Myxomatous mitral valve disease and associated pulmonary hypertension might increase serum angiopoietin-2 in dogs
OBJECTIVE: To evaluate the relationships between the severity of myxomatous mitral valve disease (MMVD) and pulmonary hypertension (PH) and serum angiopoietin (Ang)-1 and Ang-2 concentrations in dogs with MMVD.
ANIMALS: 74 dogs (control, n = 12; MMVD, n = 62) were included.
METHODS: Serum Ang-1 and Ang-2 concentrations were estimated using the canine-specific ELISA kit. The concentrations were compared between dogs with MMVD and healthy dogs, and they were analyzed according to the severity of MMVD and PH.
RESULTS: The median serum Ang-1 concentration did not differ among the study groups. The median serum Ang-2 concentration was higher in dogs with stage B2 MMVD (P = .041) and acute congestive heart failure (P = .002) than in control dogs. In addition, the median serum Ang-2 concentration was higher in MMVD dogs with PH than in those without PH (P = .031). Serum Ang-2 concentration was correlated with vertebral heart score (rs = 0.36, P = .004) and vertebral left atrial score (r = 0.50, P < .001) in dogs with MMVD, and correlated with vertebral heart score (r = 0.63, P = .01), maximum E wave amplitude of the diastolic transmitral flow (rs = 0.61, P = .018), ejection fraction (rs = -0.77, P < .001) and fractional shortening (rs = -0.56, P = .032) in dogs with acute congestive heart failure.
CLINICAL RELEVANCE: Circulating Ang-2 levels increase in dogs with the severity of MMVD and the presence of PH.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - year:2024 |
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| Enthalten in: |
American journal of veterinary research - (2024) vom: 30. März, Seite 1-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yu, Hogeun [VerfasserIn] |
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| Links: |
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| Themen: |
Angiopoietin |
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| Anmerkungen: |
Date Revised 26.03.2024 published: Print-Electronic Citation Status Publisher |
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| doi: |
10.2460/ajvr.23.12.0289 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM370207106 |
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| 245 | 1 | 0 | |a Myxomatous mitral valve disease and associated pulmonary hypertension might increase serum angiopoietin-2 in dogs |
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| 500 | |a Date Revised 26.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status Publisher | ||
| 520 | |a OBJECTIVE: To evaluate the relationships between the severity of myxomatous mitral valve disease (MMVD) and pulmonary hypertension (PH) and serum angiopoietin (Ang)-1 and Ang-2 concentrations in dogs with MMVD | ||
| 520 | |a ANIMALS: 74 dogs (control, n = 12; MMVD, n = 62) were included | ||
| 520 | |a METHODS: Serum Ang-1 and Ang-2 concentrations were estimated using the canine-specific ELISA kit. The concentrations were compared between dogs with MMVD and healthy dogs, and they were analyzed according to the severity of MMVD and PH | ||
| 520 | |a RESULTS: The median serum Ang-1 concentration did not differ among the study groups. The median serum Ang-2 concentration was higher in dogs with stage B2 MMVD (P = .041) and acute congestive heart failure (P = .002) than in control dogs. In addition, the median serum Ang-2 concentration was higher in MMVD dogs with PH than in those without PH (P = .031). Serum Ang-2 concentration was correlated with vertebral heart score (rs = 0.36, P = .004) and vertebral left atrial score (r = 0.50, P < .001) in dogs with MMVD, and correlated with vertebral heart score (r = 0.63, P = .01), maximum E wave amplitude of the diastolic transmitral flow (rs = 0.61, P = .018), ejection fraction (rs = -0.77, P < .001) and fractional shortening (rs = -0.56, P = .032) in dogs with acute congestive heart failure | ||
| 520 | |a CLINICAL RELEVANCE: Circulating Ang-2 levels increase in dogs with the severity of MMVD and the presence of PH | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a angiopoietin | |
| 650 | 4 | |a biomarker | |
| 650 | 4 | |a canine | |
| 650 | 4 | |a cardiac disease | |
| 650 | 4 | |a pulmonary hypertension | |
| 700 | 1 | |a Lee, Dohee |e verfasserin |4 aut | |
| 700 | 1 | |a Chae, Yeon |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Minseok |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Yelim |e verfasserin |4 aut | |
| 700 | 1 | |a Yun, Taesik |e verfasserin |4 aut | |
| 700 | 1 | |a Kang, Byeong-Teck |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Mhan-Pyo |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Hakhyun |e verfasserin |4 aut | |
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