Nature-Inspired Gelatin-Based Adhesive Hydrogel : A Rapid andUser-Friendly Solution for Hemostatic Applications
This article is protected by copyright. All rights reserved..
Conventional hemostatic agents face challenges in achieving rapid hemostasis and effective tissue repair due to limited hemostatic scenarios, suboptimal efficacy, and inadequate adhesion to wet tissues. Drawing inspiration from nature-sourced materials, we designed a gelatin-based adhesive hydrogel (AOT), easily prepared and quick to form, driven by Schiff base and multiple hydrogen bonds for applications in arterial and liver bleeding models. AOT exhibited exceptional adhesion to wet tissues (48.67 ± 0.16 kPa) and displays superior hemostatic properties with reduced blood loss and hemostatic time compared to other hydrogels and conventional hemostatic materials. Moreover, AOT hydrogel exhibited good biocompatibility and biodegradability. In summary, this easily prepared adhesisve hydrogel has the potential to supplant traditional hemostatic agents, offering a novel approach to achieve swift sealing of hemostasis and facilitate wound healing and repair in broader application scenarios, owing to its unique advantages. This article is protected by copyright. All rights reserved.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
|---|---|
| Enthalten in: |
Advanced healthcare materials - (2024) vom: 27. März, Seite e2304444 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Wang, Haihua [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Arteries injury models |
|---|
| Anmerkungen: |
Date Revised 27.03.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1002/adhm.202304444 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM370276264 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM370276264 | ||
| 003 | DE-627 | ||
| 005 | 20240329001720.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240329s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/adhm.202304444 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1353.xml |
| 035 | |a (DE-627)NLM370276264 | ||
| 035 | |a (NLM)38538084 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Wang, Haihua |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Nature-Inspired Gelatin-Based Adhesive Hydrogel |b A Rapid andUser-Friendly Solution for Hemostatic Applications |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 27.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a This article is protected by copyright. All rights reserved. | ||
| 520 | |a Conventional hemostatic agents face challenges in achieving rapid hemostasis and effective tissue repair due to limited hemostatic scenarios, suboptimal efficacy, and inadequate adhesion to wet tissues. Drawing inspiration from nature-sourced materials, we designed a gelatin-based adhesive hydrogel (AOT), easily prepared and quick to form, driven by Schiff base and multiple hydrogen bonds for applications in arterial and liver bleeding models. AOT exhibited exceptional adhesion to wet tissues (48.67 ± 0.16 kPa) and displays superior hemostatic properties with reduced blood loss and hemostatic time compared to other hydrogels and conventional hemostatic materials. Moreover, AOT hydrogel exhibited good biocompatibility and biodegradability. In summary, this easily prepared adhesisve hydrogel has the potential to supplant traditional hemostatic agents, offering a novel approach to achieve swift sealing of hemostasis and facilitate wound healing and repair in broader application scenarios, owing to its unique advantages. This article is protected by copyright. All rights reserved | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Schiff base bond | |
| 650 | 4 | |a arteries injury models | |
| 650 | 4 | |a gelatin‐based adhesive hydrogel | |
| 650 | 4 | |a hydrogen bond | |
| 650 | 4 | |a in vivo hemostasis | |
| 650 | 4 | |a liver injury models | |
| 650 | 4 | |a wound healing repair | |
| 700 | 1 | |a Wang, Mengxi |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Jingheng |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Shilei |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Yanan |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yushan |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Ke |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Ruyue |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Yuhang |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Meng |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Meng, Leixin |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Advanced healthcare materials |d 2012 |g (2024) vom: 27. März, Seite e2304444 |w (DE-627)NLM218710070 |x 2192-2659 |7 nnns |
| 773 | 1 | 8 | |g year:2024 |g day:27 |g month:03 |g pages:e2304444 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1002/adhm.202304444 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2024 |b 27 |c 03 |h e2304444 | ||