Combined Neutrophil-to-Lymphocyte Ratio Score Is Associated With Chemotherapeutic Response and Predicts Prognosis in Patients With Advanced Pancreatic Cancer
Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved..
BACKGROUND/AIM: Neutrophil-to-lymphocyte ratio (NLR) is a prognostic indicator for several malignancies, including pancreatic cancer. We developed a novel combined NLR score (cNLRS) based on baseline NLR and change in NLR after chemotherapy (ΔNLR), and examined its prognostic value and role in chemotherapeutic response in patients with advanced pancreatic cancer.
PATIENTS AND METHODS: This study retrospectively assessed 210 advanced pancreatic cancer patients receiving chemotherapy between 2010 and 2021. The cNLRS was developed and its association with chemotherapeutic response and prognosis was investigated.
RESULTS: The cNLRS consisted of baseline NLR ≥2.5 and ΔNLR ≥0, both of which were remained as independent poor predictors of prognosis adjusting for other traditional clinicopathological features. A high cNLRS served as an independent prognostic factor of reduced overall survival. Of note, the cNLRS was significantly associated with disease control rate and treatment duration not only in 1st line treatment but also in 2nd line treatment.
CONCLUSION: The cNLRS established as a useful prognostic biomarker might be associated with chemotherapeutic response and could predict survival in advanced patients with pancreatic ductal adenocarcinoma treated with chemotherapy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:44 |
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| Enthalten in: |
Anticancer research - 44(2024), 4 vom: 27. März, Seite 1575-1582 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Okabe, Hirohisa [VerfasserIn] |
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| Links: |
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| Themen: |
Advanced pancreatic cancer |
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| Anmerkungen: |
Date Completed 29.03.2024 Date Revised 29.03.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.21873/anticanres.16955 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370275055 |
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| 500 | |a Date Revised 29.03.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. | ||
| 520 | |a BACKGROUND/AIM: Neutrophil-to-lymphocyte ratio (NLR) is a prognostic indicator for several malignancies, including pancreatic cancer. We developed a novel combined NLR score (cNLRS) based on baseline NLR and change in NLR after chemotherapy (ΔNLR), and examined its prognostic value and role in chemotherapeutic response in patients with advanced pancreatic cancer | ||
| 520 | |a PATIENTS AND METHODS: This study retrospectively assessed 210 advanced pancreatic cancer patients receiving chemotherapy between 2010 and 2021. The cNLRS was developed and its association with chemotherapeutic response and prognosis was investigated | ||
| 520 | |a RESULTS: The cNLRS consisted of baseline NLR ≥2.5 and ΔNLR ≥0, both of which were remained as independent poor predictors of prognosis adjusting for other traditional clinicopathological features. A high cNLRS served as an independent prognostic factor of reduced overall survival. Of note, the cNLRS was significantly associated with disease control rate and treatment duration not only in 1st line treatment but also in 2nd line treatment | ||
| 520 | |a CONCLUSION: The cNLRS established as a useful prognostic biomarker might be associated with chemotherapeutic response and could predict survival in advanced patients with pancreatic ductal adenocarcinoma treated with chemotherapy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Neutrophil-lymphocyte ratio | |
| 650 | 4 | |a advanced pancreatic cancer | |
| 650 | 4 | |a chemotherapy | |
| 650 | 4 | |a combined NLR score | |
| 650 | 4 | |a disease control rate | |
| 650 | 4 | |a prognosis | |
| 700 | 1 | |a Masuda, Toshiro |e verfasserin |4 aut | |
| 700 | 1 | |a Tomita, Masahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Ono, Asuka |e verfasserin |4 aut | |
| 700 | 1 | |a Ogawa, Daisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Kuroda, Daisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Kuroki, Hideyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Hirota, Masahiko |e verfasserin |4 aut | |
| 700 | 1 | |a Hibi, Taizo |e verfasserin |4 aut | |
| 700 | 1 | |a Baba, Hideo |e verfasserin |4 aut | |
| 700 | 1 | |a Sugita, Hiroki |e verfasserin |4 aut | |
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