Identification of macaque dendritic cell precursors in blood and tissue reveals their dysregulation in early SIV infection
Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved..
Distinct dendritic cell (DC) subsets play important roles in shaping immune responses. Circulating DC precursors (pre-DCs) are more susceptible to HIV infection in vitro, which may explain the inefficiency of immune responses against HIV. However, the interplay between HIV and pre-DC is not defined in vivo. We identify human pre-DC equivalents in the cynomolgus macaque and then analyze their dynamics during simian immunodeficiency virus (SIV) infection to illustrate a sharp decrease of blood pre-DCs in early SIV infection and accumulation in lymph nodes (LNs), where they neglect to upregulate CD83/CD86 or MHC-II. Additionally, SIV infection attenuates the capacity of stimulated LN pre-DCs to produce IL-12p40. Analysis of HIV cohorts provides correlation between costimulatory molecule expression on pre-DCs and T cell activation in spontaneous HIV controllers. These findings pinpoint certain dynamics and functional changes of pre-DCs during SIV infection, providing a deeper understanding of immune dysregulation mechanisms elicited in people living with HIV.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
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| Enthalten in: |
Cell reports - 43(2024), 4 vom: 23. Apr., Seite 113994 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gardet, Margaux [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 26.04.2024 Date Revised 27.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.celrep.2024.113994 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Distinct dendritic cell (DC) subsets play important roles in shaping immune responses. Circulating DC precursors (pre-DCs) are more susceptible to HIV infection in vitro, which may explain the inefficiency of immune responses against HIV. However, the interplay between HIV and pre-DC is not defined in vivo. We identify human pre-DC equivalents in the cynomolgus macaque and then analyze their dynamics during simian immunodeficiency virus (SIV) infection to illustrate a sharp decrease of blood pre-DCs in early SIV infection and accumulation in lymph nodes (LNs), where they neglect to upregulate CD83/CD86 or MHC-II. Additionally, SIV infection attenuates the capacity of stimulated LN pre-DCs to produce IL-12p40. Analysis of HIV cohorts provides correlation between costimulatory molecule expression on pre-DCs and T cell activation in spontaneous HIV controllers. These findings pinpoint certain dynamics and functional changes of pre-DCs during SIV infection, providing a deeper understanding of immune dysregulation mechanisms elicited in people living with HIV | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a CP: Immunology | |
| 650 | 4 | |a HIV | |
| 650 | 4 | |a HIV controllers | |
| 650 | 4 | |a SIV | |
| 650 | 4 | |a anti-viral immune responses | |
| 650 | 4 | |a cDC | |
| 650 | 4 | |a cynomolgus macaques | |
| 650 | 4 | |a immune dysregulation | |
| 650 | 4 | |a lymph nodes | |
| 650 | 4 | |a pDC | |
| 650 | 4 | |a pre-DC | |
| 700 | 1 | |a Haigh, Oscar |e verfasserin |4 aut | |
| 700 | 1 | |a Meurisse, Florian |e verfasserin |4 aut | |
| 700 | 1 | |a Coindre, Sixtine |e verfasserin |4 aut | |
| 700 | 1 | |a Dimant, Nastasia |e verfasserin |4 aut | |
| 700 | 1 | |a Desjardins, Delphine |e verfasserin |4 aut | |
| 700 | 1 | |a Bourgeois, Christine |e verfasserin |4 aut | |
| 700 | 1 | |a Goujard, Cecile |e verfasserin |4 aut | |
| 700 | 1 | |a Vaslin, Bruno |e verfasserin |4 aut | |
| 700 | 1 | |a Relouzat, Francis |e verfasserin |4 aut | |
| 700 | 1 | |a Le Grand, Roger |e verfasserin |4 aut | |
| 700 | 1 | |a Lambotte, Olivier |e verfasserin |4 aut | |
| 700 | 1 | |a Favier, Benoit |e verfasserin |4 aut | |
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