Pre-morbid sleep disturbance and its association with stroke severity : results from the international INTERSTROKE study
© 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology..
BACKGROUND AND PURPOSE: Whilst sleep disturbances are associated with stroke, their association with stroke severity is less certain. In the INTERSTROKE study, the association of pre-morbid sleep disturbance with stroke severity and functional outcome following stroke was evaluated.
METHODS: INTERSTROKE is an international case-control study of first acute stroke. This analysis included cases who completed a standardized questionnaire concerning nine symptoms of sleep disturbance (sleep onset latency, duration, quality, nocturnal awakening, napping duration, whether a nap was planned, snoring, snorting and breathing cessation) in the month prior to stroke (n = 2361). Two indices were derived representing sleep disturbance (range 0-9) and obstructive sleep apnoea (range 0-3) symptoms. Logistic regression was used to estimate the magnitude of association between symptoms and stroke severity defined by the modified Rankin Score.
RESULTS: The mean age of participants was 62.9 years, and 42% were female. On multivariable analysis, there was a graded association between increasing number of sleep disturbance symptoms and initially severe stroke (2-3, odds ratio [OR] 1.44, 95% confidence interval [CI] 1.07-1.94; 4-5, OR 1.66, 95% CI 1.23-2.25; >5, OR 2.58, 95% CI 1.83-3.66). Having >5 sleep disturbance symptoms was associated with significantly increased odds of functional deterioration at 1 month (OR 1.54, 95% CI 1.01-2.34). A higher obstructive sleep apnoea score was also associated with significantly increased odds of initially severe stroke (2-3, OR 1.48; 95% CI 1.20-1.83) but not functional deterioration at 1 month (OR 1.19, 95% CI 0.93-1.52).
CONCLUSIONS: Sleep disturbance symptoms were common and associated with an increased odds of severe stroke and functional deterioration. Interventions to modify sleep disturbance may help prevent disabling stroke/improve functional outcomes and should be the subject of future research.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
European journal of neurology - (2024) vom: 26. März, Seite e16193 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mc Carthy, Christine E [VerfasserIn] |
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| Links: |
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| Themen: |
Disability evaluation |
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| Anmerkungen: |
Date Revised 27.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.1111/ene.16193 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370218574 |
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| 100 | 1 | |a Mc Carthy, Christine E |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Pre-morbid sleep disturbance and its association with stroke severity |b results from the international INTERSTROKE study |
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| 500 | |a Citation Status Publisher | ||
| 520 | |a © 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. | ||
| 520 | |a BACKGROUND AND PURPOSE: Whilst sleep disturbances are associated with stroke, their association with stroke severity is less certain. In the INTERSTROKE study, the association of pre-morbid sleep disturbance with stroke severity and functional outcome following stroke was evaluated | ||
| 520 | |a METHODS: INTERSTROKE is an international case-control study of first acute stroke. This analysis included cases who completed a standardized questionnaire concerning nine symptoms of sleep disturbance (sleep onset latency, duration, quality, nocturnal awakening, napping duration, whether a nap was planned, snoring, snorting and breathing cessation) in the month prior to stroke (n = 2361). Two indices were derived representing sleep disturbance (range 0-9) and obstructive sleep apnoea (range 0-3) symptoms. Logistic regression was used to estimate the magnitude of association between symptoms and stroke severity defined by the modified Rankin Score | ||
| 520 | |a RESULTS: The mean age of participants was 62.9 years, and 42% were female. On multivariable analysis, there was a graded association between increasing number of sleep disturbance symptoms and initially severe stroke (2-3, odds ratio [OR] 1.44, 95% confidence interval [CI] 1.07-1.94; 4-5, OR 1.66, 95% CI 1.23-2.25; >5, OR 2.58, 95% CI 1.83-3.66). Having >5 sleep disturbance symptoms was associated with significantly increased odds of functional deterioration at 1 month (OR 1.54, 95% CI 1.01-2.34). A higher obstructive sleep apnoea score was also associated with significantly increased odds of initially severe stroke (2-3, OR 1.48; 95% CI 1.20-1.83) but not functional deterioration at 1 month (OR 1.19, 95% CI 0.93-1.52) | ||
| 520 | |a CONCLUSIONS: Sleep disturbance symptoms were common and associated with an increased odds of severe stroke and functional deterioration. Interventions to modify sleep disturbance may help prevent disabling stroke/improve functional outcomes and should be the subject of future research | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a disability evaluation | |
| 650 | 4 | |a sleep | |
| 650 | 4 | |a sleep apnea, obstructive | |
| 650 | 4 | |a sleep initiation and maintenance disorders | |
| 650 | 4 | |a stroke | |
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| 700 | 1 | |a Judge, Conor |e verfasserin |4 aut | |
| 700 | 1 | |a Ferguson, John |e verfasserin |4 aut | |
| 700 | 1 | |a Hankey, Graeme J |e verfasserin |4 aut | |
| 700 | 1 | |a Gharan, Shahram Oveis |e verfasserin |4 aut | |
| 700 | 1 | |a Damasceno, Albertino |e verfasserin |4 aut | |
| 700 | 1 | |a Iversen, Helle Klingenberg |e verfasserin |4 aut | |
| 700 | 1 | |a Rosengren, Annika |e verfasserin |4 aut | |
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| 700 | 1 | |a Wang, Xingyu |e verfasserin |4 aut | |
| 700 | 1 | |a Rangarajan, Sumathy |e verfasserin |4 aut | |
| 700 | 1 | |a O'Donnell, Martin J |e verfasserin |4 aut | |
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