Peripheral blood syndecan-1 levels after mechanical thrombectomy can predict the clinical prognosis of patients with acute ischemic stroke
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature..
BACKGROUND: Previously, we revealed noticeable dynamic fluctuations in syndecan-1 levels in the peripheral blood of post-stroke patients. We further investigated the clinical prognostic value of syndecan-1 as a biomarker of glycoprotein damage in patients with acute ischaemic stroke (AIS).
METHODS: We examined 105 patients with acute large vessel occlusion in the anterior circulation, all of whom underwent mechanical thrombectomy (MT). Peripheral blood syndecan-1 levels were measured 1 day after MT, and patients were categorised into favourable and unfavourable prognostic groups based on the 90-day modified Rankin Scale (mRS) score. Additionally, we compared the clinical outcomes between groups with high and low syndecan-1 concentrations.
RESULTS: The findings revealed a significantly lower syndecan-1 level in the group with an unfavourable prognosis compared to those with a favourable prognosis (p < 0.01). In the multivariable logistic regression analysis, lower syndecan-1 levels were identified as a predictor of unfavourable prognosis (odds ratio (OR) = 0.965, p = 0.001). Patients displaying low syndecan-1 expression in the peripheral blood (< 29.51 ng/mL) experienced a > twofold increase in the rates of unfavourable prognosis and mortality.
CONCLUSIONS: Our study demonstrates that syndecan-1, as an emerging, easily detectable stroke biomarker, can predict the clinical outcomes of patients with AIS. After MT, low levels of syndecan-1 in the peripheral blood on the first day emerged as an independent risk factor for an unfavourable prognosis, suggesting that lower syndecan-1 levels might signify worse clinical presentation and outcomes in stroke patients undergoing this procedure.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:166 |
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| Enthalten in: |
Acta neurochirurgica - 166(2024), 1 vom: 27. März, Seite 153 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Xu, Bin [VerfasserIn] |
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| Links: |
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| Themen: |
Acute ischemic stroke |
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| Anmerkungen: |
Date Completed 29.03.2024 Date Revised 09.04.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00701-024-06004-2 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM37026035X |
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| 245 | 1 | 0 | |a Peripheral blood syndecan-1 levels after mechanical thrombectomy can predict the clinical prognosis of patients with acute ischemic stroke |
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| 520 | |a © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature. | ||
| 520 | |a BACKGROUND: Previously, we revealed noticeable dynamic fluctuations in syndecan-1 levels in the peripheral blood of post-stroke patients. We further investigated the clinical prognostic value of syndecan-1 as a biomarker of glycoprotein damage in patients with acute ischaemic stroke (AIS) | ||
| 520 | |a METHODS: We examined 105 patients with acute large vessel occlusion in the anterior circulation, all of whom underwent mechanical thrombectomy (MT). Peripheral blood syndecan-1 levels were measured 1 day after MT, and patients were categorised into favourable and unfavourable prognostic groups based on the 90-day modified Rankin Scale (mRS) score. Additionally, we compared the clinical outcomes between groups with high and low syndecan-1 concentrations | ||
| 520 | |a RESULTS: The findings revealed a significantly lower syndecan-1 level in the group with an unfavourable prognosis compared to those with a favourable prognosis (p < 0.01). In the multivariable logistic regression analysis, lower syndecan-1 levels were identified as a predictor of unfavourable prognosis (odds ratio (OR) = 0.965, p = 0.001). Patients displaying low syndecan-1 expression in the peripheral blood (< 29.51 ng/mL) experienced a > twofold increase in the rates of unfavourable prognosis and mortality | ||
| 520 | |a CONCLUSIONS: Our study demonstrates that syndecan-1, as an emerging, easily detectable stroke biomarker, can predict the clinical outcomes of patients with AIS. After MT, low levels of syndecan-1 in the peripheral blood on the first day emerged as an independent risk factor for an unfavourable prognosis, suggesting that lower syndecan-1 levels might signify worse clinical presentation and outcomes in stroke patients undergoing this procedure | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acute ischemic stroke | |
| 650 | 4 | |a Mechanical thrombectomy | |
| 650 | 4 | |a Prognosis | |
| 650 | 4 | |a Syndecan-1 | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a Syndecan-1 |2 NLM | |
| 700 | 1 | |a Yin, Tengkun |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Tanggui |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Zhongchen |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Zhiyuan |e verfasserin |4 aut | |
| 700 | 1 | |a Lv, Hang |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Chonghui |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Jiyue |e verfasserin |4 aut | |
| 700 | 1 | |a Hao, Jiheng |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Liyong |e verfasserin |4 aut | |
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