Heterocycle compounds synthesized by amide ligand-promoted copper salt catalyzed construction of C-O(S) bonds
This journal is © The Royal Society of Chemistry..
We introduce a mild method for the ligand-promoted copper-catalyzed coupling of 2-halophenol to construct DBDO using cost-effective copper salts, ligands, and alkaline reagents. This method cleverly makes 2-bromophenol complete the Ullman reaction twice, achieves efficient C-O(S) bond coupling and intermolecular cyclization, and yields high amounts of oxygen(sulfur)-containing six-membered ring products. Less reactive 2-chlorophenol was also applied in this catalytic system. The application range of the copper-amide catalytic system was further expanded. Moreover, the success of a gram-scale reaction demonstrated that this operationally simple process is scalable.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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Enthalten in: |
RSC advances - 14(2024), 14 vom: 20. März, Seite 10034-10038 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Yin, Ruiting [VerfasserIn] |
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Date Revised 28.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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doi: |
10.1039/d4ra00701h |
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funding: |
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PPN (Katalog-ID): |
NLM370226488 |
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520 | |a We introduce a mild method for the ligand-promoted copper-catalyzed coupling of 2-halophenol to construct DBDO using cost-effective copper salts, ligands, and alkaline reagents. This method cleverly makes 2-bromophenol complete the Ullman reaction twice, achieves efficient C-O(S) bond coupling and intermolecular cyclization, and yields high amounts of oxygen(sulfur)-containing six-membered ring products. Less reactive 2-chlorophenol was also applied in this catalytic system. The application range of the copper-amide catalytic system was further expanded. Moreover, the success of a gram-scale reaction demonstrated that this operationally simple process is scalable | ||
650 | 4 | |a Journal Article | |
700 | 1 | |a Liu, Hailong |e verfasserin |4 aut | |
700 | 1 | |a Yang, Xue |e verfasserin |4 aut | |
700 | 1 | |a Zhou, Xiaoyu |e verfasserin |4 aut | |
700 | 1 | |a Chen, Xia |e verfasserin |4 aut | |
700 | 1 | |a Li, Shenmin |e verfasserin |4 aut | |
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