Oral Microbiota and Porphyromonas gingivalis Kgp Genotypes Altered in Parkinson's Disease with Mild Cognitive Impairment
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature..
Cognitive impairment (CI) is a common complication of the non-motor symptoms in Parkinson's disease (PD), including PD with mild cognitive impairment (PD-MCI) and PD dementia. Recent studies reported the oral dysbiosis in PD and CI, respectively. Porphyromonas gingivalis (P. gingivalis), a pathogen of oral dysbiosis, plays an important role in PD, whose lysine-gingipain (Kgp) could lead to AD-type pathologies. No previous study investigated the composition of oral microbiota and role of P. gingivalis in PD-MCI. This study aimed to investigate the differences of oral microbiota composition, P. gingivalis copy number, and Kgp genotypes among PD-MCI, PD with normal cognition (PD-NC) and periodontal status-matched control (PC) groups. The oral bacteria composition, the copy number of P. gingivalis, and the Kgp genotypes in gingival crevicular fluid from PD-MCI, PD-NC, and PC were analyzed using 16S ribosomal RNA sequencing, quantitative real-time PCR, and MseI restriction. We found that the structures of oral microbiota in PD-MCI group were significantly different compared to that in PD-NC and PC group. The relative abundances of Prevotella, Lactobacillus, Megasphaera, Atopobium, and Howardella were negatively correlated with cognitive score. Moreover, there was a significant difference of Kgp genotypes among the three groups. The predominant Kgp genotypes of P. gingivalis in the PD-MCI group were primarily Kgp II, whereas in the PD-NC group, it was mainly Kgp I. The Kgp II correlated with lower MMSE and MoCA scores, which suggested that Kgp genotypes II is related to cognitive impairment in PD.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2024 |
---|---|
Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
---|---|
Enthalten in: |
Molecular neurobiology - (2024) vom: 27. März |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Li, Dongcheng [VerfasserIn] |
---|
Links: |
---|
Themen: |
Cognition impairment |
---|
Anmerkungen: |
Date Revised 27.03.2024 published: Print-Electronic Citation Status Publisher |
---|
doi: |
10.1007/s12035-024-04119-2 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM370261593 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM370261593 | ||
003 | DE-627 | ||
005 | 20240329001529.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240329s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s12035-024-04119-2 |2 doi | |
028 | 5 | 2 | |a pubmed24n1353.xml |
035 | |a (DE-627)NLM370261593 | ||
035 | |a (NLM)38536604 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Li, Dongcheng |e verfasserin |4 aut | |
245 | 1 | 0 | |a Oral Microbiota and Porphyromonas gingivalis Kgp Genotypes Altered in Parkinson's Disease with Mild Cognitive Impairment |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Revised 27.03.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status Publisher | ||
520 | |a © 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. | ||
520 | |a Cognitive impairment (CI) is a common complication of the non-motor symptoms in Parkinson's disease (PD), including PD with mild cognitive impairment (PD-MCI) and PD dementia. Recent studies reported the oral dysbiosis in PD and CI, respectively. Porphyromonas gingivalis (P. gingivalis), a pathogen of oral dysbiosis, plays an important role in PD, whose lysine-gingipain (Kgp) could lead to AD-type pathologies. No previous study investigated the composition of oral microbiota and role of P. gingivalis in PD-MCI. This study aimed to investigate the differences of oral microbiota composition, P. gingivalis copy number, and Kgp genotypes among PD-MCI, PD with normal cognition (PD-NC) and periodontal status-matched control (PC) groups. The oral bacteria composition, the copy number of P. gingivalis, and the Kgp genotypes in gingival crevicular fluid from PD-MCI, PD-NC, and PC were analyzed using 16S ribosomal RNA sequencing, quantitative real-time PCR, and MseI restriction. We found that the structures of oral microbiota in PD-MCI group were significantly different compared to that in PD-NC and PC group. The relative abundances of Prevotella, Lactobacillus, Megasphaera, Atopobium, and Howardella were negatively correlated with cognitive score. Moreover, there was a significant difference of Kgp genotypes among the three groups. The predominant Kgp genotypes of P. gingivalis in the PD-MCI group were primarily Kgp II, whereas in the PD-NC group, it was mainly Kgp I. The Kgp II correlated with lower MMSE and MoCA scores, which suggested that Kgp genotypes II is related to cognitive impairment in PD | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Porphyromonas gingivalis | |
650 | 4 | |a Cognition impairment | |
650 | 4 | |a High throughput sequencing | |
650 | 4 | |a Lysine-gingipain genotypes | |
650 | 4 | |a Oral micro biome | |
650 | 4 | |a Parkinson’s disease | |
700 | 1 | |a Ren, Tengzhu |e verfasserin |4 aut | |
700 | 1 | |a Li, Hao |e verfasserin |4 aut | |
700 | 1 | |a Huang, Mingdi |e verfasserin |4 aut | |
700 | 1 | |a Chen, Jiaxin |e verfasserin |4 aut | |
700 | 1 | |a He, Qishan |e verfasserin |4 aut | |
700 | 1 | |a Lv, Wei |e verfasserin |4 aut | |
700 | 1 | |a Liu, Hailing |e verfasserin |4 aut | |
700 | 1 | |a Xu, Renshi |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Xiong |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Molecular neurobiology |d 1990 |g (2024) vom: 27. März |w (DE-627)NLM012626961 |x 1559-1182 |7 nnns |
773 | 1 | 8 | |g year:2024 |g day:27 |g month:03 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/s12035-024-04119-2 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |j 2024 |b 27 |c 03 |