Vitamin A Positively Correlates with Secretory Immunoglobulin A : A Cross-Sectional Study in Omicron COVID-19 Outpatients
Background: Respiratory tract infections remain among the leading causes of mortality worldwide. The COVID-19 pandemic has highlighted the importance of mucosal immunity in defending against infectious agents. Vitamin A is known to influence the production of secretory immunoglobulin A (SIgA) predominantly in the gut, where it is a critical component of the first line of defense on mucosal surfaces. Methods: This cross-sectional study, conducted 14 days post-positive COVID-19 diagnosis, aimed to determine the relationship between the nutritional status of vitamin A and SIgA levels in COVID-19 outpatients. Serum and saliva samples were collected. Vitamin A nutritional status was determined based on the assessment of dietary intake and the analysis of retinol-binding protein 4 (RBP4). SIgA levels were analyzed from salivary samples. In addition, serum antibodies were analyzed. Results: Dietary vitamin A intake and RBP4 levels positively correlated with SIgA. Patients with higher vitamin A intake showed higher SIgA/IgG1 and SIgA/IgG3 ratios, while those with higher RBP4 levels showed higher SIgA/IgM, SIgA/IgG1, and SIgA/IgG2 ratios. Conclusions: These findings underscore a significant correlation between vitamin A nutritional status and SIgA levels in COVID-19 outpatients, which may suggest the potential importance of maintaining optimal vitamin A levels for the prevention of viral infections.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Journal of clinical medicine - 13(2024), 6 vom: 07. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Turrubiates-Hernández, Francisco Javier [VerfasserIn] |
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| Links: |
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| Themen: |
Antibodies |
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| Anmerkungen: |
Date Revised 30.03.2024 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/jcm13061538 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM370313062 |
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| 520 | |a Background: Respiratory tract infections remain among the leading causes of mortality worldwide. The COVID-19 pandemic has highlighted the importance of mucosal immunity in defending against infectious agents. Vitamin A is known to influence the production of secretory immunoglobulin A (SIgA) predominantly in the gut, where it is a critical component of the first line of defense on mucosal surfaces. Methods: This cross-sectional study, conducted 14 days post-positive COVID-19 diagnosis, aimed to determine the relationship between the nutritional status of vitamin A and SIgA levels in COVID-19 outpatients. Serum and saliva samples were collected. Vitamin A nutritional status was determined based on the assessment of dietary intake and the analysis of retinol-binding protein 4 (RBP4). SIgA levels were analyzed from salivary samples. In addition, serum antibodies were analyzed. Results: Dietary vitamin A intake and RBP4 levels positively correlated with SIgA. Patients with higher vitamin A intake showed higher SIgA/IgG1 and SIgA/IgG3 ratios, while those with higher RBP4 levels showed higher SIgA/IgM, SIgA/IgG1, and SIgA/IgG2 ratios. Conclusions: These findings underscore a significant correlation between vitamin A nutritional status and SIgA levels in COVID-19 outpatients, which may suggest the potential importance of maintaining optimal vitamin A levels for the prevention of viral infections | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a retinol-binding protein | |
| 650 | 4 | |a secretory IgA | |
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| 700 | 1 | |a García-Arellano, Samuel |e verfasserin |4 aut | |
| 700 | 1 | |a Herrera-Jiménez, Laura Elena |e verfasserin |4 aut | |
| 700 | 1 | |a González-Estevez, Guillermo |e verfasserin |4 aut | |
| 700 | 1 | |a Márquez-Sandoval, Fabiola |e verfasserin |4 aut | |
| 700 | 1 | |a Padilla-Bórquez, Diana Lourdes |e verfasserin |4 aut | |
| 700 | 1 | |a Ceja-Gálvez, Hazael Ramiro |e verfasserin |4 aut | |
| 700 | 1 | |a Vega-Magaña, Natali |e verfasserin |4 aut | |
| 700 | 1 | |a Nicoletti, Ferdinando |e verfasserin |4 aut | |
| 700 | 1 | |a Muñoz-Ríos, Guillermina |e verfasserin |4 aut | |
| 700 | 1 | |a Muñoz-Valle, José Francisco |e verfasserin |4 aut | |
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