Impact of the Kidney Allocation Revision on Access to Kidney Transplantation and Outcomes in the United States
BACKGROUND: The 2014 Kidney Allocation System (KAS) revision aimed to enhance equity in organ allocation and improve patient outcomes. This study assesses the impacts of the KAS revision on renal transplantation demographics and outcomes in the United States.
METHODS: We conducted a retrospective study utilizing the Organ Procurement and Transplantation Network/Scientific Registry of Transplant Recipients (OPTN/SRTR) database from 1998 to 2022. We compared recipient and donor characteristics, and outcomes (graft failure and recipient survival) pre- and post-KAS revision.
RESULTS: Post-KAS, recipients were significantly older (53 vs 48, P < .001) with an increase in Medicaid beneficiaries (7.3% vs 5.5%, P < .001). Despite increased graft survival, HR = .91 (95% CI 0.80-.92, P < .001), overall recipient survival decreased, HR = 1.06 (95% CI 1.04-1.09, P < .001). KAS revision led to greater racial diversity among recipients and donors, enhancing equity in organ allocation. However, disparities persist in graft failure rates and recipient survival across racial groups.
DISCUSSION: The 2014 Kidney Allocation System revision has led to important changes in the renal transplantation landscape. While progress has been made towards increasing racial equity in organ allocation, further refinements are needed to address ongoing disparities. Recognizing the changing patient profiles and socio-economic factors will be crucial in shaping future policy modifications.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
|---|---|
| Enthalten in: |
The American surgeon - (2024) vom: 26. März, Seite 31348241241628 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Akinyemi, Oluwasegun A [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Health disparities |
|---|
| Anmerkungen: |
Date Revised 26.03.2024 published: Print-Electronic Citation Status Publisher |
|---|
| doi: |
10.1177/00031348241241628 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM370213580 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM370213580 | ||
| 003 | DE-627 | ||
| 005 | 20240328000801.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240328s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/00031348241241628 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1351.xml |
| 035 | |a (DE-627)NLM370213580 | ||
| 035 | |a (NLM)38531806 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Akinyemi, Oluwasegun A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Impact of the Kidney Allocation Revision on Access to Kidney Transplantation and Outcomes in the United States |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 26.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a BACKGROUND: The 2014 Kidney Allocation System (KAS) revision aimed to enhance equity in organ allocation and improve patient outcomes. This study assesses the impacts of the KAS revision on renal transplantation demographics and outcomes in the United States | ||
| 520 | |a METHODS: We conducted a retrospective study utilizing the Organ Procurement and Transplantation Network/Scientific Registry of Transplant Recipients (OPTN/SRTR) database from 1998 to 2022. We compared recipient and donor characteristics, and outcomes (graft failure and recipient survival) pre- and post-KAS revision | ||
| 520 | |a RESULTS: Post-KAS, recipients were significantly older (53 vs 48, P < .001) with an increase in Medicaid beneficiaries (7.3% vs 5.5%, P < .001). Despite increased graft survival, HR = .91 (95% CI 0.80-.92, P < .001), overall recipient survival decreased, HR = 1.06 (95% CI 1.04-1.09, P < .001). KAS revision led to greater racial diversity among recipients and donors, enhancing equity in organ allocation. However, disparities persist in graft failure rates and recipient survival across racial groups | ||
| 520 | |a DISCUSSION: The 2014 Kidney Allocation System revision has led to important changes in the renal transplantation landscape. While progress has been made towards increasing racial equity in organ allocation, further refinements are needed to address ongoing disparities. Recognizing the changing patient profiles and socio-economic factors will be crucial in shaping future policy modifications | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Kidney Allocation System | |
| 650 | 4 | |a health disparities | |
| 650 | 4 | |a health equity | |
| 650 | 4 | |a kidney transplant | |
| 650 | 4 | |a organ allocation | |
| 650 | 4 | |a patient outcomes | |
| 650 | 4 | |a socioeconomic status | |
| 650 | 4 | |a transplant surgery | |
| 700 | 1 | |a Weldeslase, Terhas A |e verfasserin |4 aut | |
| 700 | 1 | |a Odusanya, Eunice A |e verfasserin |4 aut | |
| 700 | 1 | |a Hughes, Kakra |e verfasserin |4 aut | |
| 700 | 1 | |a Cornwell, Edward E |e verfasserin |4 aut | |
| 700 | 1 | |a Callender, Clive O |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The American surgeon |d 1951 |g (2024) vom: 26. März, Seite 31348241241628 |w (DE-627)NLM000046418 |x 1555-9823 |7 nnns |
| 773 | 1 | 8 | |g year:2024 |g day:26 |g month:03 |g pages:31348241241628 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1177/00031348241241628 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |j 2024 |b 26 |c 03 |h 31348241241628 | ||