Effectiveness of Helmet-CPAP in mild to moderate coronavirus type 2 hypoxemia : An observational study
Copyright © 2024 Elsevier España, S.L.U. and SEMICYUC. All rights reserved..
OBJECTIVE: To determine the relative effectiveness of Helmet-CPAP (H_CPAP) with respect to high-flow nasal cannula oxygen therapy (HFNO) in avoiding greater need for intubation or mortality in a medium complexity hospital in Chile during the year 2021.
DESIGN: Cohort analytical study, single center.
SETTING: Units other than intensive care units.
PATIENTS: Records of adults with mild to moderate hypoxemia due to coronavirus type 2.
INTERVENTIONS: None.
MAIN VARIABLES OF INTEREST: Need for intubation or mortality.
RESULTS: 159 patients were included in the study, with a ratio by support of 2:10 (H_CPAP:HFNO). The 46.5% were women, with no significant differences by sex according to support (p = 0.99, Fisher test). The APACHE II score, for HFNO, had a median of 10.5, 3.5 units higher than H_CPAP (p < 0.01, Wilcoxon rank sum). The risk of intubation in HFNO was 42.1% and in H_CPAP 3.8%, with a significant risk reduction of 91% (95% CI: 36.9%-98.7%; p < 0.01). APACHE II does not modify or confound the support and intubation relationship (p > 0.2, binomial regression); however, it does confound the support and mortality relationship (p = 0.82, RR homogeneity test). Despite a 79.1% reduction in mortality risk with H_CPAP, this reduction was not statistically significant (p = 0.11, binomial regression).
CONCLUSIONS: The use of Helmet CPAP, when compared to HFNO, was an effective therapeutic ventilatory support strategy to reduce the risk of intubation in patients with mild to moderate hypoxemia caused by coronavirus type 2 in inpatient units other than intensive care. The limitations associated with the difference in size, age and severity between the arms could generate bias.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
Medicina intensiva - (2024) vom: 26. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fajardo-Campoverdi, Aurio [VerfasserIn] |
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| Links: |
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| Themen: |
Acute Respiratory Distress Syndrome (ARDS) |
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| Anmerkungen: |
Date Revised 27.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1016/j.medine.2024.03.007 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370280393 |
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| 245 | 1 | 0 | |a Effectiveness of Helmet-CPAP in mild to moderate coronavirus type 2 hypoxemia |b An observational study |
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| 500 | |a Date Revised 27.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a Copyright © 2024 Elsevier España, S.L.U. and SEMICYUC. All rights reserved. | ||
| 520 | |a OBJECTIVE: To determine the relative effectiveness of Helmet-CPAP (H_CPAP) with respect to high-flow nasal cannula oxygen therapy (HFNO) in avoiding greater need for intubation or mortality in a medium complexity hospital in Chile during the year 2021 | ||
| 520 | |a DESIGN: Cohort analytical study, single center | ||
| 520 | |a SETTING: Units other than intensive care units | ||
| 520 | |a PATIENTS: Records of adults with mild to moderate hypoxemia due to coronavirus type 2 | ||
| 520 | |a INTERVENTIONS: None | ||
| 520 | |a MAIN VARIABLES OF INTEREST: Need for intubation or mortality | ||
| 520 | |a RESULTS: 159 patients were included in the study, with a ratio by support of 2:10 (H_CPAP:HFNO). The 46.5% were women, with no significant differences by sex according to support (p = 0.99, Fisher test). The APACHE II score, for HFNO, had a median of 10.5, 3.5 units higher than H_CPAP (p < 0.01, Wilcoxon rank sum). The risk of intubation in HFNO was 42.1% and in H_CPAP 3.8%, with a significant risk reduction of 91% (95% CI: 36.9%-98.7%; p < 0.01). APACHE II does not modify or confound the support and intubation relationship (p > 0.2, binomial regression); however, it does confound the support and mortality relationship (p = 0.82, RR homogeneity test). Despite a 79.1% reduction in mortality risk with H_CPAP, this reduction was not statistically significant (p = 0.11, binomial regression) | ||
| 520 | |a CONCLUSIONS: The use of Helmet CPAP, when compared to HFNO, was an effective therapeutic ventilatory support strategy to reduce the risk of intubation in patients with mild to moderate hypoxemia caused by coronavirus type 2 in inpatient units other than intensive care. The limitations associated with the difference in size, age and severity between the arms could generate bias | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acute Respiratory Distress Syndrome (ARDS) | |
| 650 | 4 | |a CPAP | |
| 650 | 4 | |a Coronavirus | |
| 650 | 4 | |a Covid 19 | |
| 650 | 4 | |a Helmet | |
| 650 | 4 | |a PEEP | |
| 650 | 4 | |a Síndrome de distrés respiratorio agudo (SDRA) | |
| 700 | 1 | |a Orellana-Cáceres, Juan José |e verfasserin |4 aut | |
| 700 | 1 | |a Fernández, Vicente |e verfasserin |4 aut | |
| 700 | 1 | |a Poblete, Felipe |e verfasserin |4 aut | |
| 700 | 1 | |a Reyes, Priscila |e verfasserin |4 aut | |
| 700 | 1 | |a Rebolledo, Kevin |e verfasserin |4 aut | |
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