Early Intensive Neurorehabilitation in Traumatic Peripheral Nerve Injury-State of the Art
Traumatic nerve injuries are common lesions that affect several hundred thousand humans, as well as dogs and cats. The assessment of nerve regeneration through animal models may provide information for translational research and future therapeutic options that can be applied mutually in veterinary and human medicine, from a One Health perspective. This review offers a hands-on vision of the non-invasive and conservative approaches to peripheral nerve injury, focusing on the role of neurorehabilitation in nerve repair and regeneration. The peripheral nerve injury may lead to hypersensitivity, allodynia and hyperalgesia, with the possibility of joint contractures, decreasing functionality and impairing the quality of life. The question remains regarding how to improve nerve repair with surgical possibilities, but also considering electrical stimulation modalities by modulating sensory feedback, upregulation of BDNF, GFNF, TrKB and adenosine monophosphate, maintaining muscle mass and modulating fatigue. This could be improved by the positive synergetic effect of exercises and physical activity with locomotor training, and other physical modalities (low-level laser therapy, ultrasounds, pulsed electromagnetic fields, electroacupuncture and others). In addition, the use of cell-based therapies is an innovative treatment tool in this field. These strategies may help avoid situations of permanent monoplegic limbs that could lead to amputation.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
|---|---|
| Enthalten in: |
Animals : an open access journal from MDPI - 14(2024), 6 vom: 13. März |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Gouveia, Débora [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Electrical stimulation |
|---|
| Anmerkungen: |
Date Revised 30.03.2024 published: Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.3390/ani14060884 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM370295242 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM370295242 | ||
| 003 | DE-627 | ||
| 005 | 20240331001513.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240329s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/ani14060884 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1357.xml |
| 035 | |a (DE-627)NLM370295242 | ||
| 035 | |a (NLM)38539981 | ||
| 035 | |a (PII)884 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Gouveia, Débora |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Early Intensive Neurorehabilitation in Traumatic Peripheral Nerve Injury-State of the Art |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 30.03.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Traumatic nerve injuries are common lesions that affect several hundred thousand humans, as well as dogs and cats. The assessment of nerve regeneration through animal models may provide information for translational research and future therapeutic options that can be applied mutually in veterinary and human medicine, from a One Health perspective. This review offers a hands-on vision of the non-invasive and conservative approaches to peripheral nerve injury, focusing on the role of neurorehabilitation in nerve repair and regeneration. The peripheral nerve injury may lead to hypersensitivity, allodynia and hyperalgesia, with the possibility of joint contractures, decreasing functionality and impairing the quality of life. The question remains regarding how to improve nerve repair with surgical possibilities, but also considering electrical stimulation modalities by modulating sensory feedback, upregulation of BDNF, GFNF, TrKB and adenosine monophosphate, maintaining muscle mass and modulating fatigue. This could be improved by the positive synergetic effect of exercises and physical activity with locomotor training, and other physical modalities (low-level laser therapy, ultrasounds, pulsed electromagnetic fields, electroacupuncture and others). In addition, the use of cell-based therapies is an innovative treatment tool in this field. These strategies may help avoid situations of permanent monoplegic limbs that could lead to amputation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a PNI | |
| 650 | 4 | |a electrical stimulation | |
| 650 | 4 | |a exercises | |
| 650 | 4 | |a locomotor training | |
| 650 | 4 | |a nerve repair | |
| 650 | 4 | |a neurorehabilitation | |
| 650 | 4 | |a physical modalities | |
| 700 | 1 | |a Cardoso, Ana |e verfasserin |4 aut | |
| 700 | 1 | |a Carvalho, Carla |e verfasserin |4 aut | |
| 700 | 1 | |a Oliveira, Ana Catarina |e verfasserin |4 aut | |
| 700 | 1 | |a Almeida, António |e verfasserin |4 aut | |
| 700 | 1 | |a Gamboa, Óscar |e verfasserin |4 aut | |
| 700 | 1 | |a Lopes, Bruna |e verfasserin |4 aut | |
| 700 | 1 | |a Coelho, André |e verfasserin |4 aut | |
| 700 | 1 | |a Alvites, Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Varejão, Artur Severo |e verfasserin |4 aut | |
| 700 | 1 | |a Maurício, Ana Colette |e verfasserin |4 aut | |
| 700 | 1 | |a Ferreira, António |e verfasserin |4 aut | |
| 700 | 1 | |a Martins, Ângela |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Animals : an open access journal from MDPI |d 2010 |g 14(2024), 6 vom: 13. März |w (DE-627)NLM241007941 |x 2076-2615 |7 nnns |
| 773 | 1 | 8 | |g volume:14 |g year:2024 |g number:6 |g day:13 |g month:03 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3390/ani14060884 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 14 |j 2024 |e 6 |b 13 |c 03 | ||