A radical 1,4-aryl migration enables nickel-catalysed remote cross-electrophile coupling of β-bromo amino acid esters with vinyl triflates
A radical 1,4-aryl migration enabling a cross-electrophile coupling reaction toward remote transalkylation of N-benzyl alanine has been developed. In this strategy, with the occurrence of a radical-mediated Turce-Smiles rearrangement, key α-aminoalkyl radicals are generated. The as-formed α-aminoalkyl radical serves as a robust coupling partner for cross-electrophilic coupling with vinyl triflates, affording a series of olefin-tethered amino acid motifs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:60 |
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| Enthalten in: |
Chemical communications (Cambridge, England) - 60(2024), 32 vom: 16. Apr., Seite 4306-4309 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Yin-Ling [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 16.04.2024 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/d4cc00627e |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM370231090 |
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| 100 | 1 | |a Liu, Yin-Ling |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A radical 1,4-aryl migration enables nickel-catalysed remote cross-electrophile coupling of β-bromo amino acid esters with vinyl triflates |
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| 520 | |a A radical 1,4-aryl migration enabling a cross-electrophile coupling reaction toward remote transalkylation of N-benzyl alanine has been developed. In this strategy, with the occurrence of a radical-mediated Turce-Smiles rearrangement, key α-aminoalkyl radicals are generated. The as-formed α-aminoalkyl radical serves as a robust coupling partner for cross-electrophilic coupling with vinyl triflates, affording a series of olefin-tethered amino acid motifs | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Liu, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xin-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a He, Peng |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yu-Xuan |e verfasserin |4 aut | |
| 700 | 1 | |a Xiang, Mei |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Shi |e verfasserin |4 aut | |
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