Combined frequency domain near-infrared spectroscopy and diffuse correlation spectroscopy system for comprehensive metabolic monitoring of inspiratory muscles during loading
© 2024 The Authors..
Significance: Mechanical ventilation (MV) is a cornerstone technology in the intensive care unit as it assists with the delivery of oxygen in critically ill patients. The process of weaning patients from MV can be long and arduous and can lead to serious complications for many patients. Despite the known importance of inspiratory muscle function in the success of weaning, current clinical standards do not include direct monitoring of these muscles.
Aim: The goal of this project was to develop and validate a combined frequency domain near-infrared spectroscopy (FD-NIRS) and diffuse correlation spectroscopy (DCS) system for the noninvasive characterization of inspiratory muscle response to a load.
Approach: The system was fabricated by combining a custom digital FD-NIRS and DCS system. It was validated via liquid phantom titrations and a healthy volunteer study. The sternocleidomastoid (SCM), an accessory muscle of inspiration, was monitored during a short loading period in fourteen young, healthy volunteers. Volunteers performed two different respiratory exercises, a moderate load and a high load, which consisted of a one-minute baseline, a one-minute load, and a six-minute recovery period.
Results: The system has low crosstalk between absorption, reduced scattering, and flow when tested in a set of liquid titrations. Faster dynamics were observed for changes in blood flow index (BFi), and metabolic rate of oxygen (MRO2) compared with hemoglobin + myoglobin (Hb+Mb) based parameters after the onset of loads in males. Additionally, larger percent changes in BFi, and MRO2 were observed compared with Hb+Mb parameters in both males and females. There were also sex differences in baseline values of oxygenated Hb+Mb, total Hb+Mb, and tissue saturation.
Conclusions: The dynamic characteristics of Hb+Mb concentration and blood flow were distinct during loading of the SCM, suggesting that the combination of FD-NIRS and DCS may provide a more complete picture of inspiratory muscle dynamics.
| Errataetall: | |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Journal of biomedical optics - 29(2024), 3 vom: 27. März, Seite 035002 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gómez, Carlos A [VerfasserIn] |
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| Links: |
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| Themen: |
Diffuse correlation spectroscopy |
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| Anmerkungen: |
Date Completed 28.03.2024 Date Revised 08.04.2024 published: Print-Electronic UpdateOf: bioRxiv. 2023 Dec 01;:. - PMID 38076980 Citation Status MEDLINE |
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| doi: |
10.1117/1.JBO.29.3.035002 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370225104 |
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| 100 | 1 | |a Gómez, Carlos A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Combined frequency domain near-infrared spectroscopy and diffuse correlation spectroscopy system for comprehensive metabolic monitoring of inspiratory muscles during loading |
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| 500 | |a Date Revised 08.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a UpdateOf: bioRxiv. 2023 Dec 01;:. - PMID 38076980 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2024 The Authors. | ||
| 520 | |a Significance: Mechanical ventilation (MV) is a cornerstone technology in the intensive care unit as it assists with the delivery of oxygen in critically ill patients. The process of weaning patients from MV can be long and arduous and can lead to serious complications for many patients. Despite the known importance of inspiratory muscle function in the success of weaning, current clinical standards do not include direct monitoring of these muscles | ||
| 520 | |a Aim: The goal of this project was to develop and validate a combined frequency domain near-infrared spectroscopy (FD-NIRS) and diffuse correlation spectroscopy (DCS) system for the noninvasive characterization of inspiratory muscle response to a load | ||
| 520 | |a Approach: The system was fabricated by combining a custom digital FD-NIRS and DCS system. It was validated via liquid phantom titrations and a healthy volunteer study. The sternocleidomastoid (SCM), an accessory muscle of inspiration, was monitored during a short loading period in fourteen young, healthy volunteers. Volunteers performed two different respiratory exercises, a moderate load and a high load, which consisted of a one-minute baseline, a one-minute load, and a six-minute recovery period | ||
| 520 | |a Results: The system has low crosstalk between absorption, reduced scattering, and flow when tested in a set of liquid titrations. Faster dynamics were observed for changes in blood flow index (BFi), and metabolic rate of oxygen (MRO2) compared with hemoglobin + myoglobin (Hb+Mb) based parameters after the onset of loads in males. Additionally, larger percent changes in BFi, and MRO2 were observed compared with Hb+Mb parameters in both males and females. There were also sex differences in baseline values of oxygenated Hb+Mb, total Hb+Mb, and tissue saturation | ||
| 520 | |a Conclusions: The dynamic characteristics of Hb+Mb concentration and blood flow were distinct during loading of the SCM, suggesting that the combination of FD-NIRS and DCS may provide a more complete picture of inspiratory muscle dynamics | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a diffuse correlation spectroscopy | |
| 650 | 4 | |a diffuse optics | |
| 650 | 4 | |a mechanical ventilation | |
| 650 | 4 | |a near-infrared spectroscopy | |
| 650 | 4 | |a respiratory muscles | |
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| 650 | 7 | |a Hemoglobins |2 NLM | |
| 650 | 7 | |a Oxyhemoglobins |2 NLM | |
| 700 | 1 | |a Brochard, Laurent |e verfasserin |4 aut | |
| 700 | 1 | |a Goligher, Ewan C |e verfasserin |4 aut | |
| 700 | 1 | |a Rozenberg, Dmitry |e verfasserin |4 aut | |
| 700 | 1 | |a Reid, W Darlene |e verfasserin |4 aut | |
| 700 | 1 | |a Roblyer, Darren |e verfasserin |4 aut | |
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