to the psychosis super spectrum (i.e., .39 loading), and obsessive-compulsive disorder showing a complex pattern of loadings (e.g., internalizing and psychosis). The final model parsimoniously accounted for childhood trauma (e.g., super spectra rs = .22-.32), associations with current functioning, and predicted future conversion to a psychotic disorder (e.g., super spectra R² = .13). Overall, these results inform the HiTOP model and suggest its promise for CHR-P research. (PsycInfo Database Record (c) 2024 APA, all rights reserved) | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Williams, Alexander L |e verfasserin |4 aut | |
| 700 | 1 | |a Cowan, Henry R |e verfasserin |4 aut | |
| 700 | 1 | |a Walker, Elaine F |e verfasserin |4 aut | |
| 700 | 1 | |a Cannon, Tyrone D |e verfasserin |4 aut | |
| 700 | 1 | |a Bearden, Carrie E |e verfasserin |4 aut | |
| 700 | 1 | |a Keshavan, Matcheri |e verfasserin |4 aut | |
| 700 | 1 | |a Cornblatt, Barbara A |e verfasserin |4 aut | |
| 700 | 1 | |a Addington, Jean |e verfasserin |4 aut | |
| 700 | 1 | |a Woods, Scott W |e verfasserin |4 aut | |
| 700 | 1 | |a Perkins, Diana O |e verfasserin |4 aut | |
| 700 | 1 | |a Mathalon, Daniel H |e verfasserin |4 aut | |
| 700 | 1 | |a Cadenhead, Kristin S |e verfasserin |4 aut | |
| 700 | 1 | |a Stone, William S |e verfasserin |4 aut | |
| 700 | 1 | |a Mittal, Vijay A |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of psychopathology and clinical science |d 2022 |g 133(2024), 3 vom: 16. Apr., Seite 235-244 |w (DE-627)NLM317480685 |x 2769-755X |7 nnns |
| 773 | 1 | 8 | |g volume:133 |g year:2024 |g number:3 |g day:16 |g month:04 |g pages:235-244 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1037/abn0000893 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 133 |j 2024 |e 3 |b 16 |c 04 |h 235-244 | ||